SAFETY AND IMMUNOGENICITY OF A NEW HAEMOPHILUS INFLUENZAE TYPE b VACCINE IN INFANTS UNDER ONE YEAR OF AGE

King, S. D.

doi:10.1016/s0140-6736(81)91045-x

Cited by 44 publications

(9 citation statements)

References 11 publications

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“…In a previous report the antibody responses of infants from Jamaica immunized with type b polysaccharide-pertussis vaccine were examined (29). In a pilot study for the present work, we measured Km(l) allotypes in serum samples remaining from nine black Jamaican infants who had been immunized at 2, 4, and 6 mo of age.…”

Section: Resultsmentioning

confidence: 99%

“…The vaccine (lots 7-1374-016A, 026A, and 039A) was supplied by Lederle Laboratories (Division of American Cyanamid Co., Pearl River, NY). Characterization of the vaccine (27) and its immunogenicity in laboratory animals (27,28) and humans (7,(29)(30)(31)(32) IgG and IgM anti-PRP antibody were measured by an enzymelinked immunosorbent assay using type b capsule-tyramine as described (7). Alkaline phosphatase conjugated goat anti-human IgG or IgM (heavy chain specific, Sigma Chemical Co., St. Louis, MO) were used for Ig detection.…”

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confidence: 99%

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Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.

Granoff¹,

Pandey²,

Boies³

et al. 1984

J. Clin. Invest.

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A bstract. In experimental animals, immune responses to certain antigens are regulated by immunoglobulin allotype-linked genes. In an effort to detect such genes in humans, we examined the antibody responses of 74 healthy children with different Km(l) or Gm(23) allotypes to a Haemophilus influenzae type b vaccine (type b polysaccharide capsule-pertussis vaccine). The anticapsular antibody responses of black or white children with the Km(1) allotype were 4.6-to 9.5-fold higher than those of children who lacked this determinant (P < 0.004). No significant differences were found in antibody response with respect to the Gm(23) allotype. The frequencies of Km(l) and Gm(23) also were examined in 170 patients with Haemophilus meningitis, 71 patients with epiglottitis, and 173 control children. Km(1) was detected less frequently in black patients with meningitis (38%) than in those with epiglottitis (81%, P < 0.002) or in controls (66%, P < 0.0007). The relative risk of meningitis thus was 3.2-fold lower among black children with the Km(1) allotype than in those who lacked this allotype (odds ratio = 0.3, 95% confidence interval 0.2 to 0.6). However, the risk of meningitis was not decreased in white children with the Km(l) allotype (odds ratio = 1.0). There were no significant differences in the frequency of Gm(23) among the patient groups and controls. The Km(l) allotype but

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.

Granoff¹,

Pandey²,

Boies³

et al. 1984

J. Clin. Invest.

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“…Moreover, in contrast to most viral and protein antigens, tiie humoral immune response to polysaccharide anligens, such as pneumococcai poiysaccharide or //. iitfluenzae type b capsular poiyribosyl-ribitoi phosphate (PRP) vaccines, is delayed in onset [17,26]. The regular laiiurc of children under 2 years of age and of elderly and morbid patients to respond to such materials has considerabie ciinicai significance.…”

Section: Discussionmentioning

confidence: 99%

Age‐Dependence of the IgA Anti‐α(1→3) Dextran B1355 Response in Vitro

1983

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The magnitude of the Balb/c mouse IgA anti-alpha (1 leads to 3) dextran B1355 (anti-dex) response in vivo was recently found to be markedly T-cell-dependent and age-dependent. This report demonstrates that the in vitro IgA anti-dex response by mesenteric lymph nodes (MLN) is highly age-dependent and that there is an age-dependent increase of the background IgA anti-dex plaque-forming cell (PFC) response occurring in the absence of added antigen which correlates significantly with the magnitude of the antigen-stimulated response. In aging mice both background and antigen-stimulated IgA anti-dex responses appeared to be significantly higher in MLN than in spleen cultures. Moreover, it is shown that there is a striking increase with age of natural antibody in the serum of normal Balb/c to alpha (1 leads to 3) glucan determinants, particularly IgA and lesser amounts of IgM and IgG3.

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“…This is because PRP-specific antibody responses are made by infants given PRP with their diphtheria-pertussistetanus (DPT) immunization. Under these circumstances, the petussis element may serve as an adjuvant for the PRP (King et al, 1981).…”

Section: Immunity After Birth: Infections and Immunizationsmentioning

confidence: 99%

Human Growth

1986

107

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SAFETY AND IMMUNOGENICITY OF A NEW HAEMOPHILUS INFLUENZAE TYPE b VACCINE IN INFANTS UNDER ONE YEAR OF AGE

Cited by 44 publications

References 11 publications

Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.

Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.

Age‐Dependence of the IgA Anti‐α(1→3) Dextran B1355 Response in Vitro

Human Growth

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