Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine

Artificial rearing with docosahexaenoic acid and n-6 docosapentaenoic acid alters rat tissue fatty acid composition

“…It has been demonstrated previously that the AR-DHA1DPAn-6 group performed similarly to the DAM and AR-DHA groups in spatial task performance testing, although this effect was significantly different in ARDHA1DPAn-6 rats compared with AR-LA and AR-DPA rats for memory retention but not for escape latency (13). Administration of a 22:5n-6 plus 22:6n-3 oil to growing swine resulted in no adverse effects (34), and humans consuming a 22:5n-6 plus 22:6n-3 oil supplement had no adverse effect on cardiovascular disease risk (35). In an Alzheimer disease rat model, 22:5n-6 plus 22:6n-3 may decrease the efficacy of DHA treatment in reducing amyloid-b and -t accumulation, but 22:6n-3 plus 22:5n-6 may have a greater effect than DHA alone on reducing early-stage phosphor-t epitope levels (30).…”

Modification of Fatty Acid Composition in Meat Through Diet: Effect on Lipid Peroxidation and Relationship to Nutritional Quality – A Review

“…It′s well known that microalgae are the original source of DHA in the marine food chain [41], dried marine algae have also been included in animal feeds to improve the DHA level of foods of animal origin. Studies has mainly focused on the quality of eggs [42,43] and chicken meat [44].…”

Effects of a dietary supplement of DHA-rich marine algae on Italian heavy pig production parameters

“…Given that microalgae are the original source of DHA in the marine food chain (Abril et al, 2003), dried marine algae have also been included in animal feeds to improve the DHA level of foods of animal origin. Research has mainly focused on poultry and, more specifically, on the quality of eggs (HerberMcNeill andVan Elswyk, 1996 and1998;Van Elswyk, 1997;Abril and Barclay, 1998;Meluzzi et al, 2001) and chicken meat (Mooney et al, 1998;Abril and Barclay, 1998;Sirri et al, 2003).…”