Safety assessment of the iron nanoparticles – a substance with antianemic properties – under the oral administration to rats

Рєзніченко, Л. С.; Doroshenko, A.M.

doi:10.31073/vet_biotech37-07

Veterinary biotechnology

2020

DOI: 10.31073/vet_biotech37-07

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Safety assessment of the iron nanoparticles – a substance with antianemic properties – under the oral administration to rats

Л. С. Рєзніченко¹,

A.M. Doroshenko²

Abstract: В статті наведені результати визначення безпечності наночастинок залізасубстанції з протианемічними властивостями-за умов їх перорального введення при лікуванні модельної залізодефіцитної анемії щурів. Показано, що після 10-денного введення наночастинок заліза в дозі 12 мг/кг/добу маркерні біохімічні показники крові (концентрація загального білірубіну, креатиніну, сечовини, активність аланінамінотрансферази, лужної фосфатази і лактатдегідрогенази) дослідних тварин не перевищували межі норми. Дослідження тканин… Show more

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Cited by 2 publications

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The corrective effect of Au/Ag/Fe nanoparticles on oxidative stress in terms induced colon adenocarcinoma

Andriychuk,

Grytsyshyn,

Ivanchuk

et al. 2023

Actual Problems of Modern Medicine

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ABSTRACT. Studying biological markers of oxidative stress is crucial and relevant, as this process can trigger the transition from an organ's "normal state" to a "malignant lesion". The use of metal nanoparticles to correct oxidative stress manifestations in oncology is one of the most popular subjects of modern science and is actively being introduced into modern medicine. Practically all possible types of nanoparticles have found their use in solving different problems in oncology. Therefore, our study aimed to investigate the possibility of Au/Ag/Fe nanoparticles use for the correction of redox balance disorders of the antioxidant system under the conditions of induced colon adenocarcinoma. Materials and methods. The study was performed on 150 white male rats. Animals were kept in standard vivarium conditions. Division of experimental rats into groups: I - control intact group (40 individuals); II - experimental group (70 individuals) with N,N-dimethylhydrazine hydrochloride administration once a week for 30 weeks; ІІІ – an experimental group (40 animals) with daily intragastric administration of Au/Ag/Fe nanoparticles. Oxidative stress was assessed in colon tissue homogenate by changes in the concentrations of 8-iso-prostaglandin F2α (8-iso-PGF2α), TBC-active products, diene and triene conjugates, Schiff bases, as well as by the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and reduced glutathione. Results. Due to this research, we established that Au/Ag/Fe nanoparticles use leads to a decrease in the concentration of 8-iso-prostaglandin F2α (8-iso-PGF2α), TBC-active substances, diene, triene conjugates, Schiff bases. As a result of the above, we observed a reduction of manifestations of oxidative stress and restoration of enzymes of the antioxidant system and its biological mediators of a non-enzymatic nature. The activity of catalase, superoxide dismutase, glutathione peroxidase, and the concentration of reduced glutathione was restored to control indicators. Conclusions. Therefore, the use of Au/Ag/Fe nanoparticles leads to the restoration of the balance of redox equilibrium, improving the antioxidant system with induced adenocarcinoma of the large intestine.

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The corrective effect of Au/Ag/Fe nanoparticles on oxidative stress in terms induced colon adenocarcinoma

Andriychuk,

Grytsyshyn,

Ivanchuk

et al. 2023

Actual Problems of Modern Medicine

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Can Au/Ag/Fe nanoparticle composition restore blood cell counts in terms of DMH-induced colon adenocarcinoma?

Lisnychuk¹,

Dybkova²,

Рєзніченко³

et al. 2021

Modern Issues of Medicine and Management

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Scientific interest in nanomedicine nowadays is constantly growing, and nanomaterials have found wide application in diagnosis and treatment of various diseases. The most promising seem to be metal nanoparticles (NP). Some of them are actively studied in separate and there are favorable results considering their ability to normalize blood cell counts, but their co-work as a composite is still not well known. This opens a great perspective for studying NP as the blood homeostasis corrector, which could help in developing treatment schemes for many threatening diseases followed by the blood cell count disorders, especially malignant tumors. As colorectal cancer is third most commonly diagnosed, this study was focused on evaluation of blood cell counts changes in rats with DMH-induced colon adenocarcinoma in situ along with the assessment of Au/Ag/Fe NP composition corrective effect. Colon adenocarcinoma was induced by introducing N,N-dimethylhydrazine hydrochloride during 30 weeks. After pathohistological verification of developing colon adenocarcinoma in situ in DMH-treated rats Au/Ag/Fe NP composition was administered during 3 weeks. Introducing NP to the DMH-injured rats lead to increasing RBC and HGB and decreasing pathologically high-leveled MCV, MCH and MCHC to normal references. Assessed NP composition normalized the neutrophils rate, LMR and gave us a PLT rate particularly the same, as in the control group animals. Taking into account the previously proven biosafety of gold, silver and iron NP on their own and as a result the predicted biosafety of their composition we can consider further amplification of preclinical study on this NP composition of high significance, as it might be possibly used as following therapy of non-metastatic forms of colon cancer.

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Safety assessment of the iron nanoparticles – a substance with antianemic properties – under the oral administration to rats

Cited by 2 publications

References 13 publications

The corrective effect of Au/Ag/Fe nanoparticles on oxidative stress in terms induced colon adenocarcinoma

The corrective effect of Au/Ag/Fe nanoparticles on oxidative stress in terms induced colon adenocarcinoma

Can Au/Ag/Fe nanoparticle composition restore blood cell counts in terms of DMH-induced colon adenocarcinoma?

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