Safety Assessment of Monoglyceryl Monoesters as Used in Cosmetics

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 44 monoglyceryl monoesters that are structurally constituted as the esterification products of glycerin and carboxylic acids (the majority of which are fatty acids); 36 of these monoesters were previously reviewed by the Panel, and 8 are reviewed herein for the first time. Most of the monoglyceryl monoesters have several reported functions in cosmetics, but the most common function among the ingredients is skin conditioning agent; a few are reported to function only as surfactant–emulsifying agents. The Panel reviewed relevant new data, including frequency and concentration of use and considered the data from previous Cosmetic Ingredient Review reports. The Panel concluded that these ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment.

Safety Assessment of Ethers and Esters of Ascorbic Acid as Used in Cosmetics

“…The developmental and reproductive toxicity data summaries for these analogous compounds may be found in the original CIR reports. [45][46][47][48][49][50][51][52][53][54][55][56]…”

Phase Behavior of Monoglycerides in Vegetable and Mineral Oil

“…Given its amphiphilic character the MGs are the most commonly polar lipids used as surfactant agents (i.e., emulsi ers) in food products [1]. Additionally, MGs are widely used in cosmetic products, where depending on the length and unsaturation extent of the esteri ed fatty acid are used in emollients, deodorants, preservatives, and/or transdermal agents [2][3]. It is important to note that under speci c time-temperature conditions and concentration, the MGs can also develop oleogels either independently [4][5][6][7] or through molecular interaction with other molecules including water [8][9][10][11], high molecular weight polymers (i.e., ethylcellulose) or with vegetable waxes (i.e., alkyl esters) [12][13][14].…”

Amended Safety Assessment of Triglycerides as Used in Cosmetics

“…In 2015, the Panel re-evaluated the safety of Hydroxystearic Acid and Glyceryl Stearate and Glyceryl Stearate SE, reaffirming that Hydroxystearic Acid is safe as a cosmetic ingredient in the present practices of use and concluding that Glyceryl Stearate and Glyceryl Stearate SE are safe in the present practices of use and concentration. 2 (In 1982, the conclusion issued for Glyceryl Stearate and Glyceryl Stearate SE was safe for topical application to humans. 3 )…”

“…The Panel evaluated the safety of glycerin as used in cosmetics in 2014, concluding that glycerin is safe in cosmetics in the present practices of use and concentration described in the safety assessment. 8 Additionally, the Panel reviewed the safety of 44 monoglyceryl monoesters in 2015, concluding that those ingredients are safe in the present practices of use and concentration, 2 and of a group of diglycerides in 2007, concluding this family of ingredients is safe in the present practices of use and concentration provided the content of 1,2-diesters is not high enough to induce epidermal hyperplasia. 9 Many of the acid components and related glyceryl esters of these triglycerides have also been reviewed by the Panel.…”