Safety evaluation of the food enzyme phytepsin from Cynara cardunculus L.

Lambré, Claude; Baviera, José Manuel Barat; Bolognesi, Claudia; Cocconcelli, Pier Sandro; Crebelli, Riccardo; Gott, David Michael; Grob, Konrad; Lampi, Evgenia; Mengelers, Marcel; Mortensen, Alicja; Rivière, Gilles; Steffensen, Inger‐Lise; Tlustos, Christina; Loveren, Henk Van; Vernis, Laurence; Zorn, Holger; Roos, Yrjö; Andryszkiewicz, Magdalena; Liu, Yi; Chesson, Andrew

doi:10.2903/j.efsa.2022.7681

Cited by 9 publications

(22 citation statements)

References 12 publications

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“…As a probiotic-rich fungus, Aspergillus oryzae enhances gut health by promoting digestion, boosting immunity, and supporting healthy weight management [37], [30]. Moreover, by enhancing nutrient bioavailability and reducing levels of anti-nutritional agents, Aspergillus oryzae improves the nutritional quality of food products [38], [39] [30]. A study reported that rice bran fermented with Aspergillus oryzae exhibited elevated levels of bioactive compounds and antioxidant potential, with both antioxidant qualities and phenolic group counts increasing during the fermentation process [40].…”

Section: The Predominant Utilized Fungi In Indonesian Traditional Foodmentioning

confidence: 99%

Exploring the Utilization of Fungi in Indonesian Traditional Foods: A review

Oktavia,

Zainal,

Djalal

et al. 2024

BIO Web Conf.

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This review focus on examining the significant role of fungi in Indonesian traditional cuisine. It explores how molds, specifically Rhizopus sp. and Aspergillus sp., contribute to the fermentation, preservation, and flavour enhancement of typical Indonesian dishes like tempeh, Oncom, and tape. Beyond their culinary utility, this study delves into the cultural importance of mold-based food traditions, tracing their historical origins and continued prevalence in Indonesian households. Furthermore, the review discusses the nutritional and potential health benefits associated with mold-fermented foods within the Indonesian dietary context. It also addresses the challenges and future prospects of utilizing mold microorganisms in traditional food preparation, highlighting opportunities for ongoing research and innovation. This analysis underscores the enduring and intricate relationship between fungi and Indonesian food, showcasing their influence on the nation's culinary heritage and identity.

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Section: The Predominant Utilized Fungi In Indonesian Traditional Foodmentioning

confidence: 99%

Exploring the Utilization of Fungi in Indonesian Traditional Foods: A review

Oktavia,

Zainal,

Djalal

et al. 2024

BIO Web Conf.

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“…Mice were daily treated orally with 50 μg/kg body weight (bw) per day of BPA or vehicle alone (corn oil) as the control group for 19 days. It was set that dose of BPA since the Environmental Protection Agency (US EPA) had initially established a tolerable daily BPA intake (TDI) of 50 μg/kg bw per day (US EPA, O., 1988), even knowing that EFSA has currently established at 0.2 ng/kg bw per day (EFSA CEP Panel, 2023). Double oral gavage was administered 14 days before dinitrobenzene sulfonic acid (DNBS) injection with BPA and bacteria treatments.…”

Section: Description Of Work Programmementioning

confidence: 99%

Microbiota analysis for risk assessment of xenobiotic exposure and the impact on dysbiosis: identifying potential next‐generation probiotics

López‐Moreno,

Langella,

Martín

et al. 2023

EFS2

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On‐going projects of the team are currently dealing with microbiota, xenobiotics, endocrine‐disrupting chemicals (EDCs), obesity, inflammation and probiotics. The combination of diet, lifestyle and the exposure to dietary xenobiotics categorised into microbiota‐disrupting chemicals (MDCs) could determine obesogenic‐related dysbiosis. This modification of the microbiota diversity impacts on individual health–disease balance, inducing altered phenotypes. Specific, complementary, and combined prevention and treatments are needed to face these altered microbial patterns and the specific misbalances triggered. In this sense, searching for next‐generation probiotics (NGP) by microbiota culturing, and focusing on their demonstrated, extensive scope and well‐defined functions could contribute to counteracting and repairing the effects of obesogens. Therefore, EU‐FORA project contributes to present a perspective through compiling information and key strategies for directed taxa searching and culturing of NGP that could be administered for preventing obesity and endocrine‐related dysbiosis by (i) observing the differential abundance of specific microbiota taxa in obesity‐related patients and analysing their functional roles, (ii) developing microbiota‐directed strategies for culturing these taxa groups, and (iii) design and applying the successful compiled criteria from recent NGP clinical studies. New isolated or cultivable microorganisms from healthy gut microbiota specifically related to xenobiotic obesogens' neutralisation effects might be used as an NGP single strain or in consortia, both presenting functions and the ability to palliate metabolic‐related disorders. Identification of holistic approaches for searching and using potential NGP, key aspects, the bias, gaps and proposals of solutions were also considered in this workplan.

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“…In the latest release of the BPA re-evaluation by the European Food Safety Authority (EFSA) in 2023, the tolerable daily intake of BPA for humans was lowered from 4 μg to 0.2 ng per kilogram of body weight per day (kg/bw/day). People with average or high exposure exceed this threshold, indicating health concerns [ 27 ]. The use of BPA is now limited not just in items designed for infants (EU Commission Regulation 2018/213) [ 28 ] but also in other food contact materials and other products, such as thermal paper, where it should not exceed 0.02% by weight [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Studies on the Binding Mode of Bisphenols to PPARγ

Useini,

Schwerin,

Künze

et al. 2024

Biomolecules

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Bisphenol A (BPA) and bisphenol B (BPB) are widely used in the production of plastics, and their potential adverse health effects, particularly on endocrine disruption and metabolic health, have raised concern. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a pivotal role in metabolic regulation and adipogenesis, making it a target of interest in understanding the development of obesity and associated health impacts. In this study, we employ X-ray crystallography and molecular dynamics (MD) simulations to study the interaction of PPARγ with BPA and BPB. Crystallographic structures reveal the binding of BPA and BPB to the ligand binding domain of PPARγ, next to C285, where binding of partial agonists as well as antagonists and inverse agonists of PPARγ signaling has been previously observed. However, no interaction of BPA and BPB with Y437 in the activation function 2 site is observed, showing that these ligands cannot stabilize the active conformation of helix 12 directly. Furthermore, free energy analyses of the MD simulations revealed that I341 has a large energetic contribution to the BPA and BPB binding modes characterized in this study.

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Safety evaluation of the food enzyme phytepsin from Cynara cardunculus L.

Cited by 9 publications

References 12 publications

Exploring the Utilization of Fungi in Indonesian Traditional Foods: A review

Exploring the Utilization of Fungi in Indonesian Traditional Foods: A review

Microbiota analysis for risk assessment of xenobiotic exposure and the impact on dysbiosis: identifying potential next‐generation probiotics

Structural Studies on the Binding Mode of Bisphenols to PPARγ

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