Safety, efficacy and predictors of local recurrence after percutaneous radiofrequency ablation of biopsy-proven renal cell carcinoma

Su, Michael; Memon, Fatima; Lau, Howard; Brooks, Andrew J.; Patel, Manish I.; Woo, Henry H.; Bariol, Simon V.; Vladica, Philip

doi:10.1007/s11255-016-1355-3

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Graphical depiction of hazard ratios for cancer recurrence after LTA in previous institutional studies ( Figure 3) showed an almost 5-fold increase in recurrence rates after LTA for either TS>30 4,5,8 or TS≥30mm 6,9 .…”

Section: Graphical Depiction Of Hazard Ratios Of Previous Studiesmentioning

confidence: 81%

“…The PS-matched cohorts (LTA for TS≤30 mm versus TS>30 mm) were balanced according to age at diagnosis, gender, ethnicity, socioeconomic status, population density, period of treatment, histology and Fuhrman grade. Lastly, we generated a graphical depiction of HRs reported within previous institutional retrospective studies [4][5][6]8,9 , focused on recurrence-free survival (RFS) in LTA treated patients for TS≤30mm vs TS>30mm 4,5,8 and TS<30mm vs TS≥30mm 6,9 .…”

Section: Statistical Analysesmentioning

confidence: 99%

“…However, these data originate from institutional retrospective series [4][5][6][7][8][9] with small sample sizes (range from 62 7 to 168 patients 8 ), where oncological outcomes were mostly evaluated as recurrence free survival (RFS). Moreover, some of these studies 5,6 also included T1b renal cell carcinoma (RCC).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Tumor Size on Cancer-Specific Mortality Rate After Local Tumor Ablation in T1a Renal-Cell Carcinoma

Palumbo

Cyr

Mazzone

et al. 2019

Journal of Endourology

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Section: Graphical Depiction Of Hazard Ratios Of Previous Studiesmentioning

confidence: 81%

Section: Statistical Analysesmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Tumor Size on Cancer-Specific Mortality Rate After Local Tumor Ablation in T1a Renal-Cell Carcinoma

Palumbo

Cyr

Mazzone

et al. 2019

Journal of Endourology

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“…These therapies may be offered to older patients with comorbidities who have limited life expectancy 10 . An Australian single‐centre retrospective study of 168 patients managed with percutaneous radiofrequency ablation reported 98% and 87% disease‐free survival for 3 and 5 years respectively 32 . A European retrospective study of 808 patients managed with laparoscopic‐assisted cryoablation at eight separate centres reported 90% and 80% disease‐free survival for 5 and 10 years respectively 33 …”

Section: Current Standard Of Carementioning

confidence: 99%

Optimising assessment of kidney function when managing localised renal masses

Ellis

Joshi

et al. 2017

Medical Journal of Australia

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Increased early and incidental detection, improved surgical techniques and technological advancement mean that the management of renal mass lesions is constantly evolving. The treatment of choice for renal mass lesions has historically been radical nephrectomy. Partial nephrectomy is now recommended for localised renal masses, owing to favourable renal functional outcomes. Ablative renal surgery confers a significant risk of chronic kidney disease. There are few studies assessing long term outcomes of nephrectomy on renal outcomes, and virtually no studies assessing long term outcomes for less invasive therapies such as ablation. Unless a renal mass is clearly benign on imaging, management decisions will be made with an assumption of malignancy. The content of this review applies to both benign and malignant renal mass lesions. We advocate for improved strategies for kidney function assessment and risk stratification, early targeted referral, and regular screening for chronic kidney disease for all patients after surgery.

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“…One of the most important limitations of RFA is represented by the loss of heat occurring close to vessels due to the blood flow (heat sink effect). However, heat propagation from the tip of the electrode might determine injury to close sensitive structures [37, 38]. …”

Section: Introductionmentioning

confidence: 99%

Tips and tricks for a safe and effective image-guided percutaneous renal tumour ablation

et al. 2017

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Image-guide thermal ablations are nowadays increasingly used to provide a minimally invasive treatment to patients with renal tumours, with reported good clinical results and low complications rate. Different ablative techniques can be applied, each with some advantages and disadvantages according to the clinical situation. Moreover, percutaneous ablation of renal tumours might be complex in cases where there is limited access for image guidance or a close proximity to critical structures, which can be unintentionally injured during treatment. In the present paper we offer an overview of the most commonly used ablative techniques and of the most important manoeuvres that can be applied to enhance the safety and effectiveness of percutaneous image-guided renal ablation. Emphasis is given to the different technical aspects of cryoablation, radiofrequency ablation, and microwave ablation, on the ideal operating room setting, optimal image guidance, application of fusion imaging and virtual navigation, and contrast enhanced ultrasound in the guidance and monitoring of the procedure. Moreover, a series of protective manoeuvre that can be used to avoid damage to surrounding sensitive structures is presented. A selection of cases of image-guided thermal ablation of renal tumours in which the discussed technique were used is presented and illustrated.Teaching points• Cryoablation, radiofrequency and microwave ablation have different advantages and disadvantages. • US, CT, fusion imaging, and CEUS increase an effective image-guidance. • Different patient positioning and external compression may increase procedure feasibility. • Hydrodissection and gas insufflation are useful to displace surrounding critical structures. • Cold pyeloperfusion can reduce the thermal damage to the collecting system.

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Safety, efficacy and predictors of local recurrence after percutaneous radiofrequency ablation of biopsy-proven renal cell carcinoma

Abstract: Radiofrequency ablation performed at our centre was a safe and effective procedure with low complication rates and durable RFS. Tumour characteristics, comorbidities and learning curve were not associated with local recurrence.

Cited by 6 publications

References 34 publications

Impact of Tumor Size on Cancer-Specific Mortality Rate After Local Tumor Ablation in T1a Renal-Cell Carcinoma

Impact of Tumor Size on Cancer-Specific Mortality Rate After Local Tumor Ablation in T1a Renal-Cell Carcinoma

Optimising assessment of kidney function when managing localised renal masses

Tips and tricks for a safe and effective image-guided percutaneous renal tumour ablation

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