Safety of a two-dose investigational hepatitis B vaccine, HBsAg-1018, using a toll-like receptor 9 agonist adjuvant in adults

Abstract

HBsAg-1018 had a similar safety profile to HBsAg-Eng. With improved immunogenicity and fewer doses over a shorter time, HBsAg-1018 has the potential to provide improved seroprotection and a significant public health benefit to adults 18 years of age or older.

The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies

“…This strategy has been shown to be efficient for inactivating MERS-CoV ( 83 ). Sinovac Biotech (Beijing, China) in collaboration with Dynavax (Emeryville, CA, USA) will evaluate the combination of Sinovac's chemically inactivated COVID-19 vaccine candidate ( 86 ) with Dynavax's advanced adjuvant CpG 1018 ( 84 , 85 ). Sinovac is also testing their chemically-inactivated whole SARS-CoV-2 virus particles (PiCoVacc) developed in VERO monkey cells and the adjuvant alum ( 86 ) in phase I/II clinical trials ( Table 2 ).…”

“…Utilizing its patented Trimer-Tag© technology, Clover Biopharmaceuticals has developed a SARS-CoV-2 S-Trimer subunit vaccine candidate SCB-2019 that resembles the native trimeric viral spike ( 182 , 183 ). SCB-2019 is in phase I clinical testing with AS03 ( 94 , 95 ) or CpG 1018 and alum adjuvants [( 84 , 85 ); Table 2 ]. Researchers at the University of Queensland are using the patented molecular clamp technology, which involves synthesizing a protein and subsequently clamping it onto virus-infected cells ( 184 ) as shown previously against flaviviruses ( 96 ).…”

Vaccines for Health Care Personnel

“…This formulation produces better seroprotection than the 3-dose vaccine, significantly shortening the vaccination series without sacrificing safety. [18][19][20][21] Despite higher cost per dose, the convenience and improved immunogenicity of the 2-dose series makes it a cost-effective option for MCOH programs. 22 HBV surface antibody (HBsAb) levels wane over time in a large percentage of people vaccinated over 10 years previously; anamnestic responses to vaccine boosters in this population indicate that once established, immune memory is preserved.…”

Family Counseling for Hepatitis B and Hepatitis C

“…Furthermore, adherence to a three‐dose series of HBV vaccine is limited. However, with the advent of the new HBV vaccine Heplisav, which requires only two doses of vaccine 1 month apart, adherence should improve …”