Safety evaluation of Nostoc flagelliforme (nostocales, cyanophyceae) as a potential food

Takenaka, Hiroyuki; Yamaguchi, Yuji; Sakaki, S; Watarai, K; Тanaka, Noriyuki; Hori, Masaki; Seki, Hitomi; Tsuchida, Masako; Yamada, Ayaka; Nishimori, Toshikazu; Morinaga, Tagahiko

doi:10.1016/s0278-6915(98)00089-1

Cited by 43 publications

(22 citation statements)

References 11 publications

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“…On the island of Java, colonies of Nostoc commune are eaten (Zaneveld, 1959) and in China, were consumed as early as the 3rd century A.D. (Gao, 1998;Takenaka et al, 1998;Potts, 2000). Called by the Chinese "Ge-Xian-Mi", Nostoc commune grows as small spheres in mountain rice paddies during winter and is sold at USD $70-120 per kg dry weight as an additive to soups or a main course to be fried with meat, particularly duck (Qui et al, 2002).…”

Section: Consumption Of Nostoc By Indigenous Peoplesmentioning

confidence: 99%

Cyanobacteria (Nostoc commune) used as a dietary item in the Peruvian highlands produce the neurotoxic amino acid BMAA

Johnson

King

Banack

et al. 2008

Journal of Ethnopharmacology

117

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Section: Consumption Of Nostoc By Indigenous Peoplesmentioning

confidence: 99%

Cyanobacteria (Nostoc commune) used as a dietary item in the Peruvian highlands produce the neurotoxic amino acid BMAA

Johnson

King

Banack

et al. 2008

Journal of Ethnopharmacology

117

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“…sphaeroids Kützing (NO), of which SP is the most commonly commercialized and consumed species. [11][12][13][14][15] BGA have been recognized as a natural product with significant pharmaceutical potential, such as anticancer, antibacterial, antiviral, antiallergic, antioxidant, anti-inflammation, and enzyme inhibiting activities. [16][17][18] We previously reported that 5% NO supplementation significantly lowered plasma TC and TG levels in C57BL/6J mice with a concomitant increase in the expression of hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR), the ratelimiting enzyme for cholesterol biosynthesis.…”

Section: Introduction Dmentioning

confidence: 99%

Hypolipidemic Effect of a Blue-Green Alga (Nostoc commune) Is Attributed to Its Nonlipid Fraction by Decreasing Intestinal Cholesterol Absorption in C57BL/6J Mice

Kim

Pham

et al. 2015

Journal of Medicinal Food

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We previously demonstrated that Nostoc commune var. sphaeroids Kützing (NO), a blue-green alga (BGA), exerts a hypolipidemic effect in vivo and its lipid extract regulates the expression of genes involved in cholesterol and lipid metabolism in vitro. The objective of this study was to investigate whether the hypolipidemic effect of NO is attributed to an algal lipid or a delipidated fraction in vivo compared with Spirulina platensis (SP). Male C57BL/6J mice were fed an AIN-93M diet containing 2.5% or 5% of BGA (w/w) or a lipid extract equivalent to 5% of BGA for 4 weeks to measure plasma and liver lipids, hepatic gene expression, intestinal cholesterol absorption, and fecal sterol excretion. Plasma total cholesterol (TC) was significantly lower in 2.5% and 5% NO-fed groups, while plasma triglyceride (TG) levels were decreased in the 5% NO group compared with controls. However, neither NO organic extract (NOE) nor SP-fed groups altered plasma lipids. Hepatic mRNA levels of sterol regulatory element-binding protein 2, 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR), carnitine palmitoyltransferase-1a, and acyl-CoA oxidase 1 were induced in 5% NO-fed mice, while there were no significant changes in hepatic lipogenic gene expression between groups. NO, but not NOE and SP groups, significantly decreased intestinal cholesterol absorption. When HepG2 cells and primary mouse hepatocytes were incubated with NOE and SP organic extract (SPE), there were marked decreases in protein levels of HMGR, low-density lipoprotein receptor, and fatty acid synthase. In conclusion, the nonlipid fraction of NO exerts TC and TG-lowering effects primarily by inhibiting intestinal cholesterol absorption and by increasing hepatic fatty acid oxidation, respectively.

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“…Todos os testes, incluindo os estudos em seres humanos, não revelaram qualquer evidência que restrinja a utilização de proteínas provenientes de cianobactérias devidamente processadas (CHAMORRO, 1980). Por isso, alguns estudos demonstraram que cianobactérias como Spirulina e Nostoc têm sido usadas como fontes de proteínas e vitaminas na alimentação humana e animal (CIFERRI, 1983;KAY & BARTON, 1991 Review / Resenha 1998;TAKENAKA et al, 1998). As cianobactérias constituem uma fonte alternativa de proteínas, fato já estudado em condições experimentais e industriais; trata-se de uma fonte proteica de custos mais reduzidos do que a proteína de origem animal.…”

Section: Proteínas E Aminoácidosunclassified

Cianobactérias: uma revisão sobre potencial nutricional e alguns aspectos biotecnológicos

Oliveira

Campos-Galvão

et al. 2013

BBR

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SUMMARYCyanobacteria are used in human nutrition since ancient times, with very high biotechnological, therapeutical and nutrition potential. The aim of this article was to review the main nutritional aspects related to the cyanobacteria that justify its introduction in food. The studies analyzed dealt especially with the cyanobacterium Spirulina and highlighted the high content of assential amino acids and lipids, vitamins and minerals, and antioxidants. It is concluded that the cyanobacterial represent an excellent nutritional supplement and a potential source for use in the prevention and treatment of various diseases. It is suggested that more microalgae should be surveyed in order to expand the knowledge and application possibilities. Keywords

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Safety evaluation of Nostoc flagelliforme (nostocales, cyanophyceae) as a potential food

Cited by 43 publications

References 11 publications

Cyanobacteria (Nostoc commune) used as a dietary item in the Peruvian highlands produce the neurotoxic amino acid BMAA

Cyanobacteria (Nostoc commune) used as a dietary item in the Peruvian highlands produce the neurotoxic amino acid BMAA

Hypolipidemic Effect of a Blue-Green Alga (Nostoc commune) Is Attributed to Its Nonlipid Fraction by Decreasing Intestinal Cholesterol Absorption in C57BL/6J Mice

Cianobactérias: uma revisão sobre potencial nutricional e alguns aspectos biotecnológicos

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