Safety assessment of MEFAS: an innovative hybrid salt of mefloquine and artesunate for malaria treatment

Lima, Daniely Alves de; Andreotti, Carlos Eduardo Linhares; Ferreira, Fabiane Antiquera; Pauli, Karoline Bach; Silva, Gustavo Ratti da; Ribeiro, Rita de Cássia Lima; Dalsenter, Paulo Roberto; Boechat, Núbia; Gasparotto, Arquimedes; Lourenço, Emerson Luiz Botelho; Lívero, Francislaine Aparecida dos Reis

doi:10.1080/01480545.2019.1607371

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Cure disease Artemether Lumefantrine Antimalaria [ 120,121] Dihydroartemisinin Piperaquine Antimalaria [ 121] Pyropheophorbide-iron Anticancer [121] Artesunate Amodiaquine Anti-malaria; Anti-EBOV [ 122] Mefloquine Anti-malaria [ 123] Lamivudine Anti-HBV [ 112] Thymoquinone hybrids Anti-CMV [66] 8 years of using artemether-amphetamine combination therapy for simple P. falciparum malaria in Bagamoyo district, Tanzania, also showed promising results with a high and sustained cure rate. [26] Vathsala et al found ART associated with curcumin might prevent recurrence of P. falciparum malaria.…”

Section: Common Partnersmentioning

confidence: 99%

Therapeutical Utilization and Repurposing of Artemisinin and Its Derivatives: A Narrative Review

Lin

Wang

et al. 2023

Advanced Biology

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Artemisinin (ART) and its derivatives have great therapeutical utility as antimalarials and can be repurposed for other indications, such as viral infections, autoimmune diseases, and cancer. This review presents a comprehensive overview of the therapeutic effects of ART‐based drugs, beyond their antimalarial effects. This review also summarizes the information on their repurposing in other pathologies, with the hope that it will guide the future optimization of the use of ART‐based drugs and of the treatment strategies for the listed diseases. By reviewing related literature, ART extraction and structure as well as the synthesis and structure of its derivatives are presented. Subsequently, the traditional roles of ART and its derivatives against malaria are reviewed, including antimalarial mechanism and occurrence of antimalarial resistance. Finally, the potential of ART and its derivatives to be repurposed for the treatment of other diseases are summarized. The great repurposing potential of ART and its derivatives may be useful for the control of emerging diseases with corresponding pathologies, and future research should be directed toward the synthesis of more effective derivatives or better combinations.

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Section: Common Partnersmentioning

confidence: 99%

Therapeutical Utilization and Repurposing of Artemisinin and Its Derivatives: A Narrative Review

Lin

Wang

et al. 2023

Advanced Biology

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Immunoprotective Potential of Adenylosuccinate Synthetase Protein (PurA) in Streptococcus equi ssp. zooepidemicus Infections

Zhang,

Chen,

Gao

et al. 2024

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Background:: Streptococcus equi ssp. zooepidemicus (SEZ) is one important pathogen. There are still sporadic outbreaks in China, northern United States and the Netherlands. Adenylosuccinate synthetase PurA, a newly discovered protein in prior research, requires further assessment of its protective effectiveness. Methods:: In this study, we focused on the expression of recombinant PurA from SEZ ATCC 35246. We evaluated the immunoreactivity of this recombinant protein using convalescent minipig sera. Additionally, we conducted experiments in mice to assess its immunogenic properties. Results:: Our findings revealed that the recombinant PurA triggered a substantial antibody response in mice, resulting in an 80% protection rate against SEZ infection. Notably, mice immunized with PurA exhibited significantly reduced bacterial colonization in all organs compared to the PBS control group. Furthermore, the levels of IL-6, IL-8, IL-1β, and TNF-α in mouse serum were significantly elevated in the PurA-immunized group compared to the control group. Hyperimmune sera targeting PurA effectively eliminated SEZ in bactericidal tests. Remarkably, antibodies against PurA demonstrated a significant inhibitory effect on developing SEZ biofilm. Conclusion:: Immunization with PurA elicited robust humoral and cellular immune responses in mice. These promising results suggest the potential utility of PurA in developing SEZ vaccine immunogens, providing a valuable avenue for further research into SEZ infection prevention and control.

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Malaria transmission-blocking Drugs: Implications and Future Perspectives

et al. 2020

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Since the world is inching toward malaria elimination, the scientific community worldwide has begun to realize the importance of malaria transmission-blocking interventions. The onus of breaking the life cycle of the human malaria parasite Plasmodium falciparum predominantly rests upon transmission-blocking drugs because of emerging resistance to commonly used schizonticides and insecticides. This third part of our review series on malaria transmission-blocking entails transmission-blocking potential of preclinical transmission-blocking antimalarials and other non-malaria drugs/experimental compounds that are not in clinical or preclinical development for malaria but possess transmission-blocking potential. Collective analysis of the structure and the activity of these experimental compounds might pave the way toward generation of novel prototypes of next-generation transmission-blocking drugs.

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Safety assessment of MEFAS: an innovative hybrid salt of mefloquine and artesunate for malaria treatment

Cited by 3 publications

References 29 publications

Therapeutical Utilization and Repurposing of Artemisinin and Its Derivatives: A Narrative Review

Therapeutical Utilization and Repurposing of Artemisinin and Its Derivatives: A Narrative Review

Immunoprotective Potential of Adenylosuccinate Synthetase Protein (PurA) in Streptococcus equi ssp. zooepidemicus Infections

Malaria transmission-blocking Drugs: Implications and Future Perspectives

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