Safety, efficacy, and immunogenicity of COVID-19 vaccines; a systematic review

Asghar, Neelam; Mumtaz, Hassan; Ahad, Syed Abdul; Eqbal, Farea; Maharjan, Reeju; Bamboria, Aditya; Shrehta, Manish

doi:10.1080/25785826.2022.2068331

Cited by 23 publications

(17 citation statements)

References 33 publications

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“…Since 2020 [16] , around 11 billion doses of vaccines have been administered all over the world. Thus far, there has been an important body of literature that has proven short- to medium-term safety profiles and efficacy [5] of these vaccines in preventing COVID-19 infection, hospitalisation and deaths(Ssentongo et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis

Zaçe

Gatta

Petrella

et al. 2022

Vaccine

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Section: Introductionmentioning

confidence: 99%

The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis

Zaçe

Gatta

Petrella

et al. 2022

Vaccine

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“…However, since they are employed in healthy people, possible adverse effects are of great clinical interest ( 107 ). Vaccination campaigns against COVID-19 began more than 1 year ago, and the efficacy of COVID-19 vaccines at 5 months or longer after being fully vaccinated is now about 90% (95% CI, 87–92%) ( 8 , 108 , 109 ). Despite the increasing effectiveness evidence, the occurrence of adverse reactions after vaccines administration may elicit some concern, especially due to the spread misinformation about COVID-19 vaccination, such as infertility in men, which are not substantiated by the data available ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…The overall safety and efficacy of the available COVID-19 vaccines have been confirmed in multiple studies and metanalyses ( 8 ), even if the occurrence of a few cases of post-vaccination complications have been observed ( 9 ), including endocrine manifestations.…”

Section: Introductionmentioning

confidence: 94%

“…Of the 64 patients, 50 (78.1%) received an mRNA vaccine (Pfizer/BioNTech BNT162b2 or Moderna mRNA-1273), 13 (20.3%) received a viral vector vaccine (Vaxzevria ChAdOx1 or Convidecia AD5-nCOV or Jennsen), and only one (1.6%) received an inactivated virus vaccine (Sinovac Biotech CoronaVac). Median time between the vaccine shot (any type) and the symptoms' development was 10 days (4)(5)(6)(7)(8)(9)(10)(11)(18)(19)(20)(21)(22)(23). Concerning the relationship between the dose of vaccine and Graves' disease onset, 35 patients (54.7%) became symptomatic after the first dose, in 27 (42.2%) after the second dose, and in one case after the third dose.…”

Section: Graves' Diseasementioning

confidence: 99%

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Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature

et al. 2022

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PurposeThe purpose of this study was to describe the current knowledge on the potential endocrine adverse effects post-COVID-19 vaccines.MethodsA PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies, and reviews written in English and published online up to 31 July 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review.ResultsThe available data showed that endocrine side effects are generally rare and with favorable outcome, being thyroid disorders the most common. Conversely, data on type 1 diabetes mellitus are rare; adrenal and pituitary events are even anecdotal. Finally, the available clinical studies suggest no impact on female reproductive system and on male and couple fertility.ConclusionOverall, these data show that, after 2 years of COVID-19 vaccines, the endocrine system is not heavily threatened.

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“…Authorized vaccines in Spain with mRNA technology (Pfizer-BioNTech and Moderna) have been shown to be highly effective against symptomatic COVID-19 infections. Moreover, the efficacy of full vaccination with two doses is estimated at 94% [ 5 ]. Some of the side effects of these vaccines may include: pain, redness, swelling, tiredness, headache, fever or nausea.…”

Section: Introductionmentioning

confidence: 99%

Association between RNAm-Based COVID-19 Vaccines and Permanency of Menstrual Cycle Alterations in Spanish Women: A Cross-Sectional Study

Mínguez-Esteban

García-Ginés

Romero‐Morales

et al. 2022

Biology

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Introduction: The purpose of this study was to delve more deeply into the medium and long-term relation between mRNA-based vaccines and changes in menstrual pain, cycle length, and amount of bleeding in Spanish women. Material and Methods: A total of 746 women (63% between 18–30 and 37% between 31–45 years old) participated in the study. A numerical rating scale was used for recording pain intensity, a pictorial chart for menstrual bleeding, and data from menstrual cycle duration, type of vaccine, number of doses and time from vaccination. Results: Sixty-five per cent of the women perceived changes in their menstrual cycle after receiving the vaccines, irrespective of type of vaccine or number of doses; all p values were > 0.05. Most of them (n = 316 out of 484) reported more than one alteration in their menstrual cycle. Almost half of the participants had been vaccinated over 5 months (45%), 3–4 months (15%) 2–3 months (26%), and one month or less (13%) before. The percentage of women that reported alterations remained strongly constant across time, p > 0.05, ranging from 64 to 65%. Conclusions: Reported alterations in Spanish women after COVID vaccination remained more than 5 months after the last dose.

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Safety, efficacy, and immunogenicity of COVID-19 vaccines; a systematic review

Cited by 23 publications

References 33 publications

The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis

The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis

Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature

Association between RNAm-Based COVID-19 Vaccines and Permanency of Menstrual Cycle Alterations in Spanish Women: A Cross-Sectional Study

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