Safety and immunogenicity of booster immunization with 7-valent pneumococcal conjugate vaccine in children with idiopathic nephrotic syndrome

Liakou, Chrysoula; Askiti, Varvara; Mitsioni, Andromachi; Stefanidis, Constantinos J.; Theodoridou, Maria; Spoulou, Vana

doi:10.1016/j.vaccine.2013.11.106

Cited by 19 publications

(23 citation statements)

References 25 publications

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“…At the long term, a considerable decline in antibody titres was observed, especially in those infants with ongoing disease [ 4 , 47 , 51 ]. A PCV-7 repeated dose vaccination could provoke a significant increase in sero-titres, especially if not under treatment with immunomodulatory medications [ 50 ].…”

Section: Ckd Patients With Nephrotic Syndromementioning

confidence: 99%

The ABC of pneumococcal infections and vaccination in patients with chronic kidney disease: Table 1.

Vandecasteele¹,

Ombelet²,

Blumental³

et al. 2015

Clin Kidney J

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BackgroundIn the general population, pneumococcal polysaccharide vaccines (PPV) decrease the incidence of invasive pneumococcal disease (IPD) whereas the impact on the prevention of noninvasive pneumococcal disease is less clear. As compared with PPV, pneumococcal conjugate vaccines (PCV) provoke a higher, longer-lasting immune response resulting in a 45% decreased incidence in vaccine-type pneumonia, and a 75% decrease in vaccine-type IPD.MethodsLiterature review on pneumococcal vaccination in end-stage renal disease.ResultsAs compared with the general population, patients with chronic kidney disease (CKD) suffer increased mortality and morbidity from pneumococcal disease (PD), being up to 10-fold for those treated with dialysis. Numerous, usually small and methodological heterogeneous studies demonstrate that PPV provokes a serological response in dialysis patients, kidney transplant recipients, children with nephrotic syndrome and CKD patients receiving immunosuppressive medication. This response is of less intensity and duration than in healthy controls. Similar observations were made for the PCV. The protective value of these vaccine-elicited anti-pneumococcal antibodies in the CKD population remains to be substantiated. For patients treated with dialysis, epidemiological data demonstrate a correlation—which does not equal causality—between pneumococcal vaccination status and a slightly decreased total mortality. Clinical outcome data on the effectiveness of pneumococcal vaccination in the prevention of morbidity and mortality in the CKD population are lacking.ConclusionsAwaiting better evidence, pneumococcal vaccination should be advocated in all patients with CKD, as early in their disease course as possible. The ACIP schedule recommends a PCV-13 prime vaccination followed by a PPV-23 repeated vaccine at least 8 weeks later in pneumococcal non-vaccinated patients, and a PCV-13 vaccine at least 1 year after the latest PPV vaccine in previously vaccinated patients. In the UK, vaccination with PPV-23 only is recommended. There exist no good data supporting re-vaccination after 5 years in the dialysis population.

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Section: Ckd Patients With Nephrotic Syndromementioning

confidence: 99%

The ABC of pneumococcal infections and vaccination in patients with chronic kidney disease: Table 1.

Vandecasteele¹,

Ombelet²,

Blumental³

et al. 2015

Clin Kidney J

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“…Guidelines recommend that these children should have flu vaccinations to reduce the risk of having serious infections [ 4 ]. However, relapse of NS can reportedly occur after various vaccinations [ 5 – 10 ]. Although inactivated flu vaccinations could also precipitate relapses of NS [ 11 , 12 ], no data are available on the relative risk of NS relapse related to flu vaccines.…”

Section: Introductionmentioning

confidence: 99%

Influenza virus vaccination in children with nephrotic syndrome: insignificant risk of relapse

et al. 2020

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Background Immunization with various vaccines is considered desirable for children with idiopathic nephrotic syndrome (NS) because of their high risk of severe infections. Vaccinations may precipitate relapses of NS, but there is no available data regarding inactivated influenza (flu) virus vaccines. Methods We retrospectively reviewed the medical records of children with NS who had received flu vaccines between 2002 and 2015. The day of flu vaccination was defined as day 0, and the period between the pre-vaccination and the post-vaccination days was defined as − X to + Y. The risk ratios and their 95% confidence intervals for NS relapse rate were estimated by generalized estimating equation (GEE) Poisson regression. Results A total of 104 pediatric patients received 208 flu vaccines. The mean age at onset of NS was at 4.85 ± 3.87 years old. There were 261 NS relapses between days − 180 and + 180. Compared with the relapse rate in the − 180 to 0 interval (1.19 times/person-year), those in 0 to + 30 (1.23), + 31 to + 60 (1.58), + 61 to + 90 (1.41), + 91 to + 120 (1.41), and + 121 to + 180 (1.32) days groups were slightly increased, but without significance. Multivariate analysis using GEE Poisson regression also showed no significant increase in relapse rate in each day group compared with days − 180 to 0. Risk ratios for NS relapse were significantly higher in children who were treated with steroids at the first vaccination. Conclusions Our results suggest that flu vaccines should not be avoided in children with NS based on the potential for NS relapses. Electronic supplementary material The online version of this article (10.1007/s10157-020-01930-8) contains supplementary material, which is available to authorized users.

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“…7–11 Yet, HPV vaccine uptake in adolescent girls has not substantially increased over time while parental awareness has increased. 6,12,13 There is a need to understand how parental HPV vaccine awareness affects vaccine initiation and completion and whether vaccine uptake is mediated by other factors. The objective of this study was to examine the association between parental HPV vaccine awareness and vaccine initiation/completion among 13–17 year old US adolescents, and to explore whether these associations were mediated by provider recommendation.…”

Section: Introductionmentioning

confidence: 99%

Provider Recommendation Mediates the Relationship Between Parental Human Papillomavirus (HPV) Vaccine Awareness and HPV Vaccine Initiation and Completion Among 13- to 17-Year-Old US Adolescent Children

Rahman

Laz

McGrath

et al. 2014

Clin Pediatr (Phila)

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Objectives To examine the association between parental human papillomavirus (HPV) awareness and HPV vaccine initiation/completion based on 13–17 year old US adolescent children and to explore whether these associations were mediated by provider recommendation. Methods We used publicly available National Immunization Survey-Teen 2011 data (11,236 adolescent girls and 12,328 boys). Results Weighted logistic regression analysis showed that parental HPV awareness and provider recommendation predicted HPV vaccine initiation and completion separately among both girls and boys, after adjusting for demographic and healthcare utilization variables. When provider recommendation and parental HPV awareness were entered in the model simultaneously, only provider recommendation independently associated with HPV vaccine initiation and completion, demonstrating a mediation effect of provider recommendation. Conclusions Future studies are needed to better understand why physicians may not provide a recommendation for the HPV vaccine as well as to identify strategies to improve the provider’s ability to effectively communicate their recommendation.

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Safety and immunogenicity of booster immunization with 7-valent pneumococcal conjugate vaccine in children with idiopathic nephrotic syndrome

Cited by 19 publications

References 25 publications

The ABC of pneumococcal infections and vaccination in patients with chronic kidney disease: Table 1.

The ABC of pneumococcal infections and vaccination in patients with chronic kidney disease: Table 1.

Influenza virus vaccination in children with nephrotic syndrome: insignificant risk of relapse

Provider Recommendation Mediates the Relationship Between Parental Human Papillomavirus (HPV) Vaccine Awareness and HPV Vaccine Initiation and Completion Among 13- to 17-Year-Old US Adolescent Children

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