Safety assessment of genetically engineered potatoes with designed soybean glycinin: compositional analyses of the potato tubers and digestibility of the newly expressed protein in transgenic potatoes

Toxicity Studies of Genetically Modified Plants: A Review of the Published Literature

“…Would this Richards et al (2003) period be sufficient to detect relevant toxicological changes on rats small intestine? Hashimoto et al (1999a) confirmed that transgenic potatoes with native and designed soybean glycinins were safe based on their almost equivalent composition to that of non-transgenic and the ready digestibility of native and designed glycinins expressed in the transgenic potatoes. However, these authors indicated that this safety was based only on the concept of "substantial equivalence."…”

Biological response of rat fed diets with high tuber content of conventionally bred and transgenic potato resistant to necrotic strain of potato virus (PVYN) Part I. Chemical composition of tubers and nutritional value of diets

“…Tests conducted so far do not show any influence of genetic modification on the chemical composition of plants. There were no differences in chemical composition between genetically modified corn (Aulrich, Bö hme, Daenicke, Halle, & Flachowsky, 2001), soybean (Taylor, Fuchs, MacDonald, Shariff, & Padgette, 1999), potatoes (Hashimoto et al, 1999a(Hashimoto et al, , 1999b and their conventional ancestor lines. This was also recorded by Rogan et al (2000), who investigated the composition of different insect-and virus-resistant potatoes.…”

Next-generation protein-rich potato expressing the seed protein gene AmA1 is a result of proteome rebalancing in transgenic tuber

“…However, these attempts were not successful because, when introduced in target plants, the transgene resulted in a dramatic increase only in methionine along with a significant decrease in cysteine (13,17). Other examples include the soybean glycinin, expression of which in potato tubers did not lead to any remarkable increase either in protein content or in amino acid concentration (40). Furthermore, plans for commercialization of these transgenic crops were abandoned because the donor proteins were allergenic (41).…”