Safety and feasibility of inspiratory muscle training for hospitalized patients undergoing hematopoietic stem cell transplantation: a randomized controlled study

Almeida, Leonardo Barbosa de; Trevizan, Patrícia Fernandes; Laterza, Mateus Camaroti; Neto, Abrahão Elias Hallack; Perrone, Ana Carolina Amaral de São José; Martinez, Daniel Godoy

doi:10.1007/s00520-019-05209-x

Cited by 18 publications

(59 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characteristics of the exercise interventions (Tables 2 and 3) were very diverse. In total, 15 studies [23,30,31,36,[38][39][40]42,[45][46][47][48][49]54,55] analysed the effects of an exercise program intervention in cancer patients before and after HSCT treatment, and 10 studies analysed the effects after HSCT [34,35,37,41,43,44,[50][51][52][53].…”

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

“…Supervision: Exercise programs were supervised by researchers in 21 studies [23,31,34,35,37,38,[40][41][42][43][44][45][46][47][49][50][51][52][53][54][55] and semi-supervised in 2 studies [36,48] and 2 studies was not supervised [30,36].…”

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

“…Frequency: A total of 13 studies (52%) performed exercise intervention 5 times per week [23,31,36,38,40,42,[44][45][46][47]52,54,55]; 5 studies (20%) performed intervention 3 times per week [34,37,48,49,51]; 3 studies (12%) increased the exercise frequency to 7 times per week [30,35,41]; and 3 studies (12%) exercised twice per week [43,50,53]. Only 1 study (4%) did not report exercise frequency [39].…”

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

“…Intensity training: Six studies (24%) did not adequately report intensity exercise [30,39,41,44,45,54], two studies (8%) offered no information regarding strength training [34,43] and one study (4%) did not report information regarding aerobic training [52]. In 10 studies (40%), the intensity exercise was evaluated using a perceived exertion scale (RPE) [31,36,37,39,40,42,[47][48][49]51], 7 studies (32%) reported aerobic intensity exercise using a percentage of heart rate maximal (HRmax) [23,31,34,40,42,43,46], 3 studies (12%) reported intensity using a percentage of 1 repetition maximum (1RM) [50,52,53], 3 studies (12%) reported aerobic intensity exercise using a percentage of power [38,50,53], and 2 studies (8%) reported the intensity exercise using a percentage of maximal inspiratory pressure (MIP) [35,55].…”

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review

Morales-Rodriguez

Pérez-Bilbao

Juan

et al. 2022

IJERPH

View full text Add to dashboard Cite

This study looks at the effects of exercise programs on physical factors and safety in adult patients with cancer and hematopoietic stem cell transplantation (HSCT) or bone marrow transplantation (BMT). A systematic search was performed in the PubMed and Web of Science databases (from inception to 26 August 2021). A review was carried out following the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) checklist. The methodological quality of the included studies was assessed with the Physiotherapy Evidence Database (PEDro) scale, based, in turn, on the Delphi list. A total of 25 randomized controlled trials studies were included, comprising 1434 patients. The most significant result of this systematic review is that exercise program interventions are safe and produce positive changes in cardiorespiratory fitness, muscle strength, and the functional mobility-state in adult patients with cancer and HSCT or BMT. Only 3 patients from the 711 participants in the exercise interventions (i.e., 0.42%) reported adverse events related to exercise interventions. Moreover, exercise training programs may have a cardiological and muscular protective effect, as well as a healthy effect on the prevention and control of transplant complications, improving health outcomes.

show abstract

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

Section: Characteristics Of Exercise Interventionsmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review

Morales-Rodriguez

Pérez-Bilbao

Juan

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Adverse events were monitored according to the Common Terminology Criteria for Adverse Events (CTCAE) v4.0. If less than 5% of adverse events were observed during or after the intervention, the IMT protocol was considered as safe (de Almeida et al, 2020).…”

Section: Outcome Measures Feasibility Adherence and Safetymentioning

confidence: 99%

Feasibility and Efficacy of Inspiratory Muscle Training in Patients with Head and Neck Cancer receiving Concurrent Chemoradiotherapy

Vira

Samuel

Rai

et al. 2021

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Objectives: Patients with head and neck cancer (HNC) undergoing concurrent chemoradiotherapy (CCRT) often experience pulmonary symptoms. This study evaluated if a 7-week inspiratory muscle training (IMT) program during CCRT is feasible, adherent, and safe in patients with HNC. This study also evaluated the effect of IMT on diaphragm thickness, mobility, and cardiorespiratory parameters in patients with HNC receiving CCRT. Methods: Ten participants with advanced stage HNC receiving CCRT were recruited for the study. Feasibility, adherence, and safety of the intervention were the primary outcomes. Changes in diaphragm thickness and mobility, maximal inspiratory pressure, maximal expiratory pressure, forced vital capacity, forced expiratory volume in first second and functional capacity using 6-MWT were measured at baseline and post 7 weeks of CCRT. IMT was performed at one session per day for 5 days a week for 7 weeks. Eight sets of two minutes of inspiratory manoeuvres with one minute rest period between them with intensity of 40% MIP were given. Results: Ten participants were included in this study out of the 13 patients screened, indicating the feasibility to be 76.9%. Participants completed a total of 260 training sessions out of the 350 planned sessions denoting the adherence level as 74%. Diaphragm thickness and MEP remained significantly unchanged while significant decline was seen in diaphragm mobility, MIP,FVC, FEV1 and 6-MWD at the end of 7 weeks. No adverse events were reported following the intervention. Conclusion: Inspiratory muscle training did not show significant effect on the diaphragm thickness, mobility, and cardiorespiratory parameters; however, it was feasible, adherent, and safe in patients with HNC receiving CCRT.

show abstract

InspireGBs – Inspiratory muscle training in people with Guillain‐Barré syndrome: A feasibility study

Almeida,

Winck,

Marques

2024

PM&R

View full text Add to dashboard Cite

BackgroundGuillain‐Barré syndrome (GBS) is a rare immune‐mediated peripheral nerve disease often preceded by infections. Respiratory muscle weakness is a common complication in this population, leading to decreased vital capacity, weakened coughing ability, atelectasis, and pulmonary infections. Inspiratory muscle training (IMT) has been widely used to enhance inspiratory muscle strength and pulmonary function in various diseases; however, its application in GBS is unknown.ObjectiveTo assess the safety, feasibility, and preliminary effectiveness of an IMT protocol—InspireGBs—in people with GBS.MethodsA pre/post feasibility study was conducted. Feasibility was determined by participant recruitment/retention, adherence, time spent in each session, and adverse events. Secondary outcome was inspiratory muscle strength. InspireGBs consisted of twice daily sessions 5 times/week, three sets of 10 breaths in each session, for 6 weeks. Initial resistance was set at 50% of participant's baseline maximal inspiratory pressure (MIP) and with a weekly increase of 10% calculated from the previous week's training intensity, if tolerated, otherwise the increase was 5%.ResultsEleven patients (63% male; 63 ± 9 years) were recruited from inpatient rehabilitation and 10 completed the study. Recruitment and retention rates were high (79% and 91%, respectively). Excellent adherence rate (96%) was obtained with no reported adverse effects or safety issues. Sessions lasted from 4 to 6 minutes. The MIP improved (pretraining: 39 [26.5–50] cm H2O vs. posttraining: 61 [56.3–64.5] cm H2O, p = .005 and pretraining: 38 [30.5–53.8] % of predicted vs. posttraining: 60 [54.28–71.58] % of predicted, p = .009) with the InspireGBs.ConclusionInspireGBs is safe, feasible, and may be effective in improving inspiratory muscle strength in individuals with GBS. A randomized controlled trial is now needed to strengthen these findings.

show abstract

Safety and feasibility of inspiratory muscle training for hospitalized patients undergoing hematopoietic stem cell transplantation: a randomized controlled study

Cited by 18 publications

References 34 publications

Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review

Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review

Feasibility and Efficacy of Inspiratory Muscle Training in Patients with Head and Neck Cancer receiving Concurrent Chemoradiotherapy

InspireGBs – Inspiratory muscle training in people with Guillain‐Barré syndrome: A feasibility study

Contact Info

Product

Resources

About