“…In clinical studies, lorcaserin is well tolerated and decreases food intake and body weight (Smith et al, 2009(Smith et al, , 2010Chan et al, 2013;Aronne et al, 2014) at doses that have low potential for producing heart valve disease (Weissman et al, 2013) or abuse (Shram et al, 2011), effects commonly associated with 5-HT 2B and 5-HT 2A receptor agonists, respectively (Nichols, 2004;Hutcheson et al, 2011). In addition to preclinical studies demonstrating that lorcaserin decreases food intake and body weight (Smith et al, 2008;Thomsen et al, 2008;Higgins et al, 2013b;Grottick et al, 2015), lorcaserin is also shown to decrease nicotine selfadministration and the reinstatement of responding for nicotine in rats (Levin et al, 2011;Higgins et al, 2012Higgins et al, , 2013b.…”