Safety evaluation of long term oral treatment of methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats

Goyal, Surbhi; Manivannan, B.; Ansari, Abdul S.; Jain, Sreepat; Lohiya, N. K.

doi:10.1016/j.jep.2009.11.007

Cited by 24 publications

(12 citation statements)

References 12 publications

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“…Therefore, the histological changes of testis were more pronounced, where the exposure periods coincides with the stages of testicular configuration. On the other hand, the negative effect of papaya seeds on the histological structure of testes was also observed in laboratory animals, such as rats (Goyal et al, 2010) and rabbits (Lohiya et al, 1999). Also, other medical herbs caused the same changes in the testis and ovaries of Nile tilapia such as Aloe vera latex (Jegede, 2009) and Hibiscus rosa-sinensis leaf (Jegede, 2010).…”

Section: Disscusionmentioning

confidence: 96%

Assessment Study on the use of Pawpaw; Carica papaya Seeds to Control Oreochromis niloticus Breeding

Abbas¹,

Abbas²

2011

Pakistan J. of Biological Sciences

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This study was carried out to assess the ability of using pawpaw (Carica papaya) seeds as a natural reproduction inhibitor for tilapia fish (Oreochromis niloticus) culture to control its breeding. Biochemical, physiological and histopathological effects ofpawpaw seeds on male tilapia fish were also determined. Mature male tilapia were stocked for 4 weeks and treated with low dose (3 g/kg/day) and high dose (6 g/kg/day) of ground dried pawpaw seeds mixed with their feed. The obtained results showed that the pawpaw seeds induced permanent sterility in the high dose treated fish while the low dose treatment showed reversible results. The results also demonstrated that fish treated with high dose of pawpaw exhibited higher biochemical and physiological effects as: low meat quality, a progressive fall in erythrocyte (RBCs) count, hemoglobin (Hb) content and haematocrit values. Also the high dose revealed a significant increase in the leukocytes (WBCs) count, serum glucose, total protein, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine and uric acid levels. Moreover, serum total lipids revealed a significant decrease compared to control group. On the other hand, the low dose treatment revealed lower biochemical and physiological changes. Histological sections of testis showed disintegration of sperm cells and focal necrosis of seminefrous tubules in the high dose treated fish, hepato-pancreas and posterior kidney tissues also showed severe changes in high dose treated fish. Milder degenerative changes in some necrotic foci and slight changes in hepato-pancreas and posterior kidney were observed in the low dose treated fish. The study concluded that pawpaw seeds which are cheap and easy to obtain, can be incorporated into fish feeds with adjusted amount and be used to control breeding of tilapia fish in growing ponds instead of unfavorable and expensive hormonal use.

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Section: Disscusionmentioning

confidence: 96%

Assessment Study on the use of Pawpaw; Carica papaya Seeds to Control Oreochromis niloticus Breeding

Abbas¹,

Abbas²

2011

Pakistan J. of Biological Sciences

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“…Traditionally, different parts of the papaya plant are used in the treatment of various ailments such as asthma, ulcers, eczema, diabetes, helminth infections and fever (Nguyen et al 2013). Research also demonstrated its beneficial traditional role in wound healing, and in the treatment of cardiovascular diseases, dengue fever, cancer, malaria, hypoglycemia, hyperlipidemia, fungal diseases and as a male contraceptive (Gupta et al 1990;Nayak et al 2007;Goyal et al 2010;Otsuki et al 2010;Iyer et al 2011;Pedro et al 2011;Kovendan et al 2012;Yasmeen & Prabhu 2012;Nunes et al 2013). Papaya extracts have also been reported to have significant anti-inflammatory activity (Owoyele et al 2008;Lee et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey

Cabot

Shaw

et al. 2016

Journal of Immunotoxicology

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Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords ''papaya'', ''anti-inflammatory and inflammation'' and ''immunomodulation and immune'' along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the antiinflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking. ARTICLE HISTORY

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“…Various tissues, namely testis, cauda epididymis, seminal vesicle and ventral prostate, were excised and were fixed in Bouin's solution. Tissue sections (5 μm) were obtained following the method described earlier . The sections were stained with Harris' hematoxylin and eosin for histopathological observations.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Efficacy and Safety of Recombinant Sperm‐Specific Contraceptive Vaccine in Albino Mice

Goyal

Manivannan

Kumraj

et al. 2013

American J Rep Immunol

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Safety evaluation of long term oral treatment of methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats

Cited by 24 publications

References 12 publications

Assessment Study on the use of Pawpaw; Carica papaya Seeds to Control Oreochromis niloticus Breeding

Assessment Study on the use of Pawpaw; Carica papaya Seeds to Control Oreochromis niloticus Breeding

Anti-inflammatory and immunomodulatory properties of Carica papaya

Evaluation of Efficacy and Safety of Recombinant Sperm‐Specific Contraceptive Vaccine in Albino Mice

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