Safety assessment of bio-synthesized iodine-doped silver nanoparticle wound ointment in experimental rats

Shittu, Oluwatosin Kudirat; Oluyomi, Olawale Issac; Gara, Theresa Yebo

doi:10.1186/s40816-021-00314-z

Cited by 3 publications

(4 citation statements)

References 37 publications

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“…4b-e). This is in contrast to the account by Shittu et al [49], who reported the unscathed nature of the hepatocytes after wound healing activity of silver nanoparticles. The PEG treated water groups revealed thrombosed and recanalized blood vessels and focal areas of necrosis (Fig.…”

Section: Histopathological Studiescontrasting

confidence: 99%

“…Hb and PCV are involved in the transport of nutrients and oxygen to tissues to enhance energy release for the body [48]. While, granulocytes are the innate immune system cells that have the ability to generate antibodies, fight microbial infections, respiratory complications and allergies [49,50]. MCV, MCH, MCHC are valuable parameters used in diagnosing different types off anaemia and monitoring toxicity that may alter blood or health status of an animal [46].…”

Section: Haematological Studiesmentioning

confidence: 99%

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Removal of contaminant in electroplating wastewater and its toxic effect using biosynthesized silver nanoparticles

2022

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This research is designed to remove contaminant in electroplating wastewater, using biosynthesize silver nanoparticles (SNPs) and to determine its in-vivo toxic effect. Silver nanoparticles (SNPs: 1,2,3 and 4) synthesized at different conditions and characterised, yielded spherical shapes of irregular sizes comprising of − OH, − C=C, − C=O, − C–H and − NO functional groups. The electroplating wastewater treated with the synthesized SNPs, were subjected to physicochemical analysis which revealed the ability of the SNPs to remove pollutants, with SNP4 displaying a higher affinity. The haematological investigation disclosed no significant impact on haemoglobin, packed cell volume, mean corpuscular haemoglobin concentration, red blood cell, neutrophils and lymphocytes compared to the control group. Although, the liver tissues revealed toxic effects of the treated wastewater. The study validates that the biosynthesized SNPs contained stabilizing and reducing agent and also has the ability to eliminate pollutant in electroplating wastewater. Article highlights Spherical shaped SNPs exhibits loosely bound properties and aggregation. SNPs contained functional groups acting as stabilizing and reducing agent. The SNPs treated wastewater had no significant impact on haemoglobin, packed cell volume and red blood cell in rats. The synthesized SNPs had the ability to remove contaminant from the electroplating wastewater.

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Section: Histopathological Studiescontrasting

confidence: 99%

Section: Haematological Studiesmentioning

confidence: 99%

Removal of contaminant in electroplating wastewater and its toxic effect using biosynthesized silver nanoparticles

2022

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“…Hb and PCV are involved in the transport of nutrients and oxygen to tissues to enhance the release of energy for the body (Isaac et al, 2013). Granulocytes are cells in the innate immune system that helps to ght microbial infections, respiratory complications, allergies and have the ability to generate antibodies by phagocytosis (Shittu et al, 2021;Okunlola et al, 2015).…”

Section: Studiesmentioning

confidence: 99%

Removal of Contaminant in Electroplating Waste Water and Its Toxic Effect Using Biosynthesized Silver Nanoparticles

Shittu

Gara

Onyinye

2022

Preprint

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The emergence of industries in developing countries is a rising challenge where the generation of undesirable liquid wastes containing pollutants are discharged into water bodies without adequate treatment. This research investigated the removal of contaminant in electroplating wastewater and its toxic effect using biosynthesized silver nanoparticles. Fresh leaves of Piliostigma thonningii were used to synthesize silver nanoparticles (Ag NPs). Dynamic light scattering (DLS), transmission electron microscope (TEM) and fourier transform infrared (FTIR) were used to characterize the produced Ag NPs. The electroplating wastewater was treated using green synthesized silver nanoparticle and subjected to physicochemical analysis using standard methods. The sub-chronic toxicity studies on the blood and liver tissues were carried out. At various conditions of concentration, temperature, pH and time, TEM showed the biosynthesized SNPs (1, 2, 3, and 4) to exhibit different particle size at 50 nm spherical shapes. FTIR revealed the presence of functional groups; -OH, -C = C, -C = O, -C-H and -NO. At different conditions, the SNPs demonstrated at the ability to remove pollutants in the electroplating wastewater with SNP4 displaying a higher affinity. In the toxicity evaluation of SNPs treated wastewater in rats, the heamatological parameters showed no significant influence on some parameters compared to the control group. However, the histopathological examination revealed toxic effects on the liver sections. It can be concluded that the biosynthesized Ag NPs contained functional groups that acts as stabilizing and reducing agent during the synthesis of Ag NPs had the ability to remove contaminant from electroplating wastewater.

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“…It should also be noted that silver is effective against multidrug-resistant strains [ 15 , 16 , 17 ]. High antibacterial activity has led to the wide use of silver nanoparticles in medicine for the treatment of textiles [ 18 ], the creation of dressings [ 19 ], antibacterial ointments [ 20 ], etc. However, unanchored silver nanoparticles can easily be removed from the carrier material during operation.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity and Sorption Behavior of Al2O3/Ag Nanocomposites Produced with the Water Oxidation of Bimetallic Al/Ag Nanoparticles

et al. 2022

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The water oxidation of bimetallic Al/Ag nanoparticles has been shown to yield nanoscale structures whose morphology, phase composition and textural characteristics are determined by the synthesis conditions. Flower-like nanoscale structures with silver nanoparticles, with an average size of 17 nm, are formed in water at 60 °C. Under hydrothermal conditions at temperatures of 200 °C and a pressure of 16 MPa, boehmite nanoplatelets with silver nanoparticles, with an average size of 22 nm, are formed. The oxidation of Al/Ag nanoparticles using humid air at 60 °C and 80% relative humidity results in the formation of rod-shaped bayerite nanoparticles and Ag nanoparticles with an average size of 19 nm. The thermal treatment of nanoscale structures obtained at a temperature of 500 °С has been shown to lead to a phase transition into γ-Al2O3, while maintaining the original morphology, and to a decrease in the average size of the silver nanoparticles to 12 nm and their migration to the surface of nanoscale structures. The migration of silver to the nanoparticle surface influences the formation of a double electric layer of particles, and leads to a shift in the pH of the zero-charge point by approximately one, with the nanostructures acquiring pronounced antimicrobial properties.

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Safety assessment of bio-synthesized iodine-doped silver nanoparticle wound ointment in experimental rats

Cited by 3 publications

References 37 publications

Removal of contaminant in electroplating wastewater and its toxic effect using biosynthesized silver nanoparticles

Removal of contaminant in electroplating wastewater and its toxic effect using biosynthesized silver nanoparticles

Removal of Contaminant in Electroplating Waste Water and Its Toxic Effect Using Biosynthesized Silver Nanoparticles

Antimicrobial Activity and Sorption Behavior of Al2O3/Ag Nanocomposites Produced with the Water Oxidation of Bimetallic Al/Ag Nanoparticles

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