Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of &amp;lt;i&amp;gt;Syzygium aromaticum&amp;lt;/i&amp;gt; in Albino Rats

Saeed, Twadu A.; Osman, Osman A.; Amin, A. E.; Badwi, S. M. A. El

doi:10.4236/abb.2017.811030

Cited by 6 publications

(9 citation statements)

References 27 publications

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“…Kazi et al (2017) also used CLP at 1 g/kg and observed no effects on AST, ALT, and ALP activity in rabbits. Moreover, the actions of AST and ALT showed no significant differences for all treatments in rats fed clove extract at 250 and 500 mg/kg diet (Saeed et al, 2017). In another study, Mustafa (2016) showed no significant differences in AST, ALT, and ALP enzyme concentrations in broiler chickens fed mixed essential oils (cloves, anise, and caraway) at a rate of 200, 400, and 600 mg/kg feed.…”

Section: Resultsmentioning

confidence: 94%

Effects of clove powder supplementation on performance, blood biochemistry, and immune responses in broiler chickens

Al-Mufarrej¹,

Fazea²,

Al-Baadani³

et al. 2019

SA J. An. Sci.

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The goal of this study was to evaluate the effects of clove (Syzygium aromaticum) supplementation levels on performance, blood parameters, and immune response of broilers. A total of 336 one-day-old broilers were assigned to one of eight treatments: 1% to 6% clove supplementation levels, a positive control (vaccinated) and a negative control (unvaccinated). Bodyweight gain, feed intake, feed conversion ratio, serum protein profile, and immune responses were measured weekly. Lymphoid organs were weighed at 21 and 35 days. Levels of dietary clove between 2% and 6% supplementation resulted in a gradual decrease in weight gain and feed intake with an increase in feed conversion ratio at two and three weeks, whereas those that received 4% to 6% supplementation had reduced weight gain and the 3% to 6% supplemented animals consumed the least amount of feed at four and five weeks. High levels of clove supplementation (4%, 5%, and 6%) resulted in reduced total serum protein and albumin and the greatest activity of aspartate aminotransferase at 35 days. Antibodies to viruses against which the birds had been vaccinated were not affected by different levels of clove supplementation compared with the positive control. However, they were increased in birds in the negative control group without vaccination. Relative weights of lymphoid organs were not affected by any treatments at 21 and 35 days. These results indicate that clove supplementation at levels greater than 2% can lead to negative effects on performance without improving the health of the liver and immune responsiveness of broilers.

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Section: Resultsmentioning

confidence: 94%

Effects of clove powder supplementation on performance, blood biochemistry, and immune responses in broiler chickens

Al-Mufarrej¹,

Fazea²,

Al-Baadani³

et al. 2019

SA J. An. Sci.

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“…Antiinflammatory activity of clove oil was studied in mice at a dose of 33 mg/kg body weight intraperitoneal in which clove oil significantly suppressed the increase paw thickness by 50.6 % compared with control mice at 3 h (Taher et al, 2015). Similarly, anti-inflammatory effect of ethanolic extract of S. aromaticum in carrageenan-induced paw edema in rats has been reported with significant decrease in the edema at efficacy rates of 79.41, 82.39 and 63.92 % at the dose of 500 mg/kg body weight at 2 nd , 4 th and 6 th h, respectively (Saeed et al, 2017). Nikoui et al (2017) studied the anti-inflammatory effect of clove oil in thirty adult male dogs which were divided into four groups after surgical incision on abdomen.…”

Section: Discussionmentioning

confidence: 71%

Anti-inflammatory activity of Syzygium aromaticum (L.) Merrill & Perry oil in carrageenan-induced paw edema in female rats

Humbal¹,

Sadariya²,

Prajapati³

et al. 2019

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The present study was planned to evaluate in vivo anti-inflammatory activity of Syzygium aromaticum (L.) Merrill & Perry oil (clove oil), following single dose oral administration @ 100, 250 and 500 mg/kg in female wistar rats by using carrageenan-induced paw edema model. Twenty five rats were divided randomly into 5 groups and each group consists of five female rats. All rats were injected subcutaneously with 0.1 ml of 10% w/v carrageenan suspension subcutaneously as a local acute edema inducer after 30 min subsequent to oral administration of clove oil. Rats of control groups were kept untreated. Rats of standard control group were treated orally with indomethacin @ 10 mg/ kg body weight as a reference standard drug. Rats of other three treatment groups were treated with clove oil @ 100, 250 and 500 mg/kg body weight, respectively. Edema was expressed as the increase in paw volume in ml and measured up to the tibiotarsal articulation. Volume of edematous paw was measured at 0 h (before treatment), 1, 2, 3, 4, 6 and 24 h after treatments. Increase in paw thickness was measured by using digital plethysmometer and per cent inhibition was calculated. The anti-inflammatory effect of clove oil was highest at 3 h (35.46 %) at the dose of 500 mg/kg. The anti-inflammatory effect of standard drug indomethacin (42.99 %) was higher than clove oil at 3 h. Clove oil at 3 h all doses gave higher anti-inflammatory effect. Clove oil showed dose dependent anti-inflammatory activity in female wistar rats.

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“…Various studies have proven the antimicrobial, antioxidant, anti-inflammatory, and anti-cancer effects of S. aromaticum. Anti-inflammatory effect of the alcoholic extract of oral S. aromaticum has been proven in animal studies without reported side effects (21). In a study, it was found that clove oil cream was effective in wound healing and decreasing sphincter pressure of the anus (22).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a combination of herbal gel versus topical diltiazem (2%) in chronic anal fissure healing: a randomized doubleblind clinical trial

Tavakoli-Dastjerdi

Motavasselian

Emami

et al. 2019

J Herbmed Pharmacol

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Introduction: Chronic anal fissure (CAF) is a common painful ailment that adversely affects quality of life. Nonsurgical treatments such as topical diltiazem are routinely administered to patients with CAF. However, diltiazem is associated with side effects such as headache and allergic reactions, which often lead to discontinuation of the treatment. The aim of this study was to determine the efficacy and safety of a topical Persian herbal remedy with analgesic, antiinflammatory and antiseptic properties versus topical diltiazem (2%) in CAF healing. Methods: In this randomized double-blind clinical trial, 70 patients with CAF were randomly divided into an intervention group receiving topical herbal medicine and control group receiving topical diltiazem (2%) for 6 weeks. Both groups were given lifestyle and dietary advice including adherence to a high-fiber diet, avoidance of spicy foods, use of a laxative (psyllium powder) in case of constipation, and taking sitz baths. Severity of pain, bleeding, and itching were measured at the first visit as well as the first, third, and sixth weeks of treatment. Wound healing and epithelialization were evaluated by anal examination. The treatment and follow-up period was 12 weeks; 6 weeks for assessing the effect of treatment and 6 weeks for examining treatment maintenance and evaluating the percentage of recurrence. Results: The herbal medicine caused significant reduction in pain compared with diltiazem (P < 0.001). The herbal medicine had a significant effect in terms of wound healing at the end of the period (P < 0.001). Recurrence rate was lower in the intervention group (32%) than the control group (56%), though this difference was not significant (P = 0.323) Conclusion: Findings of this clinical trial suggest a higher efficacy of the combination herbal remedy versus topical diltiazem 2% in the management of pain and wound associated with CAF.

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Safety Assessment and Potential Anti-Inflammatory Effect of Ethanolic Extract of <i>Syzygium aromaticum</i> in Albino Rats

Cited by 6 publications

References 27 publications

Effects of clove powder supplementation on performance, blood biochemistry, and immune responses in broiler chickens

Effects of clove powder supplementation on performance, blood biochemistry, and immune responses in broiler chickens

Anti-inflammatory activity of Syzygium aromaticum (L.) Merrill & Perry oil in carrageenan-induced paw edema in female rats

Efficacy of a combination of herbal gel versus topical diltiazem (2%) in chronic anal fissure healing: a randomized doubleblind clinical trial

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