Safety of an amino-acetonitrile derivative (AAD), monepantel, in weaned lambs following repeated oral administration

Abstract

Repeated oral administration of monepantel at the MRD and three and five times the MRD every 3 weeks for eight treatments was not associated with any treatment-related adverse effects and was systemically very well tolerated in weaned, growing lambs. This study demonstrated that this population of lambs could tolerate accidental overdoses of up to five times the MRD of monepantel or prolonged repetitive administration at recommended doses or overdoses.

Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino‐acetonitrile derivative monepantel in sheep

“…Hennessy and Prichard (1979) suggested that the deaths of cattle administered high volumes of the benzimidazole drug thiabendazole could have occurred after rumen bypass directed lethal concentrations of the drug to the abomasum. Similar results were not experienced either in this study or in ovine target animal safety studies conducted with monepantel, in which recently weaned lambs received eight doses of up to five times the recommended maximum dose at three‐weekly intervals (Malikides and others 2009b), or in adult male and female sheep treated every five days at three times the recommended dose over full reproductive cycles (Malikides and others 2009a, c).…”

“…Similar results were not experienced either in this study or in ovine target animal safety studies conducted with monepantel, in which recently weaned lambs received eight doses of up to five times the recommended maximum dose at three-weekly intervals (Malikides and others 2009b), or in adult male and female sheep treated every five days at three times the recommended dose over full reproductive cycles (Malikides and others 2009a, c). …”