Safety issues of peribulbar injection of umbilical cord mesenchymal stem cell (UC-MSC) in patients with retinitis pigmentosa

Mangunsong, C.; Putera, Bayu Winata; Regaïeg, H.; Suwandjaja, M.; Sharina, A.; Sasongko, Muhammad Bayu; Wirohadidjojo, Y.W.

doi:10.1016/j.jcyt.2019.03.500

Cited by 9 publications

(3 citation statements)

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“…Mangunsong et al tested the safety and efficacy of peribulbar infusion of UMSCs in a prospective, multi-center, randomized clinical study (NCT04315025) involving 18 individuals suffering from RP. An improvement in light perception and visus was observed one week after the treatment and no serious side effects was seen during that period [ 186 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases

Adak

Magdalene

Deshmukh

et al. 2021

Stem Cell Rev and Rep

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Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, antiangiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases. Key words Retinal regeneration . cell replacement therapy . exosomes . mitochondrial transfer . anti-inflammatory molecules Abbreviations AMD Age-related macular degeneration ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 ACE2 Angiotensin converting enzyme 2 ADSCs Adipose tissue derived mesenchymal stem cells AMSCs Amniotic membrane derived mesenchymal stem cells APCs Antigen presenting cells ASCs Adipose tissue derived stromal cells BCL-XL B-cell lymphoma-extra-large-protein BCVA Best corrected visual acuity BDNF Brain derived neurotrophic factor BM Bruch's membrane

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Section: Introductionmentioning

confidence: 99%

A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases

Adak

Magdalene

Deshmukh

et al. 2021

Stem Cell Rev and Rep

View full text Add to dashboard Cite

show abstract

“…Mangunsong et al, tested the safety and efficacy of peribulbar infusion of UMSCs in a prospective, multicenter, randomized clinical study (NCT04315025) involving 18 individuals suffering from RP. An improvement in light perception and visus was observed one week after the treatment and no serious side effects was seen during that period [29].…”

Section: Clinical Trials With Mscs For Rpmentioning

confidence: 75%

Untitled

2021

SRDT

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The management of retinitis pigmentosa (RP) and its progression has always been a difficult issue, but promising developments have been shown by the use of mesenchymal stem cells (MSCs). It has thus been evidenced how these cells have significant paracrine and immunomodulatory properties: they secrete trophic factors that stimulate RPE or that are similar to those produced by RPE. In studies using animal models, MSCs have been found to be effective in stopping the progression of retinal degeneration and for rescuing photoreceptors in the dormant phase. Furthermore these cells are hypoimmunogenic and have been shown to suppress chronic inflammation, prevent apoptosis and stimulate progenitor cells in the retina promoting self-repair mechanisms.Previous studies have already evidenced how grafting autologous mesenchymal cells, in a scleral pocket above the choroid, with the limoli retinal restoration technique (LRRT) could exert a beneficial effect on the residual retinal cells in patients with retinitis pigmentosa (RP). This surgical procedure can improve the clinical and rehabilitative prognostic parameters in RP patients even though further researches and studies will be needed to evaluate its efficacy.

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“…However, embryonic stem cells owned ethical concerns, and iPSCs owned tumorigenicity risk 40 . There are also studies using HUCMSCs for treating eye diseases 13 , 41 . Therefore, using HUCMSC-differentiated RPE could be a better option to treat degenerative retinal disease.…”

Section: Discussionmentioning

confidence: 99%

Induction of Human Umbilical Mesenchymal Stem Cell Differentiation Into Retinal Pigment Epithelial Cells Using a Transwell-Based Co-culture System

et al. 2022

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There is an increasing interest in generating retinal pigment epithelial (RPE) cells from stem cells for treating degenerative eye diseases. However, whether human umbilical cord mesenchymal stem cells (HUCMSCs) can differentiate into RPE-like cells in a co-culture system has not been fully understood. In this study, induction of HUCMSC differentiation into RPE-like cells was performed by co-culturing HUCMSCs and a human RPE-like cell line (ARPE19) in a transwell system and then analyzed for biomarkers using quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunofluorescence staining technique. Moreover, the functional characterization of induced cells was carried out by examining their phagocytic and neurotrophic factor–secreting activities. Our results showed that mRNA expressions of RPE-specific markers—MITF, OTX2, RPE65, PEDF, PME17, and CRALBP—and protein markers—RPE65, CRALBP, and ZO-1—were significantly increased in HUCMSC-derived RPE-like cells. Functional characteristic studies showed that these induced cells were capable of engulfing photoreceptor outer segments and secreting brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF), which are typical functions of RPE-like cells. Overall, the study findings indicate that the morphology and proliferation of HUCMSCs can be maintained in a serum-free medium, and differentiation into RPE-like cells can be induced by simply co-culturing HUCMSCs with ARPE19 cells. Thus, the study provides fundamental information regarding the clinical-scale generation of RPE-like cells from HUCMSCs.

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Safety issues of peribulbar injection of umbilical cord mesenchymal stem cell (UC-MSC) in patients with retinitis pigmentosa

Cited by 9 publications

References 0 publications

A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases

A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases

Untitled

Induction of Human Umbilical Mesenchymal Stem Cell Differentiation Into Retinal Pigment Epithelial Cells Using a Transwell-Based Co-culture System

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