Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use

Jang, Hyun‐Jun; Shin, Chan Young; Kim, Kyu‐Bong

doi:10.5487/tr.2015.31.2.105

Cited by 145 publications

(97 citation statements)

References 11 publications

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“…Other common ingredients such as glycerine, xylitol, sorbitol, starch hydrolysates and propylene or butylene glycols seem not to bear any major lubricating or SCF adapting properties. Polyethylene glycol (PEG)-hydrogenated castor oils are more frequently used as solubilizers, and to our knowledge, do not have lubricating properties [39]. Some saliva substitutes only increase viscosity instead of lubrication, while those terms are not exchangeable [13,40].…”

Section: Discussionmentioning

confidence: 99%

Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication

et al. 2020

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Objectives The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF). Materials and methods Quartz crystal microbalance with dissipation was used to study the capability of saliva substitutes to interact with natural SCF and the ability to change the secondary SCF (S-SCF). A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and relief period expected from these substitutes under set circumstances. Results Saliva Orthana spray, Biotène spray and Gum Hydral gel had an immediate effect on a SCF, increasing its structural softness. BioXtra gel, Biotène gel, Gum Hydral gel and Glandosane spray changed the S-SCF by increasing salivary protein adsorption, while others showed no sign of interaction. With respect to relief, only 2 out of the 16 saliva substitutes tested (Saliva Orthana spray and Gum Hydral gel) performed better than water. Overall, relief period correlated positively to structural softness change, whereas a positive correlation was seen between relief and mass adsorption. Conclusions The majority of saliva substitutes did not adsorb on the SCF, thus did not enhance lubrication. Only saliva substitutes containing carrageenan, carboxymethylcellulose, pig gastric mucin, xanthan gum and carbomer performed better in enhancing oral lubrication. Clinical relevance This objective assessment will help clinicians and patients make better choice of saliva substitutes. This study provides a scientific basis for future improvement in saliva substitutes.

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Section: Discussionmentioning

confidence: 99%

Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication

et al. 2020

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“…The results also revealed the mildness of polyoxyethylene sorbitan esters independently of their alkyl chain length [62]. Frequently, the cleansing and leave-on products contain up to 20% and 5% PEG-20 glyceryl triisostearate, respectively [61]. Considering the results obtained in this work, we are convinced that the exacerbated systemic effects observed in mice treated with ME-based formulations are related to the enhanced IMQ transdermal absorption and not to the in vivo toxicity of ME-based formulation per se.…”

Section: In Vivo Antipsoriatic Activitymentioning

confidence: 84%

“…In this study, we treated mice with ME-based formulations containing approximately 40% (w/w) of PEG-20 glyceryl triisostearate. This compound is considered safe for cosmetic use, being favorably used as a penetration enhancer [61]. Surfactants have effects on the permeability of several biological membranes including skin mainly due to their potential to solubilize lipids within the stratum corneum.…”

Section: In Vivo Antipsoriatic Activitymentioning

confidence: 99%

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

et al. 2020

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Human neutrophil elastase (HNE) is a serine protease that degrades matrix proteins. An excess of HNE may trigger several pathological conditions, such as psoriasis. In this work, we aimed to synthesize, characterize and formulate new HNE inhibitors with a 4-oxo-β-lactam scaffold with less toxicity, as well as therapeutic index in a psoriasis context. HNE inhibitors with 4-oxo-β-lactam scaffolds were synthesized and characterized by NMR, FTIR, melting point, mass spectrometry and elemental analysis. In vitro cytotoxicity and serine protease assays were performed. The compound with the highest cell viability (AAN-16) was selected to be incorporated in an emulsion (AAN-16 E) and in a microemulsion (AAN-16 ME). Formulations were characterized in terms of organoleptic properties, pH, rheology, droplet size distribution, in vitro drug release and in vivo psoriatic activity. All compounds were successfully synthesized according to analytical methodology, with good yields. Both formulations presented suitable physicochemical properties. AAN-16 E presented the most promising therapeutic effects in a murine model of psoriasis. Overall, new HNE inhibitors were synthesized with high and selective activity and incorporated into topical emulsions with potential to treat psoriasis.

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“…PEGylation is typical example involving polyethylene glycol (PEG) [17] that is fully biocompatible polymer from the group of polyethers [18]. PEG is commonly used in medicine, pharmaceutics, and cosmetics [19]. Thus combination of nisin as antibacterial agent and PEG as compatible stabilizer can be suitable for most of the applications introduced above.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Thermal Stabilization of Bacteriocin Nisin Derived from Whey for Antimicrobial Modifications of Polymers

Holčapková

Rašková

Hrabalíková

et al. 2017

International Journal of Polymer Science

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This work describes novel alternative for extraction of bacteriocin nisin from a whey fermentation media and its stabilization by using polyethylene glycol as matrix with high practical applicability. This product was compared with commercially available nisin product stabilized by sodium chloride and nisin extracted and stabilized by using ammonium sulfate and polysorbate 80.The stability of samples was tested by means of long-term storage at −18, 4, 25, and 55 ∘ C up to 165 days. The nisin content in the samples was determined by high-performance liquid chromatography and electrophoresis. In addition, effect of whey fortification with lactose on nisin production and antibacterial activity studied against Staphylococcus aureus was tested. Results show that stabilization by polyethylene glycol provides enhanced nisin activity at 55 ∘ C after 14 days and long-term stability at 25 ∘ C with keeping antibacterial activity.

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Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use

Cited by 145 publications

References 11 publications

Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication

Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication

Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management

Isolation and Thermal Stabilization of Bacteriocin Nisin Derived from Whey for Antimicrobial Modifications of Polymers

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