Safety and efficacy of nesiritide use in an out-patient heart failure program: Initial results

Bhaskaran, Ambika; Siegel, Robert; Barker, Barbara; Nuttall, A. W.; Scagnelli, Sarah; Alder, Ryan; Rhodes, Michelle E.; Shimamoto, Steve J.; Vermillion, Jennifer

doi:10.1016/s1071-9164(03)00411-1

Cited by 2 publications

(3 citation statements)

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“…A number of small studies have reported that nesiritide can be used safely in the outpatient setting as an intermittent, short-term infusion (13)(14)(15). The FUSION trial randomized 210 patients with NYHA class III/IV heart failure to standard care (which could include intermittent inotropes) or outpatient nesiritide infusions (16).…”

Section: Nesiritide Use In Ambulatory and Ed Patientsmentioning

confidence: 99%

“…We will discuss these trials, briefly cover a few other nesiritide studies, and give our recommendations regarding nesiritide use in the ED. Other analyses of nesiritide, including a preliminary study vs. placebo (10) and several presentations in abstract form only, may have potential information applicable to the ED and will be discussed briefly as well (11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

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Critical review and recommendations for nesiritide use in the emergency department

Collins¹,

Hinckley²,

Storrow³

2005

The Journal of Emergency Medicine

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Section: Nesiritide Use In Ambulatory and Ed Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Critical review and recommendations for nesiritide use in the emergency department

Collins¹,

Hinckley²,

Storrow³

2005

The Journal of Emergency Medicine

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“…Patients were NYHA class III (36%) or IV (64%) initially, but 75% improved to class II with therapy. Hemodynamic improvement was associated with reduction in ventricular and atrial arrhythmias, reduced need for diuretics or IV inotropes, and improvement in renal function 37 …”

mentioning

confidence: 95%

Decompensated Heart Failure: Is There a Role for the Outpatient Use of Nesiritide?

Yancy

Burnett

Fonarow

et al. 2004

Congestive Heart Failure

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Heart failure (HF) management has seen enormous advances in the past two decades, including publication of HF management guidelines targeted at further reduction of morbidity and mortality. Nonetheless, the morbidity of HF has steadily increased and now represents one of the largest health care expenditures in this country. Because hospitalization for HF is most likely for patients with more advanced HF, they share a disproportionate burden of the hospitalization costs and will require treatment regimens beyond the current guidelines, if this burden is to be alleviated. In June 2004, a group of investigators who helped establish the natriuretic peptide treatment paradigm, met to discuss the potential role of nesiritide as an outpatient treatment option for patients with symptomatic HF who were at high risk for repeated admissions, a syndrome now described as "chronic decompensated HF." This report presents their considerations on the contribution of natriuretic peptide physiology to the amelioration of progressive left ventricular dysfunction, the therapeutic use of B-type natriuretic peptide, and its potential application to the outpatient management of acute and chronic decompensated HF. The use of outpatient IV nesiritide was considered a promising treatment option for symptomatic chronic decompensated HF patients that merits further investigation. Such an approach, once validated, should be integrated into an evidence-based HF disease management program.

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Safety and efficacy of nesiritide use in an out-patient heart failure program: Initial results

Cited by 2 publications

References 0 publications

Critical review and recommendations for nesiritide use in the emergency department

Critical review and recommendations for nesiritide use in the emergency department

Decompensated Heart Failure: Is There a Role for the Outpatient Use of Nesiritide?

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