Safety and feasibility of cardiopulmonary exercise testing in patients with advanced cancer

Effects of Aerobic Exercise Training in Anemic Cancer Patients Receiving Darbepoetin Alfa: A Randomized Controlled Trial

“…To determine VO 2peak , a physician-supervised maximal exercise test with 12-lead electrocardiogram monitoring (Mac 5000, GE Healthcare, Milwaukee, Wisconsin) was performed. The specific protocol for this test has previously been reported in detail [19]. In brief, the test was performed on an electronically braked cycle ergometer (Ergoselect 100; Ergoline, Bitz, Germany) with breath-by-breath expired gas analysis continuously measured on a calibrated metabolic measurement system (CPX/D system; Medgraphics, St. Paul, MN).…”

Pulmonary Rehabilitation in lung cancer

“…However, it appears clear that, in NSCLC patients, exercise capacity is greatly reduced: Jones reported that in these subjects, the mean peak VO 2 was 33% that of predicted [32], concluding that the Cardiopulmonary Exercise Test (CPET) represents an accurate parameter in evaluating the fitness of selected patients with NSCLC. The same author has subsequently shown that the reduction in exercise capacity is a strong predictor of mortality, which is regarded as the VO 2 peak [33], or the MET'S products or meters walked to the walk test [34].…”

Erratum to: Exercise Therapy in the Management of Solid Tumors

“…In order to summarize, the majority of studies were conducted in women The benefit of exercise on mortality in colon cancer may be influenced by tumor molecular expression of p27 21 Figure 1. Exercise-oncology research timeline 74 Erratum with early breast cancer with fewer studies in non-small lung cancer (NSCLC), hematologic malignancies, or mixed cancer populations. Exercise modality consisted of aerobic training alone, resistance training alone, or the combination of aerobic and resistance training prescribed at a moderate-vigorous intensity (50-75% of baseline maximum heart rate or cardiorespiratory fitness), 3 sessions or more per week, for 10-60 min per exercise session.…”

“…The studies by our group, and by others found that VO 2peak is a predictor of left ventricular function, cardiovascular disease risk factors (eg, blood pressure, lipid profile, c-reactive protein), as well as global QOL, fatigue, and other psycho-social outcomes in patients with solid malignancies. [41,[72][73][74][75][76][77] Exercise training is acknowledged as the most effective method to improve VO 2peak in healthy adults and such improvements may, in turn, reverse certain therapy-late effects. Accordingly, there has been increasing clinical and research interest in the role of exercise in cancer survivorship [7].…”