Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy

DeGiorgio, Christopher M.; Hertling, Dieter; Curtis, Ashley; Murray, Diana; Markovic, Daniela

doi:10.1016/j.yebeh.2019.03.001

Cited by 17 publications

(9 citation statements)

References 11 publications

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“…On the other hand, as mentioned above, a few studies have reported that direct VitD supplementation could reduce the seizure frequency (22,62). Christiansen et al (72) reported VitD supplementation (4,000 IU/day) resulted in a mean seizure frequency reduction by 30% during the treatment.…”

Section: Discussionmentioning

confidence: 97%

“…The third and most interesting finding is that VitD supplementation not only corrected serum 25-OH-VitD levels in children with epilepsy, but also significantly reduced epileptic activity. A few studies also suggested that seizures could be well controlled by VitD supplementation ( 22 , 62 ). In this retrospective study, such findings might be further explained from different perspectives of VitD sources.…”

Section: Discussionmentioning

confidence: 99%

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Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

Dong

Guo

et al. 2022

Front. Nutr.

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ObjectiveTo compare the serum 25-OH-VitD levels, the major marker of vitamin D (VitD) status, between healthy children and children with epilepsy before initiation of and during anti-seizure medications (ASMs) treatment and to evaluate the potential influence factors on 25-OH-VitD levels. Another major aim was to assess the potential role of VitD supplementation.MethodsFor comparison, we finally enrolled and collected data from 6,338 healthy children presenting to Health Care Department and 648 children visiting primary care pediatricians with symptoms of epilepsy in Children’s Hospital of Nanjing Medical University from January 2019 to June 2021. The demographic and biochemical characteristics of each child were extracted from the hospital information system.ResultsSerum 25-OH-VitD levels in 648 children with epilepsy were significantly lower than those of 6,338 healthy children (P < 0.0001), and the percentage of VitD insufficiency and deficiency status in pediatric patients was 49.19%. Of note, the serum 25-OH-VitD levels in children with newly diagnosed epilepsy before receiving any ASMs treatment were also significantly lower than those in healthy controls. Interestingly, ASMs therapy, alone or in combination, did not consistently reduce baseline serum VitD levels in children with epilepsy. The lower serum VitD levels in pediatric patients than those in healthy children might be related to the disease itself, rather than the ASMs treatment. As expected, VitD supplementation substantially increased the serum 25-OH-VitD levels (P < 0.0001). More critically, children with epilepsy receiving VitD supplementation achieved good seizure control in our study.SignificanceIn this retrospective study, the childhood epilepsy before initiation of and during ASMs treatment decreased the serum 25-OH-VitD concentrations, suggesting a clear association between epileptic disease and the risk of VitD deficiency. ASMs coadministration and long-term valproic acid treatment did not worse VitD-deficiency status, but in the small group receiving VitD supplementation, there was a significant improvement in reduction of seizure frequency. Therefore, pediatric clinicians are urged to raise public awareness of epilepsy-associated VitD deficiency.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

Dong

Guo

et al. 2022

Front. Nutr.

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“…Die Korrektur des Vitamin-D-Mangels konnte die Anfallshäufigkeit um 40 % [17] bzw. 26,9 % [18] reduzieren.…”

Section: Michael Dawilsunclassified

Beeinflussung des M. Dupuytren über die Ernährung und Mikronährstoffversorgung

Dawils¹

2022

Praxis Handreha

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“…Vitamin D supplementation may improve serum biomarkers of liver function (tavakoli et al, 2019). Furthermore, safety and tolerability of vitamin D3 even high-doses oral vitamin D3 (5000 IU/day) was reported in some studies (DeGiorgio et al, 2019;Sheikhpour el., 2018).…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin D therapy on glycemic control and biochemical indices in type 2 diabetic patients: a randomized, clinical trial study

et al. 2021

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Introduction: The aim of the present study was to evaluate the effect of vitamin D on glycemic control and biochemical indices in type 2 diabetes. Methods: This randomized double blind placebo-controlled clinical trial was conducted on 80 patients with type 2 diabetes mellitus (T2DM) referred to Shahid Beheshti hospital. These patients were randomly classified into case and control groups. Case group consumed 50,000 IU of vitamin D once a week for 12 weeks and control group placebo. Biochemical and lipid parameters and vitamin D3 were measured in two groups. Glycosylated hemoglobin (HbA1c) was assessed by latex enhance immunoturbidimetric assay. Results: There was no significant difference between case and control groups in terms of age, sex, body mass index and used medications. The mean vitamin D level in case and control groups before intervention was 15.06 ±3.307 and 15.83± 2.509 ng/ml and after intervention was 49.77 ±15.73 and 14.91±3.13 ng/ml respectively. The mean fast blood sugar in case and control groups after intervention was 156.565±32.23 and 147.75±35.06 mg/dl, respectively. The mean HbA1c in case and control groups before intervention was 7.59± 0.39 % and 7.66± 0.38 % and after intervention was 7.26 ± 0.60 and 7.60 ± 0.38, respectively. Moreover, significant difference was seen between case (20.2± 5.74 IU/L) and control groups (23.35± 7.80 IU/L) in terms of alanine aminotransferase, after intervention. Conclusion: According to these findings, vitamin D supplementation possibly through decreasing HbA1C and hepatic alanine aminotransferase could improve diabetes complications.

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Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy

Cited by 17 publications

References 11 publications

Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

Beeinflussung des M. Dupuytren über die Ernährung und Mikronährstoffversorgung

The effect of vitamin D therapy on glycemic control and biochemical indices in type 2 diabetic patients: a randomized, clinical trial study

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Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy

Cited by 17 publications

References 11 publications

Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

Association between serum vitamin D status and the anti-seizure treatment in Chinese children with epilepsy

Beeinflussung des M. Dupuytren über die Ernährung und Mikronährstoffversorgung

The effect of vitamin D therapy on glycemic control and biochemical indices in type 2 diabetic patients: a randomized, clinical trial study

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Safety and tolerability of Vitamin D3 5000 IU/day in epilepsy