Safety and feasibility of balloon aortic valvuloplasty in non‐TAVI centers: The “BAV for life” experience

Attisano, Tiziana; Silverio, Angelo; Stabile, Eugenio; Briguori, Carlo; Tuccillo, Bernardino; Uccio, Fortunato Scotto di; Lorenzo, Emilio Di; Tesorio, Tullio; Giordano, Arturo; Calabrò, Paolo; Bigazzi, Maurizio Cappelli; Golino, Paolo; Scherillo, Marino; Vigorito, Francesco; Quaranta, Gaetano; Esposito, Giovanni; Mauro, Ciro; Musumeci, Giuseppe; Tarantini, Giuseppe; Galasso, Gennaro; Investigators, Bav for Life

doi:10.1002/ccd.27820

Cited by 12 publications

(12 citation statements)

References 22 publications

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“…BAV can be considered as a bridge‐to‐decision in high‐risk patients with AS 5 . Published studies have reported that low LV function is an independent predictor of mortality after BAV 6,7 . Additionally, aortic regurgitation after BAV due to the bicuspid anatomy was also factored in during the discussion.…”

Section: Discussionmentioning

confidence: 99%

“…5 Published studies have reported that low LV function is an independent predictor of mortality after BAV. 6,7 Additionally, aortic regurgitation after BAV due to the bicuspid anatomy was also factored in during the discussion. In our patient, as there was no evidence of ischemic or nonischemic cardiomyopathy, poor LV function was deemed secondary to severe AS.…”

Section: Introductionmentioning

confidence: 99%

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Transcatheter aortic valve replacement as a bridge to surgical aortic valve replacement in a younger patient with extremely high surgical risk

et al. 2020

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A 50-year-old man with decompensated aortic stenosis displayed significantly reduced ejection fraction, an ascending aortic aneurysm (55 mm in diameter), and bilateral giant bullae, and was evaluated as having extremely high surgical risk. Therefore, as a bridge to definitive treatment, he simultaneously underwent transcatheter aortic valve replacement (TAVR) and upper left lung lobectomy. His heart function recovered 6 months later and he underwent surgical aortic valve replacement (SAVR) and graft replacement of the ascending aorta. TAVR may serve as a bridge procedure before SAVR for aortic stenosis in younger patients with high surgical risk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcatheter aortic valve replacement as a bridge to surgical aortic valve replacement in a younger patient with extremely high surgical risk

et al. 2020

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“…Besides elective indications for BAV, it is nowadays pre‐dominantly performed as an emergency treatment in the critical ill due to decompensated AS 24‐26 . Those patients do not necessarily have an elaborate MDCT or a 3‐D TOE sizing protocol completed and morbidity and mortality, regardless of the interventional strategy, are extremely high.…”

Section: Discussionmentioning

confidence: 99%

Contemporary use of balloon aortic valvuloplasty and evaluation of its success in different hemodynamic entities of severe aortic valve stenosis

Piayda

Wimmer

Sievert

et al. 2020

Cathet Cardio Intervent

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Objectives: To evaluate outcome assessment of percutaneous balloon aortic valvuloplasty (BAV) in different flow and gradient patterns of severe aortic stenosis (AS). Background: The mean pressure gradient reduction after BAV is an often-used surrogate parameter to evaluate procedural success. The definition of a successful BAV has not been evaluated in different subgroups of severe AS, which were introduced in the latest guidelines on the management of patients with valvular heart disease. Methods: In this observational study, consecutive patients from July 2009 to March 2018 undergoing BAV were divided into normal-flow high-gradient (NFHG), low-flow low-gradient (LFLG), and paradoxical low-flow low-gradient (pLFLG) AS. Baseline characteristics, hemodynamic, and clinical information were collected and compared. Results: One-hundred-fifty-six patients were grouped into NFHG (n = 68, 43.5%), LFLG (n = 68, 43.5%), and pLFLG (n = 20, 12.8%) AS. Mean age of the study population was 81 years. Cardiogenic shock or refractory heart failure (46.8%) was the most common underlying reasons for BAV. Spearman correlation revealed that the mean pressure gradient reduction, determined by echocardiography, had a moderate correlation with the increase in the aortic valve area (AVA) in patients with NFHG AS (ρ: 0.529, p < .001) but showed no association in patients with LFLG (ρ: 0.017, p = .289) and pLFLG (ρ: 0.030, p = .889) AS. BAV as bridge to surgical or transcatheter aortic valve replacement was possible in 44.2% of patients, with no difference between groups (p = .070).

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“…In biomedical research, big data is used for electronic health record (EHR) considered “relevant” to the understanding of health and disease, including clinical, imaging, omic, data from internet use and wearable devices, and others (13). The basic principle is to make the whole biomedical practice “evidence generating” without the need to design and conduct ad hoc studies (13, 14). The most popular description for big data was proposed by Doug Laney in 2001 and is known in the academic world as the “3Vs”: volume, variety, and velocity (15).…”

Section: Big Health Data: What Are They?mentioning

confidence: 99%

Big Health Data and Cardiovascular Diseases: A Challenge for Research, an Opportunity for Clinical Care

et al. 2019

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Cardiovascular disease (CVD) accounts for the majority of death and hospitalization, health care expenditures and loss of productivity in developed country. CVD research, thus, plays a key role for improving patients' outcomes as well as for the sustainability of health systems. The increasing costs and complexity of modern medicine along with the fragmentation in healthcare organizations interfere with improving quality care and represent a missed opportunity for research. The advancement in diagnosis, therapy and prognostic evaluation of patients with CVD, indeed, is frustrated by limited data access to selected small patient populations, not standardized nor computable definition of disease and lack of approved relevant patient-centered outcomes. These critical issues results in a deep mismatch between randomized controlled trials and real-world setting, heterogeneity in treatment response and wide inter-individual variation in prognosis. Big data approach combines millions of people's electronic health records (EHR) from different resources and provides a new methodology expanding data collection in three direction: high volume, wide variety and extreme acquisition speed. Large population studies based on EHR holds much promise due to low costs, diminished study participant burden, and reduced selection bias, thus offering an alternative to traditional ascertainment through biomedical screening and tracing processes. By merging and harmonizing large data sets, the researchers aspire to build algorithms that allow targeted and personalized CVD treatments. In current paper, we provide a critical review of big health data for cardiovascular research, focusing on the opportunities of this largely free data analytics and the challenges in its realization.

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Safety and feasibility of balloon aortic valvuloplasty in non‐TAVI centers: The “BAV for life” experience

Abstract: BAV is a safe and effective procedure that can be performed by trained operators in centers not performing TAVI.

Cited by 12 publications

References 22 publications

Transcatheter aortic valve replacement as a bridge to surgical aortic valve replacement in a younger patient with extremely high surgical risk

Transcatheter aortic valve replacement as a bridge to surgical aortic valve replacement in a younger patient with extremely high surgical risk

Contemporary use of balloon aortic valvuloplasty and evaluation of its success in different hemodynamic entities of severe aortic valve stenosis

Big Health Data and Cardiovascular Diseases: A Challenge for Research, an Opportunity for Clinical Care

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