2009
DOI: 10.1159/000268743
|View full text |Cite
|
Sign up to set email alerts
|

Safety and Function of a New Clinical Intracerebral Microinjection Instrument for Stem Cells and Therapeutics Examined in the Göttingen Minipig

Abstract: Background: A new intracerebral microinjection instrument (IMI) allowing multiple electrophysiologically guided microvolume injections from a single proximal injection path in rats has been adapted to clinical use by coupling the IMI to an FHC microTargeting Manual Drive, designed to be used with standard stereotactic frame-based systems and FHC frameless microTargeting Platforms. Methods: The function and safety of the device was tested by conducting bilateral electrophysiologically guided microinjections of … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
28
0

Year Published

2011
2011
2019
2019

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 29 publications
(28 citation statements)
references
References 52 publications
0
28
0
Order By: Relevance
“…Distinct cell types can be precisely engrafted into brain substructures (Bjarkam et al, 2010), averting the acute and long-term systemic adverse effects seen with AEDs. Further, neural grafts, with their ability to integrate within the host circuitry, would circumvent the need for daily dosing and sluggish titration required with AED administration.…”
Section: Discussionmentioning
confidence: 99%
“…Distinct cell types can be precisely engrafted into brain substructures (Bjarkam et al, 2010), averting the acute and long-term systemic adverse effects seen with AEDs. Further, neural grafts, with their ability to integrate within the host circuitry, would circumvent the need for daily dosing and sluggish titration required with AED administration.…”
Section: Discussionmentioning
confidence: 99%
“…To date, cell delivery into the human brain has been performed on hundreds of patients enrolled in clinical trials for the treatment of neurodegenerative disorders using a similar type of straight cannula and syringe. There is a growing recognition that this cell delivery strategy has substantial shortcomings [18,20,24]. RBD provides solutions for several of the limitations that exist with the tools currently being used.…”
Section: Discussionmentioning
confidence: 99%
“…Cunningham and colleagues have also explored the concept of enhancing cell transplantation by using radial trajectories [22,24]. While their Intracerebral Microinjection Instrument (IMI) is capable of placing multiple cellular deposits radial to a single proximal brain penetration, the deflection angle achieved is 25 degrees, which limits the radial distance to about 8 mm.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…3 While much recent translational research has been focused on improving the quality and quantity of human cell types for transplantation, 4 there has been very little innovation of the surgical tools and techniques used for cell delivery to the human brain. [5][6][7][8][9][10][11] If unresolved, faults with cell delivery may contribute to the failure of clinical trials despite robust preclinical evidence and a compelling biological rationale.…”
Section: Introductionmentioning
confidence: 99%