Safety evaluation of Se-methylselenocysteine as nutritional selenium supplement: Acute toxicity, genotoxicity and subchronic toxicity

Yang, Hui; Jia, Xudong

doi:10.1016/j.yrtph.2014.10.014

Cited by 36 publications

(21 citation statements)

References 36 publications

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“…SMC is a naturally occurring organo selenium compound that was identified from a variety of plants, and it was found to be less toxic but with better bioavailability than inorganic or other organic selenium compounds . Recently, the safety of SMC as nutritional supplementation was evaluated in terms of acute toxicity, genotoxicity, and subchronic toxicity, and showed no genotoxicity of SMC . Furthermore, dose studies in rats revealed little if any systemic toxicity of SMC at doses up to 0.9 mg kg −1 BW per day (corresponding to 1.8 mg kg −1 BW per day for mice) after 3‐month oral administration.…”

Section: Resultsmentioning

confidence: 99%

Se‐Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice

Xie

Liu

Zheng

et al. 2018

Molecular Nutrition Food Res

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Section: Resultsmentioning

confidence: 99%

Se‐Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice

Xie

Liu

Zheng

et al. 2018

Molecular Nutrition Food Res

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“…(36) Se-methyl-L-selenocysteine (SeMSC, Se-methylselenocysteine, methyl selenocysteine) can be deaminated to methaneselenol, NH 3 , and pyruvate by selenocysteine lyase (Esaki et al, 1982). SeMSC can be found in many edible plants, including garlic, onions, and broccoli, as well as in dietary supplements (Yang and Jia, 2014). SeMSC was shown to exhibit anticarcinogenic properties (Ip et al, 1991;Medina et al, 2001) and even potentiate the antitumor activity of anticancer drugs (Cao et al, 2014).…”

Section: Pathways Leading To Pyruvate But Not Commencing From Glucosementioning

confidence: 99%

From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity

Chinopoulos

2020

Front. Physiol.

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A metabolic hallmark of many cancers is the increase in glucose consumption coupled to excessive lactate production. Mindful that L-lactate originates only from pyruvate, the question arises as to how can this be sustained in those tissues where pyruvate kinase activity is reduced due to dimerization of PKM2 isoform or inhibited by oxidative/nitrosative stress, posttranslational modifications or mutations, all widely reported findings in the very same cells. Hereby 17 pathways connecting glucose to lactate bypassing pyruvate kinase are reviewed, some of which transit through the mitochondrial matrix. An additional 69 converging pathways leading to pyruvate and lactate, but not commencing from glucose, are also examined. The minor production of pyruvate and lactate by glutaminolysis is scrutinized separately. The present review aims to highlight the ways through which L-lactate can still be produced from pyruvate using carbon atoms originating from glucose or other substrates in cells with kinetically impaired pyruvate kinase and underscore the importance of mitochondria in cancer metabolism irrespective of oxidative phosphorylation.

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“…The Nutritional Prevention of Cancer trial showed selenium-enriched yeast supplements (200 μg/day) had a protective effect on total cancer mortality, and also on total cancer incidence [19]. However, it should be taken into account that an adult should not consume more than 400 μg selenium/day [20,21]. …”

Section: Introductionmentioning

confidence: 99%

The Effect of Zinc and Selenium Supplementation Mode on Their Bioavailability in the Rat Prostate. Should Administration Be Joint or Separate?

et al. 2016

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It is thought that zinc and selenium deficiency may play a significant role in the etiology of prostate cancer. Although joint zinc and selenium supplementation is frequently applied in the prevention of prostate diseases, the bioavailability of these elements in the prostate after co-administration is still unknown. The study examines the effect of subchronic supplementation of zinc gluconate and selenium compounds (sodium selenite or selenomethionine), administered together or separately, on their bioavailability in the prostate, as well as the induction of metallothionein-like proteins (MTs) bound to zinc in the prostate and liver. Zinc concentration in the dorso-lateral lobe of the prostate was significantly elevated already after the first month of supplementation of zinc alone. In the supplementation period, the MTs level increased together with zinc concentration. In contrast, the ventral lobe of the prostate did not demonstrate significantly higher levels of zinc until after three months of supplementation, despite the MTs induction noted after one-month supplementation. Increased selenium levels in the dorsolateral lobe were observed throughout the administration and post-administration periods, regardless of the selenium compound used or whether zinc was co-administered. The results of our studies suggested for the first time that these elements should not be administered jointly in supplementation.

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Safety evaluation of Se-methylselenocysteine as nutritional selenium supplement: Acute toxicity, genotoxicity and subchronic toxicity

Cited by 36 publications

References 36 publications

Se‐Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice

Se‐Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice

From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity

The Effect of Zinc and Selenium Supplementation Mode on Their Bioavailability in the Rat Prostate. Should Administration Be Joint or Separate?

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