Safety assessment of phytase transgenic maize 11TPY001 by 90-day feeding study in rats

Liang, Chunlai; Sun, Nana; Zhang, Xin; Cui, Wenming; Zhou, Yu; Jia, Xudong

doi:10.1016/j.fct.2021.112254

Cited by 6 publications

(1 citation statement)

References 38 publications

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“…Similarly, transgenic Bt plants were documented to have little impact on the soil biota, including earthworms, collembolans, and the general soil microflora 7 . Furthermore, a 90-day rodent feeding experiment showed that phytase transgenic maize did not affect the health of mice 8 . Similarly, there was no significant difference in growth performance and feeding performance in rainbow trout ( Oncorhynchus mykiss ) fed transgenic defatted soybean meal for 12 weeks 9 .…”

Section: Introductionmentioning

confidence: 99%

Safety assessment of subchronic feeding of insect-resistant and herbicide-resistant transgenic soybeans to juvenile channel catfish (Ictalurus punctatus)

Xiang

Luo

Jiang

et al. 2023

Sci Rep

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Transgenic soybean is one of the most planted crops for human food and animal feed. The channel catfish (Ictalurus punctatus) is an important aquatic organism cultured worldwide. In this study, the effect of six different soybean diets containing: two transgenic soybeans expressing different types of cp4-epsps, Vip3Aa and pat genes (DBN9004 and DBN8002), their non-transgenic parent JACK, and three conventional soybean varieties (Dongsheng3, Dongsheng7, and Dongsheng9) was investigated in juvenile channel catfish for eight weeks, and a safety assessment was performed. During the experiment, no difference in survival rate was observed in six groups. The hepatosomatic index (HSI) and condition factor (CF) showed no significant difference. Moreover, comparable feed conversion (FC), feeding rate (FR), and feed conversion ratio (FCR) were found between transgenic soybean and JACK groups. Assessment of growth performance showed that the weight gain rate (WGR) and specific growth rate (SGR) of channel catfish were consistent. In addition, there were no changes in enzyme activity indexes (lactate dehydrogenase (LDH), total antioxidant capacity (T-AOC), aspartate aminotransferase (AST) and alanine aminotransferase (ALT)) in channel catfish among treatments. The research provided an experimental basis for the aquaculture feed industry to employ transgenic soybean DBN9004 and DBN8002 for commercial purposes.

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Section: Introductionmentioning

confidence: 99%

Safety assessment of subchronic feeding of insect-resistant and herbicide-resistant transgenic soybeans to juvenile channel catfish (Ictalurus punctatus)

Xiang

Luo

Jiang

et al. 2023

Sci Rep

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Ninety‐Day Feeding Test of Stacked DBN9936 × DBN9501 Maize on Sprague Dawley Rats

Li,

Han,

Shi

et al. 2024

J of Applied Toxicology

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The transgenic maize DBN9936 × DBN9501, which confers resistance to insects and tolerance to herbicides, was developed via conventional cross breeding of transgenic maize DBN9936 and DBN9501. In our present study, a 90‐day feeding toxicity study was conducted on Sprague Dawley rats to evaluate the safety of the maize. A total of 140 rats were randomly assigned to seven groups (n = 10/sex/group): one control group, three genetically modified (GM) groups with 17.5%, 35%, and 70% (wt/wt) GM maize, respectively, and three non‐GM groups with corresponding incorporation rate of parental maize DBN318. The rats of control group were fed with AIN93G diet. The parameters including body weights, food consumption, hematology, serum biochemistry, organ weights, and histopathology were examined during the course of the study. Compared with the non‐GM group or AIN93G control group, minor statistical differences were observed for some parameters in some groups, yet none of them was considered a GM‐related adverse effect. In conclusion, the results demonstrated that no adverse effect was observed on rats following 90 days feeding with diet containing up to 70% GM maize. The results indicated that stacked maize DBN9936 × DBN9501 was as safe as its parental DBN318 maize.

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A 90-day feeding study of genetically modiﬁed maize LP007-1 in wistar han RCC rats

Zhou,

Li,

Zhao

et al. 2023

Food and Chemical Toxicology

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Safety assessment of phytase transgenic maize 11TPY001 by 90-day feeding study in rats

Cited by 6 publications

References 38 publications

Safety assessment of subchronic feeding of insect-resistant and herbicide-resistant transgenic soybeans to juvenile channel catfish (Ictalurus punctatus)

Safety assessment of subchronic feeding of insect-resistant and herbicide-resistant transgenic soybeans to juvenile channel catfish (Ictalurus punctatus)

Ninety‐Day Feeding Test of Stacked DBN9936 × DBN9501 Maize on Sprague Dawley Rats

A 90-day feeding study of genetically modiﬁed maize LP007-1 in wistar han RCC rats

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