Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trial

Development and application of a PBPK modeling strategy to support antimalarial drug development

“…Figure 5 includes more innovative applications of the models that are currently being conducted at MMV, such as predictions of PKs in special populations relevant to malaria and organ exposures. For example, a number of the models have been applied by us and independent researchers to predict lung concentrations as part of prioritizing candidates for drug re‐purposing to treat COVID‐19 17,42–45 . In these cases, existing “off‐the‐shelf” models were evaluated and the mechanistic lung model was incorporated allowing us to rapidly react to the pandemic prioritizing and planning clinical studies.…”

Efficacy and Safety of Favipiravir for the Treatment of COVID-19 Outpatients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

“…A total of 9 studies were included in our meta-analysis. [8][9][10][11][12][13][14][15][16] The detailed selection process is shown in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flowchart (see Figure 1, Supplemental Digital Content, http://links.lww.com/AJT/A139). One study included both inpatients and outpatients 10 while the rest of the studies included outpatients exclusively.…”

Unveiling the origin of the efficient photocatalytic degradation of nitazoxanide over bismuth (oxy)iodide crystalline phases

“…During the COVID-19 pandemic, nitazoxanide was used as a low-cost drug, and its active metabolite can inhibit the replication of both RNA and DNA, exhibiting action against various viruses, including SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2). 22 The extensive use of nitazoxanide for treating various diseases, including cryptosporidiosis, resulted in the detection of its traces in wastewater matrices due to its persistence, which stems from its poor permeability and solubility (7.55 mg L −1 ). 23 Therefore, it is important to find a novel approach to efficiently remove it from contaminated water and wastewater.…”