Safety evaluation of chitosan and chitosan acid salts from Panurilus argus lobster

Lagarto, Alicia; Merino, Nelsón; Valdés, Odalys; Dominguez, Jesus H.; Spencer, Evelyn; Paz, Nilia de la; Aparicio, Guillermo

doi:10.1016/j.ijbiomac.2014.10.030

Cited by 13 publications

(7 citation statements)

References 22 publications

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“…It is of commercial interest due to its biodegradability, biocompatibility, nontoxicity, antimicrobial activity and adhesive properties. 31 A comparison was drawn between the regrown biomimetic layer formed by chitosan only, chitosan-LRAP, and chitosan-rP172 (full-length amelogenin) hydrogels at the end of 3 days of remineralization. Smaller, scattered crystallites were observed in patches over the demineralized enamel window in the chitosanonly group (seen in SEM) whereas in the presence of LRAP-CS, larger and denser organized crystals were seen similar in morphology to the crystals grown under the influence of full-length amelogenin chitosan hydrogel.…”

Section: B the Mechanism Of Chitosan-lrap In Promoting Regrowth Of Ementioning

confidence: 99%

Repairing human tooth enamel with leucine-rich amelogenin peptide–chitosan hydrogel

et al. 2016

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We have recently reported the repair of carious enamel using a full-length amelogeninchitosan hydrogel through guided stabilization and growth of mineral clusters. The objective of this study was to further evaluate the enamel repair potential of smaller amelogenin peptides like LRAP (leucine-rich amelogenin peptide) and compare their efficiency with their full-length counterpart. The demineralized tooth slices treated with a single application of LRAP-chitosan hydrogel for 3 days showed a dense mineralized layer consisting of highly organized enamel-like apatite crystals. Focus-ion beam technique showed a seamless growth at the interface between the repaired layer and native enamel. There was a marked improvement in the surface hardness after treatment of the demineralized sample with almost 87% recovery of the hardness value to that of sound enamel sections. This current approach can inspire the design of smaller peptide analogues based on naturally occurring amelogenin as a competent, low-cost, and safe strategy for enamel biomimetics to curb the high prevalence of incipient dental caries.

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Section: B the Mechanism Of Chitosan-lrap In Promoting Regrowth Of Ementioning

confidence: 99%

Repairing human tooth enamel with leucine-rich amelogenin peptide–chitosan hydrogel

et al. 2016

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“…This was indicated by a study investigating the single- and repeated-dose toxicity of chitosan and its salts (lactate and acetate) on rats. At oral doses of 2000 mg/kg, no fatalities or changes in the general behavior of the rats in both the acute- and repeated-dose toxicity studies were observed (Lagarto et al 2015). This led us to a conclusion that chitosan obtained from lobster shells may be safe for use in the pharmaceutical industry.…”

Section: Various Applications Of Extracts Derived From Lpbsmentioning

confidence: 99%

Lobster processing by-products as valuable bioresource of marine functional ingredients, nutraceuticals, and pharmaceuticals

Nguyễn

Barber

Corbin

et al. 2017

Bioresour. Bioprocess.

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The worldwide annual production of lobster was 165,367 tons valued over $3.32 billion in 2004, but this figure rose up to 304,000 tons in 2012. Over half the volume of the worldwide lobster production has been processed to meet the rising global demand in diversified lobster products. Lobster processing generates a large amount of by-products (heads, shells, livers, and eggs) which account for 50–70% of the starting material. Continued production of these lobster processing by-products (LPBs) without corresponding process development for efficient utilization has led to disposal issues associated with costs and pollutions. This review presents the promising opportunities to maximize the utilization of LPBs by economic recovery of their valuable components to produce high value-added products. More than 50,000 tons of LPBs are globally generated, which costs lobster processing companies upward of about $7.5 million/year for disposal. This not only presents financial and environmental burdens to the lobster processors but also wastes a valuable bioresource. LPBs are rich in a range of high-value compounds such as proteins, chitin, lipids, minerals, and pigments. Extracts recovered from LPBs have been demonstrated to possess several functionalities and bioactivities, which are useful for numerous applications in water treatment, agriculture, food, nutraceutical, pharmaceutical products, and biomedicine. Although LPBs have been studied for recovery of valuable components, utilization of these materials for the large-scale production is still very limited. Extraction of lobster components using microwave, ultrasonic, and supercritical fluid extraction were found to be promising techniques that could be used for large-scale production. LPBs are rich in high-value compounds that are currently being underutilized. These compounds can be extracted for being used as functional ingredients, nutraceuticals, and pharmaceuticals in a wide range of commercial applications. The efficient utilization of LPBs would not only generate significant economic benefits but also reduce the problems of waste management associated with the lobster industry. This comprehensive review highlights the availability of the global LPBs, the key components in LPBs and their current applications, the limitations to the extraction techniques used, and the suggested emerging techniques which may be promising on an industrial scale for the maximized utilization of LPBs. Graphical abstractLobster processing by-product as bioresource of several functional and bioactive compounds used in various value-added products

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“…However, chitosan from shrimp and crabs is seasonal, allergenic and regional. Moreover, with the increase of marine pollution in recent years, chitosan from shrimp and crabs may pose some hazards to the health of patients [9,10]. Therefore, it is of utmost importance to develop alternative sources for the production of chitosan.…”

Section: Introductionmentioning

confidence: 99%

Preparation, physicochemical and pharmaceutical characterization of chitosan from Catharsius molossus residue

Xin

Tan

2015

International Journal of Biological Macromolecules

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Safety evaluation of chitosan and chitosan acid salts from Panurilus argus lobster

Cited by 13 publications

References 22 publications

Repairing human tooth enamel with leucine-rich amelogenin peptide–chitosan hydrogel

Repairing human tooth enamel with leucine-rich amelogenin peptide–chitosan hydrogel

Lobster processing by-products as valuable bioresource of marine functional ingredients, nutraceuticals, and pharmaceuticals

Preparation, physicochemical and pharmaceutical characterization of chitosan from Catharsius molossus residue

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