Safety and efficacy of preoperative administration of meloxicam, compared with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery

Mathews, Karol A.; Pettifer, Glenn R.; Foster, Robert W.; McDonell, Wayne N.

doi:10.2460/ajvr.2001.62.882

Cited by 111 publications

(129 citation statements)

References 24 publications

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“…Many of the non-steroidal anti-inflammatory drugs (NSAIDs) have proven to be effective in controlling post-operative pain in dogs when used either alone or in combination with opioids [3,5,8,10,11,13]. However, the administration of NSAIDs may induce gastrointestinal toxicity, compromise renal blood flow, and/or cause hemostatic abnormalities as the results of inhibition of cyclo-oxygenase (COX).…”

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Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Kondo¹,

Takashima²,

Matsumoto³

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator's judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.

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Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Kondo¹,

Takashima²,

Matsumoto³

et al. 2012

The Journal of Veterinary Medical Science

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“…Diferentes escalas de dor são utilizadas para a avaliação do desconforto pós-operatório associado com a ovariosalpingohisterectomia por vários pesquisadores PETTIFER;FOSTER, 2001;MASTROCINQUE;FANTONI, 2003;SHIH et al, 2008;SELMI et al, 2009). Na medicina veterinária, o comportamento é frequentemente avaliado utilizando-se uma escala análoga visual ou uma escala numérica visual (MATHEWS; PETTIFER; FOSTER, 2001), mas alguns pesquisadores demonstraram que estes sistemas de avaliação são fracos indicadores da dor provenientes de traumas cirúrgicos (HARDIE; HANSEN; CARROLL, 1997).…”

Section: MIVunclassified

“…Os AINEs podem proporcionar analgesia por um período de até 24 horas, sendo administrados preferencialmente no período pré-operatório (PIBAROT et al, 1997;PETTIFER;FOSTER, 2001;MATHEWS, 2002). O cetoprofeno é um derivado do ácido propiônico, sendo considerado um potente agente anti-inflamatório e analgésico, pois inibe ambas isoformas da cicloxigenase (COX1 e COX2), a bradicinina e até certo ponto a lipoxigenase (MATHEWS, 1996;PIBAROT et al, 1997;MCFARLAND;SWANN, 2005) e está indicado para pacientes que cursam com dor de grau leve a moderado .…”

Section: Introductionunclassified

“…Estudos demonstram que a dose recomendada deste fármaco de 2,0 mg/kg é bem tolerada em cães, proporcionando duração de ação de aproximadamente 12 horas, sendo mínimos os efeitos colaterais provocados pelo seu uso (PIBAROT et al, 1997;PETTIFER;FOSTER, 2001;SELMI et al, 2009). Estudo em cães demonstra que este fármaco, quando empregado na pré-medicação pela via intramuscular, se mostrou efetivo para proporcionar recuperação anestésica isenta de fenômenos excitatórios, com adequada sedação, além de analgesia satisfatória durante a avaliação pós-operatória imediata (MATSUDA; FANTONI; FUTEMA, 1999).…”

Section: Introductionunclassified

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Avaliação clínica da analgesia pós-operatória proporcionada pelo cetoprofeno associado à morfina pela via intravenosa ou epidural em cadelas submetidas à ovariosalpingohisterectomia

et al. 2015

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ResumoA analgesia multimodal refere-se à prática de associar várias classes de analgésicos ou técnicas para atuar em diferentes pontos ao longo da via da dor. Objetivou-se avaliar clinicamente a qualidade da analgesia pós-operatória promovida pelo cetoprofeno, associado ou não à morfina pela via intravenosa ou epidural, em cadelas submetidas à ovariosalpingohisterectomia (OSH). Quarenta cadelas hígidas, pesando 10,7±6,0kg, tranquilizadas com acepromazina (0,05mg.kg -1 .iv), induzidas com propofol (5mg. kg -1 .iv) e mantidas sob anestesia inalatória com isoflurano, foram distribuídas em quatro grupos de 10 animais cada. Em Miv e CMiv as cadelas receberam após estabilização da anestesia inalatória, 0,2mg. kg -1 de morfina pela via intravenosa, diluídos em 10ml de salina; enquanto que os animais de Mep e CMep receberam 0,1mg.kg -1 de morfina pela via epidural. O cetoprofeno foi administrado na dose 2,0mg.kg -1 .im, nos grupos CMiv e CMep, 30 minutos após a medicação pré-anestésica. Mensuraram-se as frequências cardíaca (FC) e respiratória (f), pressão arterial sistólica (PAS), e temperatura retal (T). O grau de analgesia foi avaliado pelo método cego nas primeiras seis horas após a cirurgia, através de escalas de dor descritivas e escalas compostas por parâmetros fisiológicos e comportamentais. A estatística foi realizada mediante teste de Tukey-Kramer e análise não paramétrica de Kruskal-Wallis, com nível de significância de 5%. Não houve diferença estatística entre os quatro grupos estudados, em relação à analgesia pós-operatória, FC, f, PAS e T. De acordo com os resultados obtidos, pode-se concluir que o emprego do cetoprofeno, associado à morfina pela via intravenosa ou epidural proporcionou analgesia adequada e segura nas primeiras seis horas de analgesia pós-operatória em cadelas submetidas à OSH, sugerindo não haver potencialização analgésica quando da associação de ambos os agentes. Palavras-chave: Opióides, AINE, dor, cães AbstractMultimodal analgesia refers to the practice of combining multiple analgesic drug classes or techniques to target different points along the pain pathway. The objective of this work was to evaluate clinically if ketoprofen associated or not with intravenous or epidural morphine provided adequate postoperative analgesia in bitches undergoing ovariosalpingohysterectomy (OSH). Forty healthy female dogs,

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“…Meloxicam is another NSAID, and is a preferential inhibitor of the cyclooxygenase-2 enzyme (COX-2), high levels of which are expressed by abdominal and other tumours (see review by Mantyh et al 2002). The selectivity of meloxicam for COX-2 inhibition is thought to underlie its strong analgesic effects in alleviating signs of abdominal pain in rats (Roughan & Flecknell 2003), dogs (Mathews et al 2001) and cats (Slingsby & Waterman-Pearson 2000). Meloxicam was preferred to ketoprofen due to its more favourable gastrointestinal tolerance, an attribute also thought to be due to selective COX-2 inhibition (Engelhardt 1996).…”

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Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam

2004

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SummaryVery little is known concerning the occurrence of pain in cancer research models. We wished to establish whether a behaviour-based approach, originally developed to assess postoperative pain, could be used to determine positive effects of the analgesics carprofen and meloxicam in rats that might be experiencing pain during tumour development in an orthotopic model of bladder cancer. An invasive but non-metastatic rat bladder cancer cell line was surgically implanted into the bladder wall of 57 inbred Fisher344 rats. The rats underwent daily clinical assessments. When clinical signs consistent with chronic pain were apparent, behavioural data were collected from 44 animals during 2 3 10 min periods, immediately before and one hour after a subcutaneous injection of either physiological saline (0.9%; 0.2 ml/100 g), carprofen (5 mg/kg) or meloxicam (2 mg/kg). Treatmentassociated behaviour changes were then compared between groups. The lack of active behaviour, both before and after each treatment, was consistent with established clinical signs of pain. The rats were so inactive following the treatment that the behavioural technique we had previously developed was of comparatively little use in determining either pain severity or analgesic ef cacy. One very prominent effect, however, was an increase in ventral abdominal licking in the control (saline) group. As this was absent in rats given meloxicam or carprofen, and has previously been considered to indicate pain emanating from damaged tissue, it was concluded that the analgesic-treated rats gained at least some bene t from the drug treatments, but it was not possible to gauge the extent of this. Handling for examination or treatment may have intensi ed pain in rats in the control group, and so this should be avoided whenever possible. It is likely that post-surgical pain differs markedly from cancer pain, so a different set of behavioural markers may be needed to assess it effectively. More intensive behaviour monitoring may help to develop a suitable technique for detecting the onset of, and assess the severity of pain that may occur during tumour development.

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Safety and efficacy of preoperative administration of meloxicam, compared with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery

Abstract: Results suggest that preoperative administration of meloxicam is a safe and effective method of controlling postoperative pain for 20 hours in dogs undergoing abdominal surgery; the analgesic effects of meloxicam were comparable to those of ketoprofen and superior to those of butorphanol.

Cited by 111 publications

References 24 publications

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Efficacy and Safety of Firocoxib for the Treatment of Pain Associated with Soft Tissue Surgery in Dogs under Field Conditions in Japan

Avaliação clínica da analgesia pós-operatória proporcionada pelo cetoprofeno associado à morfina pela via intravenosa ou epidural em cadelas submetidas à ovariosalpingohisterectomia

Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam

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