Safety and Efficacy of Imiquimod in the Treatment of Infantile Hemangioma; a Systematic Review and Meta-Analysis

Alakeel, Abdullah

doi:10.15520/jcmro.v3i03.270

Cited by 1 publication

(2 citation statements)

References 47 publications

(74 reference statements)

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“… 23 Vincristine, IFNα and topical imiquimod have shown positive outcomes in treating IH and may be viable options in severe and recalcitrant IH. 23 , 104 – 106 However, the risks of neurotoxicity (e.g. cranial nerve palsy, spastic diplegia) are associated with vincristine and IFNα and local inflammatory changes (e.g.…”

Section: Reviewmentioning

confidence: 99%

“…ulceration) with imiquimod should be weighed against the benefit. 23 , 106 – 108 Other treatments (e.g. itraconazole, captopril, pingyangmycin, lauromacrogol/polidocanol, bleomycin, bevacizumab, brimonidine, sirolimus/rapamycin, deoxycholic acid) have also been mentioned in the literature but the recommendation for their use is limited due to relatively inferior efficacy, product availability or a lack of high-quality studies.…”

Section: Reviewmentioning

confidence: 99%

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Paediatrics: how to manage infantile haemangioma

Kim¹,

Lam²

2021

DIC

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Infantile haemangiomas (IHs) are relatively common benign vascular tumours found in the paediatric population. They have varying sizes and involve different depths in the skin leading to various colours, shapes and textures. Although considered harmless in most cases, they may lead to life-threatening complications or cause permanent disfigurations and organ dysfunction. For problematic IHs, the treatment options include oral and topical beta-blockers, systemic corticosteroids, laser treatment, and surgery. In this narrative review, the treatment options for problematic IH are compared and delivered concisely to facilitate the clinical decisions from practitioners, including those in primary care settings. Oral propranolol is currently considered the first-line intervention for problematic IHs. For superficial lesions, there is robust evidence for the use of topical timolol maleate. Systemic corticosteroids are sometimes used in specific situations such as resistance or contraindications to beta-blockers. Surgical excision can be considered in cases requiring urgent intervention such as airway obstruction; this can be done alongside laser therapies for the removal of residual tissue or when reconstructing areas of deformity. The combination of multiple treatment modalities may lead to a more rapid clinical response.

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