Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction

Kaplan, Steven A.; Reis, Rodolfo Borges dos; Kohn, Ira J.; Ikeguchi, Edward F.; Laor, Eliahu; Te, Alexis E.; Martins, Antônio Carlos Pereira

doi:10.1016/s0090-4295(98)00633-5

Cited by 272 publications

(109 citation statements)

References 11 publications

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“…Similarly, Corney et al (1993) reported that sexual dysfunction was common and chronic in patients who underwent radical hysterectomy. This is consistent with other studies that have demonstrated that surgical cancer interventions can cause sexual dysfunction in between 20% and 100% percent of patients (Kaplan et al, 1999;Yılmaz and Eryılmaz, 2004). According to the information obtained in our study, among patients who experienced sexual problems, commonly reported problems included dyspareunia (97.1%), vaginal dryness (97.6%), decreased sexual desire (91.1%) and difficulties with sexual arousal (92.9%) related to the treatment.…”

Section: Discussionsupporting

confidence: 93%

“…It has also been demonstrated that sexual dysfunction is common and chronic in patients who undergo radical hysterectomy (Shell, 2007). This is consistent with other studies that have demonstrated that surgical interventions can cause sexual dysfunction (Kaplan et al, 1999;Yılmaz and Eryılmaz, 2004).…”

Section: Introductionsupporting

confidence: 85%

“…The IFSF, which has been developed by Kaplan et al (1999) to consist of 9 questions, each item investigates the sexual functioning of the woman within the last 4 weeks. The reliability and validity testing of the scale in Turkish was performed by Yılmaz and Eryılmaz, in 2004.…”

Section: Instrumentsmentioning

confidence: 99%

“…Basak Demirtas 1 *, Gul Pinar 1,2 chemotherapy in addition to surgery and radiotherapy (CT+RT+Surgery) have also been shown to be associated with poor sexual functioning (Kaplan et al, 1999;Yılmaz and Eryılmaz, 2004;Demirezen, 2006;Incrocci and Jensen, 2013). It has also been demonstrated that sexual dysfunction is common and chronic in patients who undergo radical hysterectomy (Shell, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Determination of Sexual Problems of Turkish Patients Receiving Gynecologic Cancer Treatment: a Cross-sectional Study

Demirtaş

Pınar²

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 93%

Section: Introductionsupporting

confidence: 85%

Section: Instrumentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of Sexual Problems of Turkish Patients Receiving Gynecologic Cancer Treatment: a Cross-sectional Study

Demirtaş

Pınar²

2014

Asian Pacific Journal of Cancer Prevention

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“…13 Control group consisted of 20 normal sexually active women with a mean age of 39.779.3 (range: 35-42) y, selected from the voluntary and healthy female hospital staff. All women enrolled to this study had a regular sexual male partner for at least 6 months while women with a neurological disorder were excluded.…”

Section: Methodsmentioning

confidence: 99%

Does sexual dysfunction correlate with deterioration of somatic sensory system in diabetic women?

et al. 2003

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To evaluate genital and extragenital somatic sensory system in diabetic women using biothesiometry and investigate the relation with sexual dysfunction. A total of 30 diabetic women and 20 normal sexually active women as a control group were evaluated with a detailed medical and sexual history including Index of Female Sexual Function (IFSF) questionnaire. Somatic sensory system of all women enrolled to the study was assessed by biothesiometry and threshold sensory values of nine genital sites and 14 extragenital sites were analyzed. The IFSF score in diabetic women was 23.6 while it was 38.3 in the control group (o0.0005). For each genital as well as extragenital sites, the mean biothesiometric values were significantly higher in diabetics. The sensation of introitus vagina, labium minora and clitoris were found to be the most deteriorated genital sites in diabetic women. The difference between diabetic women with or without female sexual dysfunction (FSD) was not significant for biothesiometric values. Our data indicate that, somatic sensory system is affected by diabetes however sexual dysfunction does not always manifest.

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The Neurobiology of Sexual Function

Meston¹,

Frohlich²

2000

Arch Gen Psychiatry

369

234

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This article provides a review of the past and current literature on the neurobiology of sexual function. The influence of endocrine, neurotransmitter, and central nervous system influences on male and female sexual function are discussed for sexual desire, arousal, and orgasm or ejaculation stages of sexual responding. Endocrine factors reviewed include the following: androgens, estrogens, progesterone, prolactin, oxytocin, cortisol, and pheromones. Neurotransmitters and neuropeptides discussed include nitric oxide, serotonin, dopamine, epinephrine, norepinephrine, opioids, acetylcholine, histamine, and gamma-aminobutyric acid. Central nervous system influences on sexual function are discussed briefly with reference to brainstem regions, the hypothalamus, and the forebrain.

show abstract

Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction

Cited by 272 publications

References 11 publications

Determination of Sexual Problems of Turkish Patients Receiving Gynecologic Cancer Treatment: a Cross-sectional Study

Determination of Sexual Problems of Turkish Patients Receiving Gynecologic Cancer Treatment: a Cross-sectional Study

Does sexual dysfunction correlate with deterioration of somatic sensory system in diabetic women?

The Neurobiology of Sexual Function

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