2014
DOI: 10.1016/j.joca.2014.02.703
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Safety and efficacy of FX006 in patients with osteoarthritis of the knee

Abstract: E2, 0.17 mg/kg body weight/day); and OVX with BHH10 in graded doses (250, 500, or 750 mg/kg/day). Daily oral administration of BHH10, ALN or E2 started on week 2 after OVX and continued for 12 weeks. Body and uterus weight, serum biochemical bone turnover markers, bone mineral density (BMD), and microarchitectural parameters were assessed. Results: BHH10 inhibited OVX-induced body weight gain, uterus atrophy, and significantly decreased levels of the bone formation markers serum alkaline phosphatase (ALP) and … Show more

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