2014
DOI: 10.1016/j.jpain.2014.04.008
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Safety and Efficacy of Once-Daily Hydromorphone Extended-Release Versus Twice-Daily Oxycodone Hydrochloride Controlled-Release in Chinese Patients With Cancer Pain: A Phase 3, Randomized, Double-Blind, Multicenter Study

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Cited by 22 publications
(20 citation statements)
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“…They included, for example, an average of multiple current pain ratings from daily diaries (e.g., [11]), an average of multiple ratings of 24-hour recalled average pain (e.g., [12]), and an average of single ratings of different intensity domains (e.g., an average of the current pain, and 24-hour recalled least, worst, and average pain ratings from the Brief Pain Inventory [13]). Other domains assessed in these trials included current pain (assessed in seven trials [7,[14][15][16][17][18][19]), worst pain (assessed in five trials [7,8,[19][20][21]), and least pain (assessed in three trials [8,19,20]).…”
Section: Introductionmentioning
confidence: 99%
“…They included, for example, an average of multiple current pain ratings from daily diaries (e.g., [11]), an average of multiple ratings of 24-hour recalled average pain (e.g., [12]), and an average of single ratings of different intensity domains (e.g., an average of the current pain, and 24-hour recalled least, worst, and average pain ratings from the Brief Pain Inventory [13]). Other domains assessed in these trials included current pain (assessed in seven trials [7,[14][15][16][17][18][19]), worst pain (assessed in five trials [7,8,[19][20][21]), and least pain (assessed in three trials [8,19,20]).…”
Section: Introductionmentioning
confidence: 99%
“…Eleven of the studies were crossover trials (published in 16 articles),12 16–30 and 12 were parallel-group trials (published in 13 articles),13 31–42 with 8 of the studies conducted in the USA,16 17 20 21 29 30 33 35 36 39 2 in Canada,18 22 3 in Finland,23–25 3 in China,13 40 42 3 in Italy31 34 41 and one each in Germany/Poland/Switzerland,12 Australia,28 Brazil,27 the UK37 38 and Japan/Korea 32. The length of the trials ranged from single-dose treatment to 1 year, and the studies reported the following comparisons:CR oxycodone versus IR oxycodone29 30 33 36 39CR oxycodone versus extended-release (ER) oxycodone12CR oxycodone versus CR morphine,18 19 23 24 27 31 34 35 37 38 41 42 with one of these studies including a further two arms of transdermal (TD) buprenorphine and TD fentayl,31 and one of the studies comparing two different brands of slow-release morphine to CR oxycodone42CR oxycodone versus CR hydromorphone22CR oxycodone versus ER hydromorphone13CR oxycodone versus ER oxymorphone20 21CR oxycodone versus ER tapentadol32CR oxycodone versus TD fentanyl31 40CR oxycodone versus TD buprenorphine31intravenous oxycodone versus rectal oxycodone28intravenous oxycodone followed by IR oxycodone versus intravenous morphine followed by IR morphine25 26intramuscular (IM) oxycodone vs oral oxycodone16IM oxycodone versus IM morphine versus IM codeine 17…”
Section: Resultsmentioning
confidence: 99%
“…We limited imputation of missing data to the imputation of missing SDs, either by calculating the SD if enough information was available or by using SDs from similar samples or studies, both according to the methods outlined by Higgins and Green 11. We only imputed SDs for pain intensity for Lux et al ,12 which were not reported for the subgroup of participants with malignant pain, by using the reported SDs for the whole sample of participants with either malignant (n=31) or non-malignant pain (n=15), and for Yu et al 13 for the primary outcome of the study ‘mean pain at its worst in the past 24 hours’ by using the SDs for the same outcome measured at baseline in the full analysis set. It was not possible to assess the impact of missing data in sensitivity analyses due to the low number of included studies within each comparison.…”
Section: Methodsmentioning
confidence: 99%
“…Observation of the eligibility criteria led to the final selection of 32 research articles 2455 reporting the outcomes of the RCTs (Fig. 1).…”
Section: Resultsmentioning
confidence: 99%