This paper examines the influence of safety culture and safety management system on the safety performance of food and beverage (F&B) manufacturing industries in Lagos state, Nigeria. A survey involving 178 questionnaires from safety managers from the F&B manufacturing industries was conducted. The statistical tool SmartPLS was used for analysis due to its ability and flexibility for examining complex models. The results indicated that the safety culture and safety management system were statistically positively related to safety performance. Besides showing the suitability of SmartPLS in statistical analysis, the results also indicated that the firms that intend to achieve their outlined goals regarding safety could greatly benefit from a positive safety management system and safety culture.