Safety Concerns of Nasal Corticosteroids Usage in Patients With Allergic Rhinitis

Almutairi, Talal; Aldayel, Abdulrahman Yousef; Aldayel, Abdulrahman S.; Alotaibi, Fahad Z; Alhussain, Hamad Abdulaziz

doi:10.7759/cureus.11651

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…In fact, adherence was 2 times more likely in Dermatophagoides pteronyssinus allergy, 2.7 times more likely in elevated total IgE and 15 times more likely in severe TNSS at first visit [49]. A higher level of education has also been described as a determinant of high adherence rate, along with female sex and age between 28 and 59 years old [45,52]. Furthermore, receiving daily reminders as SMS or app notifications on one's cell phone has a significant role in increasing adherence [46,47].…”

Section: Tools For Adherence Assessment and Factors Affecting Adheren...mentioning

confidence: 99%

“…Several tools are available to evaluate adherence to INCS, but none of them can be considered as the gold standard. To investigate the most commonly used tools in clinical practice to assess adherence to INCS in both adults and children, we selected a series of real-life studies about CRSwNP, allergic rhinitis and non-allergic rhinitis (Table 2) [43][44][45][46][47][48][49][50][51][52][53]. We considered allergic and non-allergic rhinitis as well to achieve additional insights and methodologies, since these nasal pathological conditions all share a therapeutic approach involving the use of INCS.…”

Section: Tools For Adherence Assessment and Factors Affecting Adheren...mentioning

confidence: 99%

“…However, this method requires strong and maintained patient collaboration and might not be reliable over time [54]. As an alternative option, patients can be asked to complete questionnaires [45,[47][48][49][50][51][52][53], which may include questions about administration habits and related issues, or reasons for treatment non-compliance. Among them, the Moriski questionnaire, which is a generic, self-reported, medication-taking-behavior scale initially validated for hypertension, is widely used, although not specifically developed for nasal therapy [55].…”

Section: Tools For Adherence Assessment and Factors Affecting Adheren...mentioning

confidence: 99%

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Adherence to Intranasal Steroids in Chronic Rhinosinusitis with Nasal Polyposis Prior to and during Biologic Therapy: A Neglected Matter

Norelli,

Schiappoli,

Senna

et al. 2024

JCM

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Adherence to treatment is essential in chronic rhinosinusitis with nasal polyposis (CRSwNP). Intranasal corticosteroids (INCS) are the first-line therapy, followed by systemic corticosteroids and surgery if needed. In cases of refractory disease, biologics are added to conventional treatment, making adherence to INCS crucial in assessing eligibility for these targeted therapies. The purpose of this review is to examine INCS adherence assessment and rate, before starting and during biologic therapy. We conducted a comprehensive literature review focusing on INCS adherence in CRSwNP treated with biologics, including randomized controlled trials and real-life studies. The search extended to studies on allergic and non-allergic rhinitis to provide broader insights into tools to assess the INCS adherence. The result was that adherence to INCS in CRSwNP is underexplored, with only a few studies addressing it directly. Various tools for adherence assessment have been identified, but none are universally accepted as standard. The review also highlights the complexity of factors influencing adherence rates. Effective CRSwNP management requires a paradigm shift to prioritize adherence in treatment guidelines and clinical practice. The review advocates for improved adherence assessment tools, a deeper understanding of influencing factors, and the integration of personalized medicine approaches, especially for biologic therapies.

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Section: Tools For Adherence Assessment and Factors Affecting Adheren...mentioning

confidence: 99%

Section: Tools For Adherence Assessment and Factors Affecting Adheren...mentioning

confidence: 99%

Section: Tools For Adherence Assessment and Factors Affecting Adheren...mentioning

confidence: 99%

See 1 more Smart Citation

Adherence to Intranasal Steroids in Chronic Rhinosinusitis with Nasal Polyposis Prior to and during Biologic Therapy: A Neglected Matter

Norelli,

Schiappoli,

Senna

et al. 2024

JCM

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Short-term influence of Immufen™ on mild allergic rhinitis: a randomized, double-blind, placebo-controlled study

Aryan,

Prabhakaran

et al. 2024

Front. Allergy

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IntroductionAllergic rhinitis (AR) is an IgE-mediated reaction to inhaled allergens, and is a prominent health concern affecting approximately 400 million people worldwide. A comprehensive understanding of AR's pathophysiology is imperative for developing novel therapies, especially considering its frequent co-morbidity with asthma and conjunctivitis. The escalating prevalence of AR is correlated with increased urbanization and environmental pollutants, recognized as prominent contributing factors. Dysregulation in immune networks, Th1/Th2 cytokine imbalance, activation of mast cells and eosinophils are implicated in AR progression. Classic AR symptoms include nasal congestion, nasal itching, rhinorrhea, and sneezing which significantly impact the quality of life, social interactions, and workplace productivity.MethodsThis randomized, double-blind, placebo-controlled, three-arm, three-sequence study was aimed to assess the efficacy of supplementation of a co-delivery form of turmeric extract with ashwagandha extract (CQAB) in comparison with a bioavailable curcumin (CGM) and placebo in alleviating AR symptoms and enhancing the quality of life in individuals with mild AR. Participants received either placebo, CGM, or CQAB twice/day for 28 days, and subjective measures were recorded at the baseline and at the end of study.ResultsCQAB supplementation demonstrated a significant (P < 0.05) improvement in Total Nasal Symptom Score (TNSS) compared to placebo and CGM. Furthermore, CQAB administration resulted in enhanced sleep quality (P < 0.05) as evaluated by the BIS questionnaire, heightened energy levels, and decreased fatigue and overall mood disturbance (POMS-SF) compared to both placebo and CGM.ConclusionThe results suggests that CQAB has the potential to be used as a dietary supplement in alleviating AR discomforts.Clinical Trial Registrationhttps://ctri.nic.in/Clinicaltrials/login.php; Identifier CTRI/2021/01/030355.

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Knowledge of, Attitudes towards, and Practices of Intranasal Corticosteroids Usage among the Allergic Rhinitis Patients of Northern Saudi Arabia: A Cross-Sectional Study

Alrasheedi

2023

Healthcare

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Intranasal corticosteroids (INCS) are generally safe and effective treatments for allergic rhinitis (AR). The improper use of INCS may not alleviate AR symptoms, and it could lead to complications and an impaired quality of life. We evaluated the knowledge of, attitudes towards, and practices of INCS usage and associated factors among AR patients using a pretested Arabic questionnaire. Of the 400 participating AR patients, 39.3%, 29.0%, and 36.5% had poor scores for knowledge, attitude, and practice, respectively. We found a significant association between knowledge and education (p< 0.001) and follow-up facilities (p = 0.036). The attitude category was significantly associated with age (p = 0.003), marital status (p = 0.004), and type of allergic patients (p< 0.001), and the practice category was significantly associated with education (p = 0.027), type of allergic patients (p = 0.008), and follow-up facilities (p = 0.030). Smoking status was significantly associated with all three categories. Furthermore, we found a positive correlation between knowledge and practice scores (Spearman’s rho of 0.451, p< 0.001). We recommend improving AR patients’ knowledge of the proper practices of INCS through health education programs. Furthermore, we recommend an exploratory mixed-method survey on the INCS usage among AR patients that involves other provinces in the KSA.

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Safety Concerns of Nasal Corticosteroids Usage in Patients With Allergic Rhinitis

Cited by 3 publications

References 26 publications

Adherence to Intranasal Steroids in Chronic Rhinosinusitis with Nasal Polyposis Prior to and during Biologic Therapy: A Neglected Matter

Adherence to Intranasal Steroids in Chronic Rhinosinusitis with Nasal Polyposis Prior to and during Biologic Therapy: A Neglected Matter

Short-term influence of Immufen™ on mild allergic rhinitis: a randomized, double-blind, placebo-controlled study

Knowledge of, Attitudes towards, and Practices of Intranasal Corticosteroids Usage among the Allergic Rhinitis Patients of Northern Saudi Arabia: A Cross-Sectional Study

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