Safety and tolerance of the human milk probiotic strain Lactobacillus salivarius CECT5713 in 6-month-old children

Maldonado, J.; Lara-Villoslada, Federico; Sierra, Saleta; Sempere, Lluis; Gómez, María R.; Rodríguez, Juan Miguel Díaz; Bozá, J.; Xaus, Jordi; Olivares, Mónica

doi:10.1016/j.nut.2009.08.023

Cited by 63 publications

(68 citation statements)

References 25 publications

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“…In fact, fi nding L. salivarius in human feces is not surprising but the important point is discovering its probiotic property. L. salivarius is found growing naturally in the oral cavities (Busarcevic et al, 2008;Koll et al, 2008), intestines (Ryan et al, 2008), vagina (Juarez et al, 2002;Kilic et al, 2005;Vera et al, 2009), and feces of animals (Nemcova et al, 1997;Robredo and Torres, 2000) such as calves, chickens, pigs (Lahteinen et al, 2010;Yun et al, 2009) and humans (Maldonado et al, 2009). In addition, it was also found in the breast milk of mothers (Maldonado et al, 2010;Martin et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The L. salivarius strain is under consideration as a potential probiotic bacterium (Maldonado et al, 2009;Ocana et al, 1999a;Pascual et al, 1999) and is found in a number of commercial probiotic products (Phalakornkule andTanasupawat, 2006 2007). The production of hydrogen peroxide by L. salivarius CECT 5713 has been reported (Martin et al, 2006) and could inhibit the growth of S. aureus through its H 2 O 2 production (Ocana et al, 1999b).…”

Section: Discussionmentioning

confidence: 99%

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Isolation and characterization of Lactobacillus salivarius MTC 1026 as a potential probiotic

Tinrat

Saraya

Chomnawang

2011

J. Gen. Appl. Microbiol.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Isolation and characterization of Lactobacillus salivarius MTC 1026 as a potential probiotic

Tinrat

Saraya

Chomnawang

2011

J. Gen. Appl. Microbiol.

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“…More recently, its complete genome has been sequenced [18], and its genetic features, such as proteins potentially involved in human molecular mimetism, may explain its immunomodulatory, anti-inflammatory, and anti-infectious properties [19, 20]. Moreover, its safety and health beneficial effects have been proved in animal models and in human clinical assays [20–23]. More recently, L. salivarius PS2 has also been isolated from human milk and preliminary assays have shown similar traits and probiotic potential.…”

Section: Introductionmentioning

confidence: 99%

Development of a Potential Probiotic Fresh Cheese Using TwoLactobacillus salivariusStrains Isolated from Human Milk

Cárdenas

Calzada

Peirotén

et al. 2014

BioMed Research International

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Cheeses have been proposed as a good alternative to other fermented milk products for the delivery of probiotic bacteria to the consumer. The objective of this study was to assess the survival of two Lactobacillus salivarius strains (CECT5713 and PS2) isolated from human milk during production and storage of fresh cheese for 28 days at 4°C. The effect of such strains on the volatile compounds profile, texture, and other sensorial properties, including an overall consumer acceptance, was also investigated. Both L. salivarius strains remained viable in the cheeses throughout the storage period and a significant reduction in their viable counts was only observed after 21 days. Globally, the addition of the L. salivarius strains did not change significantly neither the chemical composition of the cheese nor texture parameters after the storage period, although cheeses manufactured with L. salivarius CECT5713 presented significantly higher values of hardness. A total of 59 volatile compounds were identified in the headspace of experimental cheeses, and some L. salivarius-associated differences could be identified. All cheeses presented good results of acceptance after the sensory evaluation. Consequently, our results indicated that fresh cheese can be a good vehicle for the two L. salivarius strains analyzed in this study.

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“…This includes a high survival rate when exposed to gastrointestinal tract conditions, bile salt hydrolase activity, adherence to mucus and intestinal cells, ability to stimulate the expression of mucin-encoding genes, and in vitro and in vivo antimicrobial, anti-inflammatory, and immunomodulatory properties Olivares et al 2006;Pérez-Cano et al, 2010). Furthermore, it has been shown to be well tolerated and safe in animal models (LaraVilloslada et al 2007) and in human clinical assays (Arroyo et al 2010;Jiménez et al 2008;Maldonado et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Lactobacillus salivarius CECT 5713, a strain isolated from human milk: from genotype to phenotype

Langa

Maldonado‐Barragán

Delgado

et al. 2012

Appl Microbiol Biotechnol

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Lactobacillus salivarius CECT 5713, isolated from human milk, has immunomodulatory, anti-inflammatory and antiinfectious properties, as revealed by several in vitro and in vivo assays, which suggests a strong potential as a probiotic strain. In this work, the relationships between several genetic features of L. salivarius CECT 5713 and the corresponding phenotypes were evaluated. Although it contains a plasmid-encoded bacteriocin cluster, no bacteriocin biosynthesis was observed, possibly due to a 4-bp deletion at the beginning of the histidine kinase determinant abpK. The genome of L. salivarius CECT 5713 harbours two apparently complete prophages of 39.6 and 48 kbp. Upon induction, the 48-kbp prophage became liberated from the bacterial genome, but no DNA replication took place, which resulted in lysis of the cultures but not in phage progeny generation. The strain was sensitive to most antibiotics tested and no transmissible genes potentially involved in antibiotic resistance were detected. Finally, the genome of L. salivarius CECT 5713 contained four ORFs potentially involved in human molecular mimetism. Among them, protein 1230 was considered of particular relevance because of its similarity with dendritic cell-related proteins. Subsequently, in vitro assays revealed the ability of L. salivarius CECT 5713 to stimulate the maturation of immature dendritic cells and to inhibit the in vitro infectivity of HIV-1.

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Safety and tolerance of the human milk probiotic strain Lactobacillus salivarius CECT5713 in 6-month-old children

Cited by 63 publications

References 25 publications

Isolation and characterization of Lactobacillus salivarius MTC 1026 as a potential probiotic

Isolation and characterization of Lactobacillus salivarius MTC 1026 as a potential probiotic

Development of a Potential Probiotic Fresh Cheese Using TwoLactobacillus salivariusStrains Isolated from Human Milk

Characterization of Lactobacillus salivarius CECT 5713, a strain isolated from human milk: from genotype to phenotype

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