Safety and Efficacy of Intravitreal Preservative-Free Triamcinolone Acetonide (Triesence) for Macular Edema

Abstract

Intravitreal Triesence improves visual acuity and reduces macular thickness in eyes with macular edema from various causes. Treatment-associated IOP elevation was manageable with antiglaucoma medications. There were no serious vision-threatening complications associated with intravitreal Triesence therapy during the study period.

Diabetic macular oedema: pathophysiology, management challenges and treatment resistance

“…The triamcinolone group demonstrated a significant gain in vision at 2 years at the expense of increased cataract formation and elevated intraocular pressure (IOP), both common adverse events in trials evaluating intravitreal steroids [53]. Similar results have been found in other studies comparing triamcinolone with laser therapy [54,55].…”

Local delivery of corticosteroids in clinical ophthalmology: A review

“…Although acute bacterial endophthalmitis is the most serious complication of intraocularly administered steroids, acute non‐infectious endophthalmitis following IVTA injection is more common, with most studies reporting an incidence of 0.5% to 2.0% . Non‐infectious endophthalmitis refers to a transient, inflammatory reaction, typically with hypopyon that presents within a day or two post injection of IVTA .…”

“…Some authors have attributed non‐infectious endophthalmitis following IVTA injection to the preservative vehicle 0.99% benzyl alcohol found in Kenacort . In one study, the incidence of severe sterile endophthalmitis fell from 13.0% to 4.3% after switching from preserved to preservative‐free TA .…”

Sterile endophthalmitis after intravitreal injection of triamcinolone acetonide: case report and literature review

“…Incidence There are studies in the literature describing the administration of intravitreal triamcinolone acetonide for various pathologies of the posterior pole. The incidence of sterile endophthalmitis ranged from 0% to 23.8% in 14 studies [2][3][4][8][9][10][11][12][13][14][15][16][17][18] (Table 1). Clinical aspects Moshfeghi et al described a study with a total of 922 intravitreal injections of triamcinolone acetonide and 8 cases of sterile endophthalmitis.…”