Safety assessment of nanoparticles in food: Current status and prospective

Wang, Mengjie; Li, Shilin; Chen, Zhangjian; Zhu, Jian; Hao, Weidong; Chen, Wen; Zheng, Yu-xin; Qu, Weidong; Liu, Ying

doi:10.1016/j.nantod.2021.101169

Cited by 29 publications

(16 citation statements)

References 146 publications

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“…Experimental evidence shows that the physicochemical properties of nanoparticles are one of the key factors determining their fate in the body [1,6]. Studies have indicated that besides particle size, synthesis methods, elemental composition, surface charge and area, aggregation, and dissolution in body fluids, surface coating also affects the tissue biodistribution and cellular uptake of nanoparticles as well as their reactivity and toxicity [6,25,26]. Of the mentioned factors, surface modification has the most significant influence on the immune system and is likely to determine the toxicity of nanoparticles [27,28].…”

Section: Discussionmentioning

confidence: 99%

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

Dziendzikowska

Wilczak

Grodzicki

et al. 2022

IJMS

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Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. The level of exposure to nanosilver is constantly raising, and a growing body of research highlights that it is harmful to the health, especially the nervous system, of humans. The potential pathways through which nanosilver affects neurons include the release of silver ions and the associated induction of oxidative stress. To better understand the mechanisms underlying the neurotoxicity of nanosilver, in this study we exposed male Wistar rats to 0.5 mg/kg body weight of AgNPs coated with bovine serum albumin (BSA), polyethylene glycol (PEG), or citrate, or to AgNO3 as a source of silver ions for 28 days and assessed the expression of antioxidant defense markers in the hippocampus of the exposed animals after 1 week of spatial memory training. We also evaluated the influence of AgNPs coating on neurosteroidogenesis in the rat hippocampus. The results showed that AgNPs disrupted the antioxidant system in the hippocampus and induced oxidative stress in a coating-dependent manner, which could potentially be responsible for neurodegeneration and cognitive disorders. The analysis of the influence of AgNPs on neurosteroids also indicated coating-dependent modulation of steroid levels with a significant decrease in the concentrations of progesterone and 17α-progesterone in AgNPs(BSA), AgNPs(PEG), and Ag+ groups. Furthermore, exposure to AgNPs or Ag+ resulted in the downregulation of selected genes involved in antioxidant defense (Cat), neurosteroid synthesis (Star, Hsd3b3, Hsd17b1, and Hsd17b10), and steroid metabolism (Ar, Er1, and Er2). In conclusion, depending on the coating material used for their stabilization, AgNPs induced oxidative stress and modulated the concentrations of steroids as well as the expression of genes involved in steroid synthesis and metabolism.

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Section: Discussionmentioning

confidence: 99%

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

Dziendzikowska

Wilczak

Grodzicki

et al. 2022

IJMS

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“…These intrinsic properties are the important factors to be taken into account. Several international agencies, especially the International Standard Organization (ISO) or the French N, have elaborated guidelines or protocols for the risk evaluation in nanotechnology [152][153][154]. Characterization and identification of nanomaterials in food applications were included in the guidelines for the risk analysis of food products by the European Food Safety Authority.…”

Section: Status Of Toxicological Assessment and Characterization Of N...mentioning

confidence: 99%

Evolution and Recent Scenario of Nanotechnology in Agriculture and Food Industries

Vijayakumar¹,

Surendhar²,

Natrayan

et al. 2022

Journal of Nanomaterials

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Nanotechnology is an emerging technology in the field of food and agriculture; every individual molecule and atom can be modified or controlled by this technology. Everything that exists on the earth is made up of atoms and molecules. Problems in all the fields can easily be overcome by modifying or altering their nanosize. Similarly, nanotechnology could address many issues in the agriculture and food industries. Nanomaterials play a keen role in the place of pesticides, fertilizers, and biosensors. Nutrition enhancement, safe delivery of bioactive components and micronutrients, and food preservations were facilitated by the applications of nanotechnologies. Efforts have to be taken to create awareness among the public in this nanotechnology field. Future research directions were identified in this review to improve the nanoembedded agriculture system. This article reviews the recent development in the agriculture and food industries through nanotechnology, application of nanotechnology in the food and agricultural sectors, and research backlogs in such sectors.

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“…Oxidative stress as a mechanism of NM toxicity has been extensively reviewed (Liu et al, 2021; Wang et al, 2021; Wu & Zhu, 2020). Under normal circumstances, ROS plays a transmissive role in biological signals in the human body, helping to maintain redox balance and critical cellular functions (Sies & Jones, 2020).…”

Section: Potential Mechanisms Of Male Reproductive Toxicitymentioning

confidence: 99%

“…In modern society, nanomaterials (NMs) have been widely used in the military, medical, electronics, agriculture, cosmetics, and pharmaceutical industries, while use in other fields is expanding (Sun et al, 2021; Wang et al, 2021). NMs are characterized by their small size, large specific surface area, and physicochemical properties distinct from other materials, such as magnetic, thermal, and conductive (Liu, Bai, et al, 2020; Wang et al, 2019; Wang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The potential for nanomaterial toxicity affecting the male reproductive system

Ning

Zhang

et al. 2022

WIREs Nanomed Nanobiotechnol

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With the development of nanotechnology, nanomaterials offer great advantages in a wide variety of industrial and consumer products, and show promise for biomedical applications. However, with these new products, nanomaterial pollutants may enter the human body to cause adverse health effects, including hazards to the male reproductive system. Nanomaterials can enter the body through inhalation, oral exposure, or intravenous injection, and reach the testis via the blood, penetrate the Sertoli cell barrier, and directly or indirectly elicit toxicopathological changes to the testicles. These may then trigger hormone disorders, inhibit spermatogenic cell proliferation, and induce apoptosis, ultimately leading to a decrease in sperm motility and number, ultimately diminishing male reproductive capacity. This review will discuss the toxicological effects of nanomaterials on the male reproductive system, including inflammation, the impact on the hypothalamic–pituitary–gonadal axis (HPG axis), lipid peroxidation, and free ion release relevant to germ cells, Sertoli cell tight junctions, and the gonadal endocrine system.This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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Safety assessment of nanoparticles in food: Current status and prospective

Cited by 29 publications

References 146 publications

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids

Evolution and Recent Scenario of Nanotechnology in Agriculture and Food Industries

The potential for nanomaterial toxicity affecting the male reproductive system

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