Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions

Iezzi, Roberto; Posa, Alessandro; Caputo, Cosimo Tommaso; Leoni, Davide De; Sbaraglia, Fabio; Rossi, Marco; Tagliaferri, Luca; Valentini, Vincenzo; Colosimo, Cesare

doi:10.3390/life13030631

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…IRE is typically performed under general anesthesia with a full neuromuscular blockade to avoid muscular contraction caused by high-voltage electricity [ 42 , 43 ]. Gastric emptying by nasogastric tube and cardiac monitoring are also required [ 44 ].…”

Section: Loco-regional Therapiesmentioning

confidence: 99%

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Punzi

Carrubba

Contegiacomo

et al. 2023

Life

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; patients’ long-term survival is strictly linked to the surgical resection of the tumor but only a minority of patients (2–3%) have a resectable disease at diagnosis. In patients with surgically unresectable disease, interventional radiology is taking on an increasing role in treatment with the application of loco-regional percutaneous therapies. The primary purposes of this narrative review are to analyze the safety and efficacy of ablative techniques in the management of borderline resectable and locally advanced diseases and to underline the role of the interventional radiologist in the management of patients with distant metastases. The secondary purpose is to focus on the synergy between immunotherapy and ablative therapies.

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Section: Loco-regional Therapiesmentioning

confidence: 99%

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Punzi

Carrubba

Contegiacomo

et al. 2023

Life

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“…Preliminary single-center experience including five patients only seems to demonstrate its feasibility, safety and effectiveness for improving prognosis and quality of life of patients with unresectable peri hilar CCA [ 86 ]. When compared to IRE, being characterized by reduced field strength, ECT could also be performed under analgo-sedation, without significant pain or adverse events as well as complications and without the need of general anesthesia, allowing for rapid post-interventional recovery [ 87 ].…”

Section: Interventional Ablative Treatment For Iccamentioning

confidence: 99%

Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma

et al. 2023

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Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. There is a growing literature suggesting percutaneous ablative techniques for the management of patients with iCCA measuring ≤3 cm with contraindications to surgery as well as for recurrent or residual tumors aiming to provide local cancer treatment and control. Most used ablative therapies for iCCA include radiofrequency and microwave ablation with irreversible electroporation, cryoablation and reversible electroporation (electrochemotherapy) being less commonly encountered techniques. Due to the infiltrative margins of the lesion, there is a need for larger safety margins and ablation zone; multi-apparatus ablation or other variations of the technique such as balloon-assisted approaches can be utilized aiming to increase size of the zone of necrosis. The present review paper focuses upon the current role of percutaneous ablative techniques for the therapeutic management of iCCA. The purpose of this review is to present the current minimally invasive ablative techniques in the treatment of iCCA, including local control and survival rates.

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Optimal Dosing and Patient Selection for Electrochemotherapy in Solid Abdominal Organ and Bone Tumors

Martin,

Martin

2023

Bioengineering

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The primary aim of this study was to analyze studies that use electrochemotherapy (ECT) in “deep-seated” tumors in solid organs (liver, kidney, bone metastasis, pancreas, and abdomen) and understand the similarities between patient selection, oncologic selection, and use of new procedures and technology across the organ systems to assess response rates. A literature search was conducted using the term “Electrochemotherapy” in the title field using publications from 2017 to 2023. After factoring in inclusion and exclusion criteria, 29 studies were analyzed and graded based on quality in full. The authors determined key patient and oncologic selection characteristics and ECT technology employed across organ systems that yielded overall responses, complete responses, and partial responses of the treated tumor. It was determined that key selection factors included: the ability to be administered bleomycin, life expectancy greater than three months, unrespectability of the lesion being treated, and a later stage, more advanced cancer. Regarding oncologic selection, all patient cohorts had received chemotherapy or surgery previously but had disease recurrence, making ECT the only option for further treatment. Lastly, in terms of the use of technology, the authors found that studies with better response rates used the ClinporatorTM and updated procedural guidelines by SOP. Thus, by considering patient, oncologic, and technology selection, ECT can be further improved in treating lesions in solid organs.

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Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions

Cited by 4 publications

References 31 publications

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives

Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma

Optimal Dosing and Patient Selection for Electrochemotherapy in Solid Abdominal Organ and Bone Tumors

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