1993
DOI: 10.1093/infdis/168.6.1536
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Safety and Immunogenicity of Live Oral Cholera Vaccine Candidate CVD 110, a  ctxA ctxAzot zotace Derivative of El Tor Ogawa Vibrio cholerae

Abstract: The current pandemic of cholera is caused primarily by Vibrio cholerae O1 of the El Tor biotype. Live attenuated classical biotype V. cholerae vaccine strains prevent severe and moderate cholera due to either biotype in challenged volunteers but may provide less protection against mild cholera due to El Tor organisms. CVD 110, a new ctxA-deleted vaccine strain derived from an El Tor Ogawa parent, lacks zona occludens toxin (Zot), accessory cholera enterotoxin (Ace), and hemolysin/enterotoxin. Ten healthy adult… Show more

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Cited by 98 publications
(78 citation statements)
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“…Therefore, the degree of induction of these inflammatory genes may correlate with the level of reactogenicity in human volunteers. This is further supported by the finding that the El Tor vaccine strains JBK70 and CVD110, which were both very reactogenic in human volunteers (30,53), induced greater expression of these genes than strain CVD112 ( Fig. 1 and 7), which was less reactogenic in human volunteers (52).…”
Section: Discussionsupporting
confidence: 60%
“…Therefore, the degree of induction of these inflammatory genes may correlate with the level of reactogenicity in human volunteers. This is further supported by the finding that the El Tor vaccine strains JBK70 and CVD110, which were both very reactogenic in human volunteers (30,53), induced greater expression of these genes than strain CVD112 ( Fig. 1 and 7), which was less reactogenic in human volunteers (52).…”
Section: Discussionsupporting
confidence: 60%
“…Zot is an enterotoxin elaborated by V. cholerae that increases intestinal permeability by interacting with a mammalian cell receptor with subsequent activation of intracellular signaling, leading to the disassembly of the intercellular tight junctions (195). When a pI (Zot) or pVI (Ace) orthologue is seen in a genome sequence, this should not be an indication of a lysogenic conversion gene.…”
Section: Vibriomentioning
confidence: 99%
“…This experiment was possible because of the well described attenuated nature of V. cholerae strain CVD110, which lacks cholera toxin, and can be safely ingested by volunteers. However, it is still capable of causing infection (a mild version of that caused by ctx ϩ V. cholerae) as manifested by shedding of high numbers of V. cholerae in diarrheal stools and immunological responses typical of cholera (5). This reactogenicity (diarrhea and other symptoms) makes CVD110 unsuitable for vaccine purposes, but excellent for our goal of identifying genes induced in vivo in a human infection.…”
mentioning
confidence: 99%