Safety, immediate and mid-term results of the newer generation of hydrogel coils in the treatment of ruptured aneurysms: a multicenter study

Dabus, Guilherme; Hacein‐Bey, Lotfi; Varjavand, Bahram; Tomalty, R Dana; Han, Patrick; Yerokhin, Vadim; Linfante, Italo; Mocco, J; Oxley, Thomas J.; Spiotta, Alejandro M; Chaudry, M Imran; Turner, Raymond D; Turk, Aquilla S

doi:10.1136/neurintsurg-2016-012780

Cited by 6 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the Clinical and Anatomic Results in the Treatment of Ruptured Intracranial Aneurysms (CLARITY) study comparing BACE with CE in ruptured aneurysms, the authors found no difference in packing density; however, the use of BACE resulted in greater aneurysm occlusion rates (p=0.017) 23. In a study of newer generation hydrogel coils by Dabus et al , there was a trend towards higher rates of complete occlusion in the BACE group but no difference was noted in packing density between the groups 21. Interestingly, in our study, the BACE group demonstrated statistically significant greater rates of immediate occlusion (64% vs 47%; p=0.02) and an important statistical trend towards more complete occlusion on long term angiographic follow-up (64% vs 50%; p=0.09) compared with CE, despite similar packing density and significantly larger mean neck size in the BACE group.…”

Section: Discussionmentioning

confidence: 99%

Angiographic and clinical outcomes of balloon remodeling versus unassisted coil embolization in the ruptured aneurysm cohort of the GEL THE NEC study

Dabus

Brinjikji

Amar

et al. 2017

J NeuroIntervent Surg

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Angiographic and clinical outcomes of balloon remodeling versus unassisted coil embolization in the ruptured aneurysm cohort of the GEL THE NEC study

Dabus

Brinjikji

Amar

et al. 2017

J NeuroIntervent Surg

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the one hand when it comes to postoperative assessments, several previous studies [ 33 , 34 ] have shown that the packing density of aneurysms treated with hydrogel coils was significantly higher, between 36% and 68%, than that of aneurysms treated with bare platinum coils [ 35 ]. In addition, hydrogel coils are more evenly distributed in the aneurysm sac, particularly in the neck of the aneurysm, which may be more helpful in achieving better occlusion rates [ 36 ]. However, these place greater demands on the operator’s surgical skills, and the effect of operator manipulation on coil outcomes is unavoidable and significantly confounding in the literature we included.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Different Bioactive Coils in Intracranial Aneurysm Interventional Treatment, a Systematic Review and Bayesian Network Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

Background: Bioactive coils have been used for nearly 20 years to improve aneurysm treatments. Previous studies are inadequate for comparing the efficacy and safety between different coils. The aim of this study was to investigate the safety and efficacy of different coils by comparing the percentage of people with different modified Raymond scale grades, re-rupture rates, and mortality in patients with intracranial aneurysms embolized with different coils. Method: Randomized controlled trials (RCTs) containing coils for aneurysm interventional treatment were collected from Web of Science, PubMed, and the Cochrane Library up to December 2021. Bayesian network meta-analysis with a randomized or fixed model was performed to compare the efficacy and safety among different bioactive coils and bare platinum coils. Results: We pooled 3362 patients from eight RCTs. No significant differences were found between coils in the proportion of patients with a three-grade classification assessed with the modified Raymond scale immediately after surgery. Hydrogel coils did not show a significant difference in the percentage of patients with a modified Raymond scale grade I postoperatively compared with bare platinum coils (OR, −0.1080; 95% CI, −0.4201–0.2423), but at follow-up, the percentage of patients with modified Raymond scale grade I was significantly higher with hydrogel coils than with bare platinum coils (OR, 0.4957; 95% CI, 0.0060–0.9442). There were no statistical differences between these four coils in terms of aneurysm rupture or re-rupture rate and mortality. Conclusion: Though there was no significant difference in the embolization effect between the several coils in the postoperative period, complete embolization was more likely to be achieved with hydrogel coils compared to bare platinum coils at follow-up. There were no significant differences in safety between the several coil materials.

show abstract

“…Two-dimensional and three-dimensional platinum coils can be applied for aneurysm sac embolism (a) and a typical threedimensional platinum coil (b) configuration from a primary (1°) to secondary (2°) to tertiary (3°) structure (c). IAs, AVMs and AVFs; peripheral vasculature embolization 79% [13] Orbit IAs, AVMs and AVF, peripheral vasculature 56% [18] Bioacti ve coils IAs, AVMs and AVF 77.8% [19] Matrix coil [20] Nexus [15] Submitted to 13 Ultipaq and Helipaq twodimensional filling coils AVF, arteriovenous fistula; AVM, arteriovenous malformation; GDC, Guglielmi Detachable Coil; PGA, polyglycolic acid; PLGA, polylactic-co-glycolic acid.…”

Section: Submitted Tomentioning

confidence: 99%

Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

Zhang

et al. 2018

Advanced Materials

View full text Add to dashboard Cite

Cerebrovascular disease involves various medical disorders that obstruct brain blood vessels or deteriorate cerebral circulation, resulting in ischemic or hemorrhagic stroke. Platinum coils with or without biological modification have become routine embolization devices in the cerebral aneurysm sac to reduce the risk of bleeding. Many intracranial stents, flow diverters and stent retrievers have been invented with uniquely designed structures. To accelerate the translation of these devices into clinical usage, an indepth understanding of the mechanical and material performance of these metal-based devices is critical. However, considering the more distal location and tortuous anatomic characteristics of cerebral arteries, present devices still risk failing to arrive at target lesions. Consequently, more flexible endovascular devices and novel designs are under urgent demand to overcome the deficiencies of existing devices. Herein, we discuss the pros and cons of the current structural designs when these devices are applied to the treatment of diseases ranging broadly from hemorrhages to ischemic strokes, in order to encourage further development of such kind of devices and investigation of their use in the clinic. Moreover, novel biodegradable materials and drug elution techniques, and the design, safety and efficacy of personalized devices for further clinical applications in cerebral vasculature are discussed.

show abstract

Safety, immediate and mid-term results of the newer generation of hydrogel coils in the treatment of ruptured aneurysms: a multicenter study

Abstract: Our data show that the use of the newer-generation hydrogel coils in the treatment of ruptured aneurysms is feasible, safe and effective with high immediate and mid-term occlusion rates and low morbidity.

Cited by 6 publications

References 14 publications

Angiographic and clinical outcomes of balloon remodeling versus unassisted coil embolization in the ruptured aneurysm cohort of the GEL THE NEC study

Angiographic and clinical outcomes of balloon remodeling versus unassisted coil embolization in the ruptured aneurysm cohort of the GEL THE NEC study

Efficacy and Safety of Different Bioactive Coils in Intracranial Aneurysm Interventional Treatment, a Systematic Review and Bayesian Network Meta-Analysis

Endovascular Metal Devices for the Treatment of Cerebrovascular Diseases

Contact Info

Product

Resources

About