Safety and efficacy of non-ablative CO2 laser treatment of vulvo-vaginal atrophy in women with history of breast cancer

Lami, Alessandra; Alvisi, Stefania; Baldassarre, Maurizio; Zanella, Sara; Amati, Veronica; Seracchioli, Renato; Meriggiola, Maria Cristina

doi:10.1007/s00404-023-07323-y

Arch Gynecol Obstet

2024

DOI: 10.1007/s00404-023-07323-y

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Safety and efficacy of non-ablative CO2 laser treatment of vulvo-vaginal atrophy in women with history of breast cancer

Alessandra Lami,

Stefania Alvisi,

Maurizio Baldassarre

et al.

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Cited by 2 publications

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Topical high concentration oxygen with hyaluronic acid: A safe and effective treatment for vaginal atrophy and sexual function improvement

Lami,

Manta,

Amati

et al. 2024

Post Reprod Health

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Background Genitourinary syndrome of menopause (GSM) is a condition affecting many postmenopausal women. Among the available treatments, the vaginal natural oxygenation device (VNOD) is a new promising option. Aim To evaluate the safety and the effectiveness of vaginal high concentration (HC) oxygen (O2) and hyaluronic acid (HA) in postmenopausal women with vaginal atrophy (VA). Methods Study 1: Ten subjects received HA and O2 at a concentration of 21% (sham group) and ten at 95% (treatment group). All subjects completed five sessions of VNOD. Evaluations and questionnaires were completed at baseline, before each session and at one-month follow-up: Visual Analogue Scale, Vaginal Health Index (VHI), Vaginal Maturation Value (VMV), Menopause Quality Of Life (MeNQoL), Female sexual function index (FSFI) and Female sexual distress scale (FSDS). Study 2: 52 postmenopausal women with VA completed the same protocol of study 1 with HC O2 and HA. Results Treatment was well-tolerated. In study 1, in the treatment group we recorded significant improvements in VHI score ( p-value 0.001), VMV ( p-value 0.005) and in the psychosocial, physical and sexual domains of the MeNQoL compared to sham group. In study 2, all women experienced a significant improvement in VHI ( p-value <0.001), FSFI total score ( p-value 0.007), desire ( p-value 0.004), lubrication ( p-value 0.006), satisfaction ( p-value 0.042), pain ( p-value 0.001) domains, FSDS score ( p-value 0.003) and MeNQoL sexual domain ( p-value <0.001). Conclusion The preliminary results of this study suggest that VNOD is a safe and effective treatment for VA in postmenopausal women, and improves sexual function.

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Topical high concentration oxygen with hyaluronic acid: A safe and effective treatment for vaginal atrophy and sexual function improvement

Lami,

Manta,

Amati

et al. 2024

Post Reprod Health

View full text Add to dashboard Cite

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The Use of Carbon Dioxide (Co2) Lasers in the Treatment of Vulvovaginal Atrophy Symptoms in Perimenopausal and Postmenopausal Women

Konac

2024

Journal of Innovative Healthcare Practices

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This study explores the efficacy of pixelated carbon dioxide (CO2) laser treatment in mitigating vulvovaginal atrophy symptoms among perimenopausal and postmenopausal women. With a cohort of 96 participants (mean age 47 ± 5 years), the research administered three sessions of vaginal CO2 laser treatment over three months. The primary evaluation metric was patient-reported satisfaction levels, aiming to assess the treatment's impact on alleviating symptoms associated with vulvovaginal atrophy, such as dryness, burning, and discomfort during intercourse. The findings revealed that 98% of the patients experienced significant symptom improvement three months post-treatment. Notably, 89% reported a resolution of sexual dysfunction due to vaginal dryness, and 96% indicated an end to discomfort and burning sensations. Patient satisfaction was remarkably high, with 98% of participants expressing contentment with the outcomes, a sentiment that persisted even one year after the treatment. Furthermore, 95% of the women encountered no discomfort during the procedure, and any post-treatment complaints were mild and temporary, with a watery discharge being the most common. The study concludes that pixel CO2 laser treatment is a practical, painless, and efficient approach for addressing vulvovaginal atrophy symptoms, yielding high patient satisfaction rates.

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Safety and efficacy of non-ablative CO2 laser treatment of vulvo-vaginal atrophy in women with history of breast cancer

Cited by 2 publications

References 48 publications

Topical high concentration oxygen with hyaluronic acid: A safe and effective treatment for vaginal atrophy and sexual function improvement

Topical high concentration oxygen with hyaluronic acid: A safe and effective treatment for vaginal atrophy and sexual function improvement

The Use of Carbon Dioxide (Co2) Lasers in the Treatment of Vulvovaginal Atrophy Symptoms in Perimenopausal and Postmenopausal Women

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