Safety aspects of longitudinal administration of IGF-I/IGFBP-3 complex in neonatal mice

Prediction of severe retinopathy of prematurity using the WINROP algorithm in a birth cohort in South East Scotland

“…Recognition of infants at risk of severe ROP several weeks before the onset of ROP may provide an opportunity to explore postnatal preventive strategies. Early nutritional interventions (enteral and parenteral) might modify the course of ROP 22 23. Supplementation with IGF-1 and essential fatty acids is being investigated 24.…”

Effect of insulin‐like growth factor‐I during the early postnatal period in intrauterine growth‐restricted rats

“…In the present study, IUGR rats were treated using 2 mg/kg IGF‐I. Others have previously reported that similar doses increase bodyweight of mice without reducing blood glucose level . Here we chose to study neonatal rats during PND 3–11 because this time interval corresponds to the gestational state of human preterm infants.…”

“…Others have previously reported that similar doses increase bodyweight of mice without reducing blood glucose level. 30 Here we chose to study neonatal rats during PND 3-11 because this time interval corresponds to the gestational state of human preterm infants. Furthermore, the condition of pups and dams was stable during this time interval.…”

Dietary proteins and IGF I levels in preterm infants: determinants of growth, body composition, and neurodevelopment

“…Moreover, mice treated with IGF I seemed to have increased proliferation of immature oligodendrocytes, while the number of mature oligodendrocytes remained the same. This was hypothesized to possibly promote myelination at later stages when the immature oligodendrocytes mature and start myelinating (45). In addition, lipopolysaccharide induced brain inflammation in a mouse model led to lower IGF I levels and impaired myelination in the subcortical white matter (46).…”