Safety and Efficacy Profile of Oral Tranexamic Acid v/s Tranexamic Acid Soaks v/s Tranexamic Acid Cream in Treatment of Melasma – A Hospital Based Prospective Randomised Controlled Comparative Study

Patil, Shraddha J.

doi:10.18535/jmscr/v6i2.23

Cited by 3 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First study by Steiner et al demonstrated no significant difference between ID (4 mg/cc) injection and topical application of TXA regarding reduction in MASI score and colorimetry; however, patients’ self‐assessment showed higher percentage of satisfaction in mesotherapy group (66.7%) compared to topical therapy (37.5%) 17 . In the second study, higher reduction in MASI score (greater than 50% improvement) was demonstrated with TXA microinjection (4 mg/cc) compared to topical TXA (71.6% and 33.3%, respectively), but the result was not statistically significant 18 . On the contrary, a subsequent RCT by Badran et al reported significantly higher reduction in MASI score with different concentrations of TXA mesotherapy (4 mg/cc and 10 mg/cc) compared to topical TXA 10% cream (39.1%, 62.7%, and 4.2%, respectively).…”

Section: Discussionmentioning

confidence: 84%

“…The 4 mg/cc concentration showed significantly higher percentage of patient’s satisfaction compared to 10 mg/cc; while relapse was more frequent with 4 mg/cc versus 10 mg/cc (54.5% vs. 25%) 13 . Furthermore, higher percentage of pain was reported with 10 mg/cc concentration compared to 4 mg/cc (30% vs. 20%) 18 …”

Section: Discussionmentioning

confidence: 86%

“…Injections were performed at 1 mm depth and 1 cm distance by 28–30‐gauge insulin syringe. Follow‐up periods were between 1 and 12 months 7–33 . Based on published articles, significant reductions in melasma area and severity index (MASI) scores were reported with TXA mesotherapy, from 33.3% to 81.2%.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, TXA inhibits angiogenesis by suppression of VEGF, endothelin (ET)‐1, and IL‐8, while reducing the number of mast cells. It also causes competitive inhibition of tyrosinase (an important enzyme in melanogenesis) 7–33 …”

Section: Discussionmentioning

confidence: 99%

“…17 In the second study, higher reduction in MASI score (greater than 50% improvement) was demonstrated with TXA microinjection (4 mg/cc) compared to topical TXA (71.6% and 33.3%, respectively), but the result was not statistically significant. 18 On the contrary, a subsequent RCT by Badran et al reported significantly higher reduction in MASI score with different concentrations of TXA mesotherapy (4 mg/cc and 10 mg/cc) compared to topical TXA 10% cream (39.1%, 62.7%, and 4.2%, respectively). Irritation was reported in topical therapy group, and pain was reported in mesotherapy groups.…”

Section: Comparison Of Txa Mesotherapy With Oral Txamentioning

confidence: 92%

See 4 more Smart Citations

Safety and efficacy of mesotherapy in the treatment of melasma: A review article

Khalili

Amiri

Iranmanesh

et al. 2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Mesotherapy is a popular novel therapeutic modality that is defined as intradermal or subcutaneous microinjection of pharmaceutical compounds. Although this novel treatment method is used commonly in aesthetic dermatology, there is little information about details of injections, efficacy, and side effects of mesotherapy in melasma. Aim In this review, we evaluated efficacy and safety of various types of mesotherapy in the treatment of melasma. Method We searched Google Scholar, Medline, and PubMed for related articles with keywords “melasma” OR “chloasma” AND “mesotherapy” OR “injection.” Inclusion criteria were articles that evaluated intradermal injection of lightening drugs and published dates between January 2000 and September 2021. Exclusion criteria were articles in languages other than English or non‐human studies. Results Thirty‐three articles evaluated efficacy of mesotherapy in melasma, including 28 articles about tranexamic acid, 4 articles about vitamin C, 2 articles about glutathione, and 2 articles about triamcinolone. Conclusion Mesotherapy is a good alternative or adjunctive choice in patients who are refractory to first‐line therapy, patients with low compliance with everyday use of topical therapy, patients with contraindication to oral tranexamic acid therapy, or who wish short downtime and fast recovery period. Further studies with large sample sizes are required to determine ideal concentrations of mesotherapy substances and intervals between sessions and to evaluate the efficacy of different substances for mesotherapy as monotherapy compared to combination therapy and other treatment modalities for melasma.

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Comparison Of Txa Mesotherapy With Oral Txamentioning

confidence: 92%

See 3 more Smart Citations

Safety and efficacy of mesotherapy in the treatment of melasma: A review article

Khalili

Amiri

Iranmanesh

et al. 2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

Role of Mesotherapy in Dermatological Disorders

Limbana,

Sooknanan,

AlEdani

2024

Updates in Clinical Dermatology

View full text Add to dashboard Cite

Topical and Systemic Therapies in Melasma: A Systematic Review

Sarkar,

Handog,

Das

et al. 2023

Indian Dermatology Online Journal

View full text Add to dashboard Cite

Introduction: Melasma is an acquired disorder, which presents with well-demarcated, brown-colored hyperpigmented macules, commonly involving the sun-exposed areas such as the face. It is a chronic and distressing condition, affecting the patients' quality of life, and has been conventionally treated with “first-line” agents including hydroquinone (HQ) alone or as a part of a triple combination cream (TCC), while “second-line” options include chemical peels, and third line options include laser therapy. Materials and Methods: A systematic search was performed for all topical and systemic treatments for melasma up till May 4, 2021, using the PubMed and EMBASE databases, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The search terms “melasma” and “treatment” were used to search for the relevant articles on both these databases, and a total of 4020 articles were identified. After removing the duplicate entries and screening the titles, abstracts, and full-text articles, we identified 174 randomized controlled trials (RCTs) or controlled clinical trials. Results: Based on our review, HQ, TCCs, sunscreens, kojic acid (KA), and azelaic acid receive grade A recommendation. Further large-scale studies are required to clearly establish the efficacy of topical vitamin C, resorcinol, and topical tranexamic acid (TXA). Several newer topical agents may play a role only as an add-on or second-line drugs or as maintenance therapy. Oral TXA has a strong recommendation, provided there are no contraindications. Procyanidins, Polypodium leucotomos (PL), and even synbiotics may be taken as adjuncts. Discussion: Several newer topical and systemic agents with multimodal mechanisms of action have now become available, and the balance seems to be tipping in favor of these innovative modalities. However, it is worth mentioning that the choice of agent should be individualized and subject to availability in a particular country.

show abstract

Safety and Efficacy Profile of Oral Tranexamic Acid v/s Tranexamic Acid Soaks v/s Tranexamic Acid Cream in Treatment of Melasma – A Hospital Based Prospective Randomised Controlled Comparative Study

Cited by 3 publications

References 10 publications

Safety and efficacy of mesotherapy in the treatment of melasma: A review article

Safety and efficacy of mesotherapy in the treatment of melasma: A review article

Role of Mesotherapy in Dermatological Disorders

Topical and Systemic Therapies in Melasma: A Systematic Review

Contact Info

Product

Resources

About