Safety and efficacy of vitamin B2 (riboflavin 5′‐phosphate ester monosodium salt) for all animal species when used in water for drinking

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on vitamin B 2 in the form of riboflavin 5 0 -phosphate ester monosodium salt as an additive for all animal species for use in water for drinking. The additive under assessment is obtained from a source of riboflavin produced by Ashbya gossypii. No information was provided on the identity and characterisation of the production strain, and on whether or not it is a genetically modified microorganism. Therefore, in the absence of adequate information, it is not possible to perform an assessment of the safety of the production strain. Riboflavin 5 0 -phosphate ester monosodium salt 'per se' is considered safe for the target animals, consumers and the environment. In the absence of data regarding the identity and characterisation of the production strain, the FEEDAP Panel cannot conclude on the safety for the target species, consumers, users and the environment of the riboflavin 5 0 -phosphate ester monosodium salt under assessment. Similarly, in the absence of data, no conclusion can be reached on the safety of the product for the users. Riboflavin 5 0 -phosphate ester monosodium salt is regarded as effective in covering the animal's requirement when administered via water for drinking. and Tarres-Call J, 2018. Safety and efficacy of vitamin B 2 (riboflavin 5 0 -phosphate ester monosodium salt) for all animal species when used in water for drinking. EFSA Journal 2018;16(12):5531, 15 pp. https://doi.org/10.

Green Chemistry for Crosslinking Biopolymers: Recent Advances in Riboflavin-Mediated Photochemistry

“…RFP is frequently used as an alternative to RF to overcome its low solubility. RFP is a phosphate sodium salt of RF, which is also known as flavin mononucleotide, and the presence of a phosphate group significantly increases the water solubility to approximately 30 mg mL −1 ( Figure 1 a) [ 30 ]. Although RF and RFP have different water solubilities, they exhibit similar photochemical properties, such as the excitation wavelength, emission wavelength, and intensity; these characteristics render them useful as photoinitiators ( Figure 1 b) [ 31 ].…”

Safety and efficacy of feed additives consisting of Vitamin B2 (98%) and Vitamin B2 (80%) as riboflavin produced by Bacillus subtilis KCCM 10445 for all animal species (Hubei Guangji Pharmaceutical Co. Ltd.)

“…The FEEDAP Panel issued an opinion on the safety and efficacy of vitamin B 2 as riboflavin and riboflavin-5 0 -phosphate ester monosodium salt, produced by either B. subtilis DSM 17339 or B. subtilis DSM 23984 (EFSA FEEDAP Panel, 2016), another opinion on the safety and efficacy of vitamin B 2 (riboflavin) produced by Ashbya gossypii (EFSA FEEDAP Panel, 2018b) and an opinion on the safety and efficacy of vitamin B 2 (riboflavin 5 0 -phosphate ester monosodium salt) for all animal species when used in water for drinking (EFSA FEEDAP Panel, 2018c). The last one was related to the safety and efficacy of the feed additive consisting of vitamin B 2 /riboflavin produced by Eremothecium ashbyi CCTCCM 2019833 for all animal species (EFSA FEEDAP Panel, 2021) Riboflavin produced by fermentation using different production strains is currently authorised for its use in all animal species as a nutritional additive.…”

Safety and efficacy of a feed additive consisting of vitamin B2 (riboflavin) produced by Bacillus subtilis CGMCC 13326 for all animal species (Kempex Holland B.V.)

“…The FEEDAP Panel has adopted several opinions on the use of vitamin B2 as a feed additive. Two opinions related to the safety and efficacy of vitamin B2 (80%) as riboflavin produced by B. subtilis KCCM‐10445 for all animal species (EFSA FEEDAP Panel, 2014 , 2018a ); an opinion on the safety and efficacy of vitamin B2 as riboflavin and riboflavin‐5′‐phosphate ester monosodium salt, produced by either B. subtilis DSM 17339 or B. subtilis DSM 23984 (EFSA FEEDAP Panel, 2016 ); another opinion on the safety and efficacy of vitamin B2 (riboflavin) produced by Ashbya gossypii (EFSA FEEDAP Panel, 2018b ); another related to the safety and efficacy of vitamin B2 (riboflavin 5′‐phosphate ester monosodium salt) for all animal species when used in water for drinking (EFSA FEEDAP Panel, 2018c ); and the last one related to the safety and efficacy of vitamin B2 produced by Eremothecium ashbyi CCTCCM 2019833 (EFSA FEEDAP Panel, 2021 ).…”