Safety and immunogenicity of a quadrivalent human papillomavirus vaccine in HIV-infected and HIV-negative adolescents and young adults

Giacomet, Vania; Penagini, Francesca; Trabattoni, Daria; Viganò, Alessandra; Rainone, Veronica; Bernazzani, Giada; Bonardi, Claudia; Clerici, Mario; Bedogni, Giorgio; Zuccotti, Gian Vincenzo

doi:10.1016/j.vaccine.2014.08.011

Cited by 56 publications

(55 citation statements)

References 14 publications

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“…In those infected with human immunodeficiency virus (HIV), qHPV vaccine is highly immunogenic but induces lower GMTs which correlates with lower CD4 counts (<200) and with highly active anti-retroviral therapy (HAART) therapy improving response. 23-26 A suboptimal vaccine response to HPV vaccination was seen in kidney and other solid organ transplant recipients. 27 , 28 In children with a variety of immunosuppressive disorders, adequate immune response to vaccine was reported, but with lower GMT titers induced than in normal children.…”

Section: Discussionmentioning

confidence: 99%

The effect of history of abnormal pap smear or preceding HPV infection on the humoral immune response to Quadrivalent Human Papilloma virus (qHPV) vaccine in women with systemic lupus erythematosus

Dhar

Essenmacher

Dhar

et al. 2018

Human Vaccines & Immunotherapeutics

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Objective : To determine if natural human papillomavirus (HPV) infection would induce an anamnestic response to quadrivalent (qHPV) vaccine in women with Systemic Lupus Erythematosus (SLE). Methods: Thirty four women (19-50 years) with mild to moderate and minimally active or inactive SLE received standard qHPV vaccine. Neutralizing antibody titers to HPV 6, 11, 16 and18 were evaluated pre- and post- vaccine using HPV competitive Luminex Immunoassay. For each HPV type, logistic regressions were performed to explore the relationship between a positive titer at baseline with their final geometric mean titer and with the rise in titer. Fisher's Exact Test was used to assess the association of at least one positive HPV antibody test at baseline and history of abnormal pap. Results: History of abnormal pap smear/cervical neoplasia occurred in 52.9%. Baseline anti HPV antibody titers: 21% = negative for all 4 HPV types, 79% = positive for ≥1 of the HPV types. Statistical analysis showed: those with a history of abnormal pap smear/cervical neoplasia were likely to have a positive anti-HPV antibody result pre-vaccine to ≥ 1 of the 4 types, p = 0.035 Fisher's Exact Test. In general, HPV exposed women showed higher post vaccine GMTs than HPV unexposed women with higher point estimates. However, when examining the rise in titers using logistic regression, there was no evidence of an anamnestic response. Conclusion: Prior HPV infection and cervical neoplasia in SLE are linked with no anamnestic response to HPV vaccine. This supports not checking HPV-antibodies pre-vaccine. Women with SLE should be vaccinated for HPV.

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Section: Discussionmentioning

confidence: 99%

The effect of history of abnormal pap smear or preceding HPV infection on the humoral immune response to Quadrivalent Human Papilloma virus (qHPV) vaccine in women with systemic lupus erythematosus

Dhar

Essenmacher

Dhar

et al. 2018

Human Vaccines & Immunotherapeutics

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“…Selon une petite étude réalisée auprès de garçons et de filles infectés par le VIH, le VPH4 était sécuritaire et immunogène. Leurs titres d'anticorps au virus des types 6 et 18 étaient plus faibles que ceux observés chez des enfants du même âge non infectés par le VIH, mais on ne connaît pas encore la signification clinique de cette observation (16).…”

Section: Les Populations Particulièresunclassified

Le vaccin contre le virus du papillome humain chez les enfants et les adolescents

Salvadori

2018

Paediatrics &Amp; Child Health

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“…Seroconversion rates were similar (85% vs. 91%), and the antibody titer obtained 1 month after the third injection was lower than in seronegative controls. 84 A study carried out on the quadrivalent vaccine in HIV-infected men (median age of 44 years) has shown good vaccine immunogenicity without any impact on CD4 count or viral load. 85 The ACTG A5240 study was carried out on women aged 13 to 45 years who were stratified according to CD4 count and showed that the quadrivalent vaccine was well tolerated and resulted in high seroconversion rates; immunogenicity was lower in women with CD4 lymphocyte counts <200/mm 3 or a HIV viral load > 10 000 copies/mL.…”

Section: Human Papillomavirus (Hpv) Vaccinementioning

confidence: 99%

Immunization of HIV-infected adult patients — French recommendations

Frésard

Gagneux‐Brunon

Lucht

et al. 2016

Human Vaccines & Immunotherapeutics

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Human immunodeficiency virus (HIV)-infected patients remain at increased risk of infection including vaccine-preventable diseases. Vaccines are therefore critical components in the protection of HIV-infected patients from an increasing number of preventable diseases. However, missed opportunities for vaccination among HIV-infected patients persist and vaccine coverage in this population could be improved. This article presents the French recommendations regarding immunization of HIV-infected adults in the light of the evidence-based literature on the benefits and the potential risks of vaccines among this vulnerable population.

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Safety and immunogenicity of a quadrivalent human papillomavirus vaccine in HIV-infected and HIV-negative adolescents and young adults

Cited by 56 publications

References 14 publications

The effect of history of abnormal pap smear or preceding HPV infection on the humoral immune response to Quadrivalent Human Papilloma virus (qHPV) vaccine in women with systemic lupus erythematosus

The effect of history of abnormal pap smear or preceding HPV infection on the humoral immune response to Quadrivalent Human Papilloma virus (qHPV) vaccine in women with systemic lupus erythematosus

Le vaccin contre le virus du papillome humain chez les enfants et les adolescents

Immunization of HIV-infected adult patients — French recommendations

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