“…Cryoablation requires long freeze cycles (2–4 minutes) to attain permanent tissue injury, which can be exploited to perform “cryomapping” where ablation can be interrupted if collateral tissue damage occurs. 12 Cryo-lesions may also cause less arterial intimal damage and stenosis than RF ablation, even when performed in very close proximity (<2 mm) to coronary arteries. 13 Caution is yet required, as acute and chronic arterial damage with cryoablation has been reported, 7 with animal models showing neointimal proliferation as a possible mechanism of injury.…”