Safety and efficacy of CO₂ dot matrix laser combined with platelet‐rich plasma on depressed scar after acne vulgaris and influencing factors of its repair effect: A retrospective analysis

Abstract

Background Acne vulgaris (AV) is the most pervasive inflammatory disease of hair follicle and sebaceous gland in the dermatology department, and depressed scar (DS) is the most common and serious sequela of AV. Aims To explore the clinical value of CO2 dot matrix laser combined with platelet‐rich plasma (PRP)‐treated AV. Methods Total 81 patients with DS at the rear of AV from December 2018 to October 2019 were selected, randomly divided into observation group (OG, n = 39) and control group (CG, n = 42). Patients in the OG group were treated with CO2 dot matrix laser combined with PRP, and those in the CG group were treated with CO2 dot matrix laser. To observe clinical outcomes in both groups. Results According to experimental analysis, compared with the CG group, CO2 dot matrix laser combined with PRP can more strongly improve the clinical efficacy on patients, shorten the scar scabbing time and decrustation time, more effectively contributed to their scar repair, comfort, skin condition, psychological state and satisfaction, and reduced their pain. The subsequent follow‐up results also showed that patients in the OG group experienced better quality of life. Moreover, according to the logistic regression analysis, the course of disease, scar degree, and staying up late were independent risk factors for the repair effect, and the repair method of CO2 dot matrix laser combined with PRP was an independent protection factor. Conclusion To sum up, CO2 dot matrix laser combined with PRP can strongly enhance the scar repair effect, psychological state, and life quality of patients with DS after AV, so it is worth popularizing in clinical practice.

Ultrapulse carbon dioxide dot matrix laser for facial scar treatment: A meta‐analysis

“…A total of 419 articles were obtained from the relevant databases, and all were imported into NoteExpress literature management software; 187 duplicates were excluded, with 232 studies remaining. According to the inclusion and exclusion criteria, 168 articles were excluded by reading the titles and abstracts and 47 by carefully reading the full text; ultimately, 17 RCTs were included in the analysis 18–26,29–36 . The basic characteristics of the included studies are shown in Table 1.…”

“…According to the inclusion and exclusion criteria, 168 articles were excluded by reading the titles and abstracts and 47 by carefully reading the full text; ultimately, 17 RCTs were included in the analysis. 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 The basic characteristics of the included studies are shown in Table 1 . The 17 included RCTs were assessed for quality using the risk of bias assessment tool provided by the Cochrane Handbook, as shown in Figure 2 .…”

“…However, photothermolysis may also produce adverse reactions such as erythema, stinging, edema, and hyperpigmentation 16,17 . Moreover, although many studies on the treatment of facial acne with ultrapulsed carbon dioxide dot matrix lasers have been reported, their conclusions have not been consistent 18–26 . Accordingly, this meta‐analysis aimed to explore the efficacy of ultrapulsed carbon dioxide dot matrix laser treatment for facial acne depression scars and provide evidence‐based data as a reference for clinical practice.…”

The Biological Role of Platelet Derivatives in Regenerative Aesthetics

“…Guo and colleagues studied the clinical efficacy and safety of a CO 2 dot matrix laser combined with PRP. They concluded that combining the two techniques can strongly improve the scar repair efficacy and psychosocial health and quality of life in patients with acne scars [ 50 ].…”

Use of Plasma Gel as Autologous Collagen Biostimulator with Simplified Technique: Case Report

“…The matrix laser combined with PRP was an independent protective factor. They concluded that the CO2 matrix laser combined with PRP can strongly improve the scar repair effect, psychological state and quality of life of patients with acne vulgaris scars, so it is worth popularizing in clinical practice [25].…”