Safety and efficacy of currently available fibrin tissue adhesives

Siedentop, Karl H.; Park, John J.; Shah, Ami N.; Bhattacharyya, Tapan K.; O'Grady, Kevin

doi:10.1053/ajot.2001.24817

Cited by 55 publications

(21 citation statements)

References 10 publications

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“…However no reports of any related infection after the use of fibrin glue in any ocular surgery has been reported, yet. Fibrin glue prepared from autologous plasma may be the safest way to prevent transmissions of infectious agents; nevertheless it is expensive and it requires at least 24 hours preparing (Siedontop et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Tissue Adhesives as an Alternative for Conjunctival Closure in Strabismus Surgeries

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Tissue Adhesives as an Alternative for Conjunctival Closure in Strabismus Surgeries

et al. 2011

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“…[14,15] In addition, use of fibrin glue is limited by the time required to obtain and prepare the product. [15,16] Therefore, the search for an effective and rapid hemostasis method for dealing with this type of bleeding is particularly important.…”

Section: Discussionmentioning

confidence: 99%

A new technique for management of intercavernous sinus bleeding with titanium clips in transsphenoidal surgery

et al. 2010

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“…18 Siedentop et al described that after the injection of 0.05 mL glue and the same follow-up terms, there was ''no evidence of tissue reaction''. 11 Romanos and Strub studied the influence of fibrin glue on the connective tissue matrix. Subcutaneous implantation of 1 mL of Tissucol Duo 1 for 4, 7, 14, 21, or 28 days did not reveal inflammatory reactions in the lamina propria.…”

Section: Discussionmentioning

confidence: 99%

“…As a consequence, alternative methods are developed, such as the use of tissue fibrin glue. 3,10,11 Fibrin glue is known for its haemostatic properties. 12 In theory, it can reduce the chance on postimplantation infections.…”

Section: Introductionmentioning

confidence: 99%

Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue

Hallers

Jansen

Marres

et al. 2006

J Biomedical Materials Res

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Polypropylene (PP) and titanium (Ti) meshes are well-known surgical implants that provoke a relative low foreign body reaction. Firm stabilization of the implant is important to prevent migration and subsequent failure of the operation. Fibrin tissue glues are commercially available adhesives and are widely accepted and applied in the medical field for hemorrhage, surgical bleeding, support of wound healing, wound and tissue gluing, sealing, and closure but also as antiadhesive agent in certain applications. The objective of this study was to evaluate the additional histological effect of fibrin glue application combined with two different types of meshes. Six pieces of mesh of each were subcutaneously implanted for 3, 6, and 12 weeks, with and without fibrin glue. After excision, processing, and staining, light microscopic analysis was performed on the sections, using subjective histological description and histomorphometry. Capsule quality, capsule thickness, interstitial quality, and total score were evaluated. To compare the samples with glue and without glue, analysis of variance (ANOVA) tests were carried out. No complications were observed. In general, the glue remnants remained visible at 3 and 6 weeks of implantation, accompanied by an inflammatory reaction and macrophage activity. At 12 weeks, all samples showed good tissue integration without evidence of glue. Evidently, the samples with glue demonstrated a prolonged inflammatory response and were surrounded by fibrous tissue capsules that were significantly thicker compared with the samples without glue (p < 0.05).

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Safety and efficacy of currently available fibrin tissue adhesives

Cited by 55 publications

References 10 publications

Tissue Adhesives as an Alternative for Conjunctival Closure in Strabismus Surgeries

Tissue Adhesives as an Alternative for Conjunctival Closure in Strabismus Surgeries

A new technique for management of intercavernous sinus bleeding with titanium clips in transsphenoidal surgery

Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue

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